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Muscle and bone from an ink-jet printer

differentiate into various cell types (e.g., bone- or muscle-like). Immunocytochemical analyses confirmed that the bio-ink patterns successfully directed differentiation of the MDSCs toward a myogenic or an osteogenic lineage in direct registration to patterns.

The proof-of-concept experiment led to the formation of muscle- and bone-like tissues simultaneously in the same culture dish. The long-term promise of this new technology could be the tailoring of tissue-engineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are following up this work by combining the versatile ink-jet system with advanced live cell imaging developed at Carnegie Mellon’s Robotics Institute and Molecular Biosensor and Imaging Center to further understand how stem cells differentiate into bone, muscle, or other cell types.
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Source:American Society for Cell Biology


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