Navigation Links
Mutation improves memory, may lead to memory-enhancing pill

A mind-altering mutation in mice results in an enhanced long-term memory, researchers report in the April 6, 2007 issue of the journal Cell, published by Cell Press. These findings point to a potential target for the development of a drug to treat memory loss, according to the researchers.

The researchers studied a gene that normally increases levels of a natural memory-blocking protein. Animals that carry a defective version of this gene showed improved performance in classical behavioral memory tests, they show. Moreover, animals treated with a small molecule that had the opposite effect—leading ultimately to an increase in the memory-blocker's concentration—showed signs of memory impairment.

"There are very few examples where you can increase memory, especially by deleting genes," said study author Nahum Sonenberg of McGill University in Montreal, Canada. "It's a small, but important part of the big puzzle of how memory works.?

"The next step, which is inevitable, is to look for small molecules that mimic this memory-enhancing effect," he continued.

"If such a pill could be generated, it might provide a new method for treating people with memory-related diseases such as Alzheimer's," said Mauro Costa-Mattioli, a senior postdoctoral fellow in Sonenberg’s laboratory. "While a drug that worked in this way wouldn't cure the disease itself, it might rescue the symptoms of memory loss."

Memories are formed when the repeated activation of brain cells leads to a strengthening of neural connections, or synapses. This process, considered the cellular basis of learning and memory, is known as synaptic plasticity.

Both memory and synaptic plasticity have two components, the researchers explained. One, which is evoked by weak training protocols, yields only transient phenomena—including short-term memory, lasting for minutes to hours, or the beginning stages of longer-term memory storage, lasting for one to three hours.
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
2. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
3. Mutation in blood stem cells provides clues to cancer development
4. Product improves peptide identification for proteomics research
5. Stem cell treatment improves mobility after spinal cord injury
6. Combination therapy improves AIDS-related lymphoma outcome
7. One fish, two fish: New MIT sensor improves fish counts
8. Man-made heart tissue improves cardiac performance
9. Viagra improves high altitude exercise performance up to 45% for some
10. Quitting smoking improves lung function considerably
11. Melatonin improves mood in winter depression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutation improves memory may lead memory enhancing pill

(Date:9/17/2014)... 2014) A rare genetic disorder known as Jacobsen syndrome ... joint investigation by researchers at San Diego State University ... to suggesting better treatment options for people with Jacobsen ... genetic underpinnings of autism., Jacobsen syndrome affects approximately 1 ... Health. It occurs in a person when there is ...
(Date:9/17/2014)... first partial genome sequence of an ancient pig. Extracted ... of the Montsoriu Castle in Girona, the data obtained ... today,s Iberian pig. Researchers also discard the hypothesis that ... The study, published in Heredity , sheds new ... on that of the Iberian breed, considered to be ...
(Date:9/17/2014)... decline, grasses have returned to some once-denuded patches of ... those places seems healthy again, but a new study ... coastal protection remains diminished. , "We,ve got ... back," said ecologist Mark Bertness, professor of biology at ... journal Biological Conservation . "The metric of a ...
Breaking Biology News(10 mins):A link between Jacobsen syndrome and autism 2Iberian pig genome remains unchanged after 5 centuries 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... importance of the world,s natural assets is now firmly on ... showcasing the enormous economic value of forests, freshwater, soils and ... of their loss, was the conclusion of The Economics of ... leader, Pavan Sukhdev. "TEEB has documented not ...
... they have solved an interesting problem: how to get ... complete vegetable protein. What,s more, they,ve joined forces with ... snack they,ve developed into the hands of 1.2 million ... country has decidedly vegetarian tastes, the Indian people just ...
... 19, 2010In response to a study regarding fish oil ... of the Journal of the American Medical Association (JAMA), ... association for the dietary supplement industry, reminds pregnant and ... recommended amounts of docosahexaenoic acid (DHA) throughout pregnancy. This ...
Cached Biology News:TEEB report puts world's natural assets on the global political radar 2TEEB report puts world's natural assets on the global political radar 3TEEB report puts world's natural assets on the global political radar 4TEEB report puts world's natural assets on the global political radar 5TEEB report puts world's natural assets on the global political radar 6Illinois scientists promote soy by currying favor with Indian taste buds 2CRN responds to JAMA fish oil study 2CRN responds to JAMA fish oil study 3
(Date:9/17/2014)... 17, 2014 JH Technologies ... located in Irvine. JH Technologies, a leader in ... recently announced an expanded partnership with Leica Microsystems into ... and image analysis solutions will be featured at the ... The new showroom facility is located within the JH ...
(Date:9/17/2014)... , Sept. 17, 2014 Intarcia ... quantitative data from a study of the cost and ... the 50 th Annual Meeting of the European ... poster session today, Christian Frois , Ph.D., of ... a series of planned Intarcia-sponsored, retrospective studies to characterize ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... molecular diagnostics company pioneering the field of molecular cytology, ... chief operating officer. Mr. Hall joined Veracyte ... company,s commercial entry into endocrinology. Since 2012, he has ... well as managed care and billing functions. As chief ...
(Date:9/17/2014)... Escape Alert, LLC . filed international patents for ... owners if their pet has escaped and enable them to track ... the pet’s body. This is the first implantable microchip with ... around for many years, they are passive until read by scanners, ... pet’s location or alert the owner that the pet has escaped. ...
Breaking Biology Technology:JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3
... , CHICAGO, June 23 Advanced Life Sciences Holdings, ... second non-human primate study involving its novel, once-a-day, oral ... Restanza achieved a 100% survival rate against an inhaled ... the study that received 16 mg/kg once-a-day (the human ...
... , , , Additions to the Human ... over 6,100 antibodies powered by Atlas Antibodies , , ... ) today announced the release of over 2,300 antibody additions ... ( www.sigma.com/prestige ), bringing the total number of ...
... from human patients into fruit flies, we,ve created the ... disease," says Albena Jordanova. "Now we have the opportunity ... as to start looking for substances with therapeutic value." ... between VIB researchers working at the University of Antwerp ...
Cached Biology Technology:Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 2Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 3Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 2Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 3Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 4Fruit fly steps in to fight human disease 2
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
...
...
... Quansys Biosciences Q-Plex Array is a new ... human, mouse, and rat research. The Q-Plex ... ELISA-based test where 4 distinct capture antibodies ... a 96-well plate in a defined array. ...
Biology Products: