Navigation Links
Movement of chromosome in nucleus visualized

The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around. Researchers from the University of Illinois' Chicago and Urbana-Champaign campuses now offer the first imaging evidence from live cells of ongoing organization and transport within the cell nucleus.

Genes that are active are located mainly in the central region of the nucleus, while inactive genes are at the periphery. But scientists have had no way to track chromosome movement inside the nucleus or to determine whether the location of the chromosomes was the result of random diffusion or if they are moved around by molecular motors.

In a study published in the April 17 issue of Current Biology, UIC and UIUC researchers show that chromosomes in the cell nucleus are capable of directed, long-range movement that depends on actin and myosin, the major molecular motor complex in the cytoplasm.

Developing a system for observing nuclear motion was difficult because chromosome movement is extremely light-sensitive. One exposure to light, and the chromosome would not move, even though the cell appeared undamaged. After extensive experimentation, researchers at UIUC developed a method that allowed them to take pictures without killing the movement.

Using this system, UIUC graduate student Chien-Hui Chuang studied a chromosome that is normally found in an inactive state near the nuclear periphery and moves to the interior of the nucleus when it receives an activating signal.

"The movement following activation was radically different from the rapid, but short-range, diffuse movement previously observed in these nuclei," said Dr. Andrew Belmont, professor of cell and developmental biology at UIUC, principle investigator and co-author of the study. It was clear that this was directed movement that required a motor, Belmont said, because the chromosome was moving in a nearly straight line perpend
'"/>

Source:University of Illinois at Chicago


Page: 1 2 3

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Scientists analyze chromosomes 2 and 4
4. Normal chromosome ends elicit a limited DNA damage response
5. Utah researchers confirm chromosome may harbor autism gene
6. Mouse to man: The story of chromosomes
7. Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers
8. Signature of chromosome instability predicts cancer outcomes
9. Researchers use multiphoton microscopy to watch chromosomes in action
10. Short chromosomes put cancer cells in forced rest
11. Researchers attach genes to minichromosomes in maize
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Movement chromosome nucleus visualized

(Date:5/20/2013)... - A novel vaccine study from South Dakota ... will be unveiled at the American Association of Pharmaceutical ... place Monday, May 20 - Wednesday, May 22 at ... "The main goal of a vaccine is to stimulate ... causes the disease", explained Dr. Hemachand Tummala, assistant professor ...
(Date:5/20/2013)... USA New Geology articles posted ... 2013 cover a wide swath of geoscience subdisciplines, ... geophysics, and paleobotany. Locations studied include Siberia; the ... Alpi Apuane, Italy; Ukraine; Mars; and the Southeastern ... 1. Rubies, jadeite, and plate tectonics;, 2. The ...
(Date:5/19/2013)... strain of electricity-producing bacteria that can grow using hydrogen ... as its sole source of carbon. Researchers at ... the 113th General Meeting of the American Society for ... production solely on hydrogen," says Amit Kumar, a researcher ... part of the Lovley Lab Group at the university. ...
Breaking Biology News(10 mins):Germ-fighting vaccine system makes great strides in delivery 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 3New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 4New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 5New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 6New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 7New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 8New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 9New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 10New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 11
... DURHAM, N.C. Tree growth and fecundity the ... to climate change than previously thought, according to an ... researchers. The study, published April 5 in ... one of several overlooked factors that affect tree reproduction ...
... LANSING, Mich. Monitoring oxygen levels in water has ... more and a professor at Michigan State University ... concept of oxygen sensors isn,t new. The challenge, however, ... temperature, salinity, carbon dioxide, phosphates and biological wastes. Ruby ...
... from Northwestern University and Argonne National Laboratory have ... and its remarkable ability to remove strontium from ... scientists design methods to remove radioactive strontium from ... waste component, is one of the more dangerous ...
Cached Biology News:'Epidemiological' tree study shows impacts of climate change on forests 2Oxygen sensor invention could benefit fisheries to breweries 2Addressing the nuclear waste issue 2Addressing the nuclear waste issue 3
(Date:5/20/2013)... Biomarkers and Clinigene International are set to unveil their ... 2013 AAPS/ National Biotechnology Conference May 20-22 ... Marina , San Diego, CA. ... company representatives at their collaborative seminar, "Biosimilarity, Immunogenicity and ... 1-2 p.m. in the conference,s Spinnaker Room. ...
(Date:5/20/2013)... , May 20, 2013 Cempra, Inc. ... developing differentiated antibiotics to meet critical medical needs ... that it presented data at the American Thoracic ... Philadelphia demonstrating the antibacterial and enhanced ... prior Phase 2 clinical trial in outpatients with ...
(Date:5/20/2013)... 20, 2013 Interventional cardiologist Tony Farah, ... Hospital (AGH) Cardiovascular Institute have helped pioneer many ... disease (CAD) over the past three decades, from ... angioplasty and coronary artery stent implantation. , Today, AGH ... a prominent role in the study of a novel, ...
(Date:5/20/2013)... France (PRWEB) May 20, 2013 On ... this time – in Paris - the beautiful city ... congress chairperson, "Personalized Medicine is revolutionizing the medical world. ... clinical knowledge is the hallmark of this transformation. Much ... care derived from the epidemiologic studies of large cohorts ...
Breaking Biology Technology:Pacific Biomarkers and Clinigene International To Announce Laboratory Solutions for Developers of Biosimilars at 2013 AAPS/ National Biotechnology Conference 2Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP) 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 3Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 4The International Congress on Personalized Medicine - Up Close and Personalized 2013 in Paris 2
... leading MISSION(TM) shRNA ... ... ), a,leading life science company and member of The RNAi Consortium ... ( http://sigma-aldrich.com/rpp ). The RNAi Partnership,Program provides new members with access ...
... Conference Call to Discuss Results to Be Held at ... ViroPharma Incorporated,s,(Nasdaq: VPHM ) third quarter financial results ... 29, 2008 before the open of the U.S.,financial markets., ... live audio webcast at 9:00,a.m. Eastern Time on the ...
... leader will provide commercialization expertise to company, ... Inc., a company,revolutionizing spine care through the development ... William L. Lister as the,newest member of the ... board,s,Compensation Committee and will focus on guiding the ...
Cached Biology Technology:Sigma-Aldrich Welcomes Memorial Sloan-Kettering Cancer Center to the RNAi Partnership Program 2Sigma-Aldrich Welcomes Memorial Sloan-Kettering Cancer Center to the RNAi Partnership Program 3ViroPharma to Release 2008 Third Quarter Financial Results on October 29, 2008 2Axial Biotech Appoints Retired Roche Diagnostics Executive to Board 2
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
Mol wt: average mol wt16,951.27 Da by calculation...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
Biology Products: