Navigation Links
Muscle and bone from an ink-jet printer

A Pittsburgh-based research team has used an innovative inkjet system to print unique "bio-ink" patterns that directed adult muscle-derived stem cells from mice to differentiate into both muscle cells and bone cells.

This is the first report of a system that can pattern the formation of multiple tissues from a single population of adult stem cells.

Bioengineers from Carnegie Mellon University’s Robotics Institute and the Institute for Complex Engineered Systems teamed with stem cell biologists from the University of Pittsburgh School of Medicine and Children’s Hospital of Pittsburgh to demonstrate the use of ink-jet printing to pattern “bio-inks?combinations of growth factors to control the fate of stem cells. Working with mice, the Pittsburgh biologists have gained considerable experience in using growth factors to control proliferation and differentiation in populations of “muscle-derived stem cells,?or MDSCs. Previous work by University of Pittsburgh researchers has demonstrated the ability of MDSCs to repair muscle in a model for Duchenne Muscular Dystrophy, improve cardiac function following heart failure, and heal large bone defects in the skull. Controlling not only what types of cells differentiate from stem cells, but also gaining spatial control of stem cell differentiation, are important capabilities if researchers are to engineer replacement tissues that might be used in treating disease, trauma, or genetic abnormalities. Spatial patterning of stem cell differentiation through delivery of bio-inks with an ink-jet printer will offer the Pittsburgh researchers a whole new level of complexity and control.

The custom built ink-jet printer, which was developed at Carnegie Mellon, can deposit bio-inks in virtually any design, pattern, or concentration, laying down patterns on fibrin-coated slides placed in culture dishes containing MDSCs. Based on pattern, dose, or factor printed by the ink-jet, the MDSCs could be directed when to differentiate into various cell types (e.g., bone- or muscle-like). Immunocytochemical analyses confirmed that the bio-ink patterns successfully directed differentiation of the MDSCs toward a myogenic or an osteogenic lineage in direct registration to patterns.

The proof-of-concept experiment led to the formation of muscle- and bone-like tissues simultaneously in the same culture dish. The long-term promise of this new technology could be the tailoring of tissue-engineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are following up this work by combining the versatile ink-jet system with advanced live cell imaging developed at Carnegie Mellon’s Robotics Institute and Molecular Biosensor and Imaging Center to further understand how stem cells differentiate into bone, muscle, or other cell types.
'"/>

Source:American Society for Cell Biology


Related biology news :

1. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
2. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
3. Young Blood Revives Aging Muscles, Stanford Researchers Find
4. Muscle repair: Making a good system better, faster; implications for aging, disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... ... an biological outbreak is about to be eliminated, said Lyle Probst, President, CEO ... FireflyDX™ technologies different than other pathogen detection solutions, Probst said, “Sample ...
(Date:9/19/2017)... Sunnyvale, California (PRWEB) , ... September 19, 2017 ... ... cell biology technologies, today announced a partnership with Cytena GmbH to launch the ... technology and real-time image analysis to isolate single cells and provide visual documentation ...
(Date:9/18/2017)... ... 18, 2017 , ... Transportable biomass conversion facilities and the ... is the topic of a September 27 webinar hosted by the ... transportable biomass conversion facilities for producing biochar, briquettes, and torrefied wood, biomass supply ...
(Date:9/18/2017)... (PRWEB) , ... September 18, 2017 , ... ... innovation and business process optimization firm for the life sciences and healthcare industries, ... ServiceMax Maximize 2017 conference. , What: Digital Transformation in Medical Device – The ...
Breaking Biology Technology: