Navigation Links
Mouse with designer liver has enhanced glucose tolerance, insulin response

A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes. These results, to be published by Nature Medicine in May, were made available to the scientific community by advance posting online at the journal's website on April 10th.

The liver plays a major role in the uptake of glucose from the bloodstream, its storage, and regulation. Insulin resistance in the liver is a crucial factor in the development of hyperglycemia and hypertriglyceridemia in individuals who suffer type 2-diabetes. Precisely how insulin-initiated signals are modulated in liver cells for glucose uptake and metabolism is unknown.

Gen-Sheng Feng, Ph.D., a Professor in The Burnham Institute's Signal Transduction Program, has focused his efforts on a recently discovered protein called Gab1. Gab1 has a structure that is similar to other proteins in a family known as Insulin Receptor-Signaling, or IRS, proteins. IRS proteins relay signals initiated by insulin receptors and thus play a critical role in insulin regulation inside cells. Biochemical studies on Gab1 in cell cultures suggested that Gab1 is also involved in insulin signaling, but it is not clear how Gab1 acts to control insulin activity in the liver.

To learn how Gab1 functions in the liver, Feng used a highly advanced genetic engineering technology, called tissue-specific gene deletion, to create a mouse in which the Gab1 gene was deleted, or "knocked out", from the liver, and only the liver. Offsprings were termed "LGKO" for liver-Gab1 knockout mice.

Dr. Feng’s laboratory, in collaboration with Drs. Andrea Hevener and Jerrold Olefsky at the University of California, San Diego, conducted a thorough investigation of the glucose metabolism and insulin activity in this newly-cre
'"/>

Source:Burnham Institute


Page: 1 2 3

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
6. Mouse genome much more complex than expected
7. Mouse study: New muscle-building agent beats all previous ones
8. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
9. Mouse to man: The story of chromosomes
10. Mouse mimics chronic leukemia, will aid drug development
11. Mouse study reveals new clues about virulence of 1918 influenza virus

Post Your Comments:
(Date:11/24/2009)...lable in Spanish . , The presence of increa...mmatory substances in the blood, hinders the loss ...arch project of the University of Navarra conducte...School of Pharmacy. , The project, entitled "A n...the control of body weight and inflammation," exam...
(Date:11/23/2009)... community-associated strain of the deadly superbu...ost common antibioticsposes a far greater health t...into hospitals, according to a study in the Decemb...he new threat is easily picked up in fitness cente...ased the overall burden of MRSA within hospitals, ...
(Date:11/23/2009)...3, 2009 - The time of day matters to forest trees ...duced by a research team led by Professor Malcolm ...-principal for research and colleagues in the depa...ge campus. , Capitalizing on their previous wo...search team examined how poplar trees use their 45...
Breaking Biology News(10 mins):It can be predicted the reaction obese patients will have to a diet 2New study finds MRSA on the rise in hospital outpatients 2Time of day matters to thirsty trees, U of T researcher discovers 2Arena Pharmaceuticals to Present at the UBS Global Life Sciences Conference 14150 1Arena Pharmaceuticals to Present at the UBS Global Life Sciences Conference 14150 2Arena Pharmaceuticals to Present at the UBS Global Life Sciences Conference 14150 3Lower Drinking Age Linked to Later Life Problems 57675 1Lower Drinking Age Linked to Later Life Problems 57675 2Lower Drinking Age Linked to Later Life Problems 57675 3Cybernetwork to help K State researchers study tallgrass prairie respond to global warming 9982 1Cybernetwork to help K State researchers study tallgrass prairie respond to global warming 9982 2
...The Stowers Institutes Trainor Lab has demonstrate...velopment of the nervous system, a process that re... neural cells with the cycle of cell division that...s regulating these distinct cellular activities ha...be published in the Feb. 15 issue of Development. ...
...MADISON, WI, January 28, 2008 -- As organic farmin...n the industry are increasingly important. In a re...ientists successfully use nitrogen isotopic discri...rtilizers were used on sweet pepper plants. , Sci...y Desarrollo Agrario y Agrario y Alimentario (IMID...
... Virginia Key, Fla.-- The University of Miamis Ros...nnounced today that it has selected Dennis J. McGi...enstiel Award. McGillicuddy, a senior scientist in...eering at the Woods Hole Oceanographic Institution...study of physical-biological interactions in the o...
Other Biology News:Trainor Lab characterizes gene essential for prenatal development of nervous system 2Is it organic or not? 2Oceanographer Dennis J. McGillicuddy, Jr. receives 34th annual Rosenstiel Award 2
(Date:11/24/2009)...and,November24/PRNewswire-FirstCall/--deCODE,genet...ivednoticefrom,theNasdaqStockMarketthattradinginth...0,2009andaForm25-NSEwillbefiledwiththe,Securitiesa...stock,fromlistingonNasdaq,unlessthecompanyfilesana...panyhasfiledsuchanappeal,which,willstaythesuspensi...
(Date:11/24/2009)...and,November24/PRNewswire-FirstCall/--deCODE,genet...allofits,"firstday"motionsbytheU.S.BankruptcyCourt...CODElastweekfiledavoluntarypetitionfor,reliefunder...nkruptcyCourt. , TheordersissuedbytheBankrupt...essduringtheChapter11proceedings.Inparticular,the,...
(Date:11/24/2009)...4/PRNewswire-Asia/--ShanghaiBiolaxyannouncedthe,Ch...ovedthe,investigationalnewdrugapplication(IND)fori...ormulationtotreatdiabetes.ThisIND,approvalallowsBi... Diabetesisadisordercharacteristicofhighbloodgluco...enresultinseveremicro-and,macro-vasculardiseases,l...
(Date:11/24/2009)...yendpointhasbeenmetforpatientswithadvanced-stage,o....24/PRNewswire-FirstCall/-AEternaZentarisInc.(NASD...euticalcompanyfocusedonendocrinetherapyandoncology...ywithitstargetedcytotoxicpeptideconjugate,AEZS-108...endometrialcancer.Inapersonalizedhealthcareapproac...
Breaking Biology Technology:deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 2deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 3deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3Biolaxy Secures IND Approval for Oral Insulin 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 4
...oy, N.Y. Researchers at Rensselaer Polytechnic In...nexpensive, quick-drying polymer that could lead t...miconductor manufacturing and computer chip packag...nd cost savings for conventional photolithography ...siloxane (PES), should also enable a new generatio...
...E, Jan. 28 Cell Therapeutics, Inc.,(CTI) (Nasdaq ...g today,shareholders approved the proxy proposal a...corporation to increase the number of authorized,s...ase the number of,authorized shares of common stoc...co, Chief Financial Officer at CTI, who chaired th...
...ON, Jan. 28 /PRNewswire-FirstCall/ - Quest PharmaT...d that it has signed a,collaborative research agre...velop a combination therapy for the treatment of l...he Company,s lead oncology product,SL052, with var...that,photodynamic therapy (PDT) can augment the th...
Other Biology Technology:New polymer could improve semiconductor manufacturing, packaging 2Cell Therapeutics, Inc. (CTI) Shareholders Authorize Share Increase at Special Meeting of Shareholders 2Quest PharmaTech and BC Cancer Agency to Develop Immuno Photodynamic Therapies for Lung Cancer 2Quest PharmaTech and BC Cancer Agency to Develop Immuno Photodynamic Therapies for Lung Cancer 3
Mouse Anti-Mouse Qa-2 Monoclonal Antibody, Alexa Fluor 647 Conjugated, Clone 695H1-9-9 from BioLegend
27-mer duplex from B-Bridge International
Propidium Iodide Buffer from BioLegend
Luminex 100 Instrument System from Upstate
Biology Products: