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Mutant mouse provides insights into breast cancer

s, however, allow Chaos3 mice to live normal lives but greatly increase the rate of faulty DNA replications and genomic instability.

"It's insidious because there is no warning that one might have this cancer predisposing allele [DNA codings at a given site] because the mice live normally," said Schimenti, who is also director of the Center for Vertebrate Genomics.

The researchers plan to study further the other Mcm genes to see if they, too, play a role in cancers.

The Mcm genes were discovered by Cornell professor of molecular biology Bik Tye, while the pathology of the mouse tumors was performed by Ana Alcaraz, a veterinarian in Cornell's Section of Anatomic Pathology in the Department of Biomedical Sciences.


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Source:Cornell University News Service


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