Navigation Links
Mouse to man: The story of chromosomes

The complete sequencing of human chromosome 17 and mouse chromosome 11 offers unique insights into the evolution of the genome of higher mammals, said a Baylor College of Medicine researcher who participated in this effort reported in today's issue of the journal Nature.

The work represents the first time that a mouse chromosome has been completely sequenced and annotated, said Dr. James R. Lupski, vice chair and professor in the BCM department of molecular and human genetics and professor of pediatrics. This presented scientists with the opportunity to examine intensively the similarities and differences in the DNA sequence of human and mouse.

Lupski was brought into the work while he was on sabbatical at the Wellcome Trust Sanger Institute in Cambridge, England, last year. The Sanger Institute and the Broad Institute of MIT and Harvard were the primary institutions involved in the sequencing effort. However, scientists at Sanger dubbed a portion of chromosome 17 the Lupski segment because he has spent so much time dealing with that portion of the genome in his effort to identify gene mutations that result in disease. They sought his expertise on the chromosome.

Chromosome 17 is particularly rich in disease genes such as BRCA1 (the first identified breast cancer gene); NF1 (neurofibromatosis); the gene associated with repairing DNA damage that might otherwise result in cancer (TP53); Smith-Magenis syndrome (SMS), and Charcot-Marie-Tooth type 1A10 (the most common type of inherited nerve disorder [CMT1A]).

The study of this chromosome gives a clearer picture of how genome changes through evolution, Lupski said. For example, breaks in synteny or the maintenance of the order of genes between species coincide with changes in the architecture of the chromosome itself. In some cases, DNA repeats get in the way. In others, there are rearrangements of the genome that occur during the process of cell reproduction.

"As we go up the mammalian line, and particularly in primate, it is obvious that rearrangement in the genome is the predominant force in the evolution of genomes," said Lupski. That is particularly evident in this report that allows carefully comparison of the mouse and human chromosomes.

"Perhaps one way to evolve faster is not by making changes in base pairs (the chemicals that make up DNA), but by changing chunks of genome," said Lupski.

The sequencing of chromosome 17 and mouse chromosome 11 was an international effort involving researchers from around the globe.


'"/>

Source:Baylor College of Medicine


Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Mouse with designer liver has enhanced glucose tolerance, insulin response
6. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
7. Mouse genome much more complex than expected
8. Mouse study: New muscle-building agent beats all previous ones
9. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
10. Mouse mimics chronic leukemia, will aid drug development
11. Mouse study reveals new clues about virulence of 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... ... October 06, 2017 , ... ... its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C ... software to perform Hi-C metagenome deconvolution using their own facilities, supplementing the ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture Network (HTVN) ... their fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited ... competition showcasing early stage digital health and med tech companies. , This day-long ...
(Date:10/5/2017)... ... ... LabRoots , the leading provider of educational and interactive virtual events ... cancer research with a month-long promotion supporting the advancement of breast cancer research with ... promo code PinkRibbon to get 10 percent off their purchase of every the “Cancer ...
(Date:10/5/2017)... ... October 05, 2017 , ... NIH has awarded Circulomics two ... DNA/RNA extraction technology . Nanobind is a novel magnetic disk that contains a ... be used for a wide variety of sample preparation applications. The nanostructured surface ...
Breaking Biology Technology: