Navigation Links
Mouse study reveals new clues about virulence of 1918 influenza virus

The first comprehensive analysis of an animal's immune response to the 1918 influenza virus provides new insights into the killer flu, report federally supported scientists in an article appearing online today in the journal Nature. Key among these insights, they found that the 1918 virus triggers a hyperactive immune response that may contribute to the lethality of the virus. Furthermore, their results suggest that it is the combination of all eight of the 1918 flu virus genes interacting synergistically that accounts for the exceptional virulence of this virus.

Michael G. Katze, Ph.D., of the University of Washington School of Medicine, Seattle, a grantee of the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), led the research team with University of Washington's John Kash, Ph.D. The work with the fully reconstructed 1918 virus was conducted by coauthor Terrence Tumpey, Ph.D., in a biosafety level 3-enhanced laboratory at the U.S. Centers for Disease Control and Prevention in Atlanta.

"Understanding as much as possible about the virus that caused the devastating 1918-1919 influenza pandemic is an urgent imperative as we pursue efforts to prepare for--and possibly thwart--the next flu pandemic," says NIH Director Elias A. Zerhouni, M.D.

"This elegant research gives a detailed picture of the overzealous host reaction to infection by a fully reconstructed 1918 influenza virus," says NIAID Director Anthony S. Fauci, M.D. "The research provides clues as to why the flu of 1918 was so deadly, and may also help us better understand the disease process that occurs when people are infected by emerging avian influenza viruses, such as the H5N1 strain."

Unlike typical seasonal flu, which strikes hardest at the very young, the elderly and those with compromised immune function, the 1918 flu disproportionately killed young people in the prime of life. Modern analyses of 1918 flu v
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Mouse with designer liver has enhanced glucose tolerance, insulin response
6. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
7. Mouse genome much more complex than expected
8. Mouse study: New muscle-building agent beats all previous ones
9. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
10. Mouse to man: The story of chromosomes
11. Mouse mimics chronic leukemia, will aid drug development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse study reveals new clues about virulence influenza virus

(Date:1/22/2015)... , Europe,s most prestigious ... Office to present a video retrospective of the most exciting and ... Christofer Toumazou and Sophie Wilson   A ... Award   Starting on 22 January 2015 on   http://www.epo.org/european-inventor ...
(Date:1/22/2015)... 22, 2015 Infinisource has launched its new NXG series ... The G2 sets a higher standard for collecting attendance and ... solution. With plug-and-play installation, touch screen interface and seamless connection ... robust time collection solution for the small to mid-size employer. ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... the addition of the "The Global Watermarking ... http://photos.prnewswire.com/prnh/20130307/600769 ... global digital media watermarking and fingerprinting markets. Watermarking ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... has entered into a research agreement with Nestl today ... the country. This agreement signed by the two organisations ... including packaged food and beverages, food ingredients, nutrition, food ... biotransformation . 2. The framework research agreement will bring ...
... grow urban centers in an attempt to reduce greenhouse gas ... spacious suburban living, which in many areas, may be cancelling ... Environmental Science & Technology , found that about half ... in the suburbs. Christopher Jones and Daniel M. ...
... were a shrew snuffling around a North American forest, you ... change than if you were a moose grazing nearby. ... University of Colorado Boulder assessment led by Assistant Professor Christy ... on North American mammal responses to human-caused climate change. The ...
Cached Biology News:A*STAR signs agreement with Nestlé to strengthen food & nutrition R&D in Singapore 2Suburban sprawl accounts for 50 percent of US household carbon footprint 2New CU-Boulder study shows differences in mammal responses to climate change 2New CU-Boulder study shows differences in mammal responses to climate change 3
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... GenoSpace , a precision medicine software company that has developed ... of genomic, imaging and other biomedical data in research and ... , CEO of Aspera, an IBM Company, to its board ... "We are pleased to welcome Michelle ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... GMO corn cases filed across the United States, and ... being consolidated in a Kansas federal court for pretrial proceedings. ... Corn Litigation, MDL No. 2591 in the U.S. District Court ... GMO corn multidistrict litigation (MDL) has been handed over to ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... 9 Human Genome Sciences, Inc. (Nasdaq: ... 27th Annual JPMorgan Healthcare Conference will be webcast and ... http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO )A member of Human Genome Sciences, senior ... on Wednesday, January 14, 2009 at 7:30 am Pacific ...
... Enable Stockholders to Determine Fate of Company,s Remaining ... Stockholders Extraordinary Risk/Reward OpportunitySAN FRANCISCO, Jan. 9 ... ("BVF") today announced that it has requested that ... (Nasdaq: AVGN ) call a Special ...
... 9 /PRNewswire-FirstCall/ - Victhom Human Bionics Inc., "Victhom" ... updated corporate Website at www.victhom.com . The ... in the Company,s two operating divisions; Neurobionix, which ... disorders, and Biotronix, which is developing and manufacturing ...
Cached Biology Technology:Biotechnology Value Fund, L.P. Calls Special Meeting of Avigen Stockholders To Remove Incumbent Directors and Elect Slate of Stockholder-Focused Nominees 2Biotechnology Value Fund, L.P. Calls Special Meeting of Avigen Stockholders To Remove Incumbent Directors and Elect Slate of Stockholder-Focused Nominees 3Biotechnology Value Fund, L.P. Calls Special Meeting of Avigen Stockholders To Remove Incumbent Directors and Elect Slate of Stockholder-Focused Nominees 4Biotechnology Value Fund, L.P. Calls Special Meeting of Avigen Stockholders To Remove Incumbent Directors and Elect Slate of Stockholder-Focused Nominees 5Victhom Announces Launch of Enhanced Company Website 2
The PxE Thermal Cycler (PxE) is a licensed 96 well PCR machine, developed to provide all fundamental features for value for money thermal cycling....
For relative and/or absolute quantification with standard accuracy requirements using MS or NMR instruments...
PxE thermal Cycler. 0.5ml block holds 48 0.5 ml tubes or 96 0.3 ml tubes. Adjustable height heated lid. Outstanding uniformity. Advanced control algorithms for reduced reaction times. User frien...
For testing the AQUA technique on your MS instruments....
Biology Products: