Navigation Links
Mouse mimics chronic leukemia, will aid drug development

enetics and director of human cancer genetics at the OSUCCC-James.

Croce and his laboratory developed the mouse strain in 2002. The researchers engineered the animal so that key immune cells called B lymphocytes, or B cells, overproduce a protein called TCL-1. This overproduction causes the CLL-like disease, which develops about a year after birth, though how it does so is still unknown.

Human CLL is also a cancer of B cells, but it involves many chromosome and gene changes. Byrd and his laboratory are currently investigating whether human CLL cells also have high TCL-1 levels.

In this study, Byrd and his research team followed the development of the CLL-like disease in the mouse strain and found that the malignant mouse cells show many of the molecular characteristics of human CLL cells, such as expression of proteins called Bcl-2, Akt and normal p53.

The study also shows that the mouse disease mirrors CLL patients in its response to the drug fludarabine, including the development of resistance.

"This suggests that we can use this model to study the molecular changes that lead to fludarabine resistance and perhaps learn how to circumvent it," says first author Amy J. Johnson, research scientist in Byrd's laboratory.
'"/>

Source:Ohio State University


Page: 1 2

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Mouse with designer liver has enhanced glucose tolerance, insulin response
6. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
7. Mouse genome much more complex than expected
8. Mouse study: New muscle-building agent beats all previous ones
9. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
10. Mouse to man: The story of chromosomes
11. Mouse study reveals new clues about virulence of 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse mimics chronic leukemia will aid drug development

(Date:3/20/2015)... and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the ... Report" report to their offering. This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided ...
(Date:3/17/2015)... 2015 Emotient, the leader in facial ... general availability of Emotient Analytics , the ... of facial expressions. The system analyzes videos of ... and services. It delivers audience response metrics - ... as derived from facial evidence of emotional states. ...
(Date:3/12/2015)... March 12, 2015 The mascots of the ... Hospital, part of Wake Forest Baptist Medical Center. They ... the 2015 ACC Men,s Basketball Tournament. Young patients enjoyed ... and getting their autographs. Brenner Children,s Hospital ... is the only children,s hospital in northwest ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... to display the earliest signs of Parkinson,s disease using the ... the disease. The mouse model, which expresses the same ... of constipation and other gastrointestinal problems that are a common ... result, researchers say, these animals could serve as a means ...
... Bethesda, MarylandThe American Association of Anatomist,s (AAA) presented its ... Meeting in Anaheim. This year,s honors went to: ... Dept. of Cell and Developmental Biology at SUNY Upstate ... the 2010 Henry Gray/ Lippincott Williams & Wilkins Scientific ...
... in Spanish . ANN ARBOR, Mich. ... treat breast cancer by targeting cancer stem cells -- the ... according to a new study from researchers at the University ... a component of broccoli and broccoli sprouts, in both mice ...
Cached Biology News:UCSF transgenic mouse mimics Parkinson's earliest symptoms 2UCSF transgenic mouse mimics Parkinson's earliest symptoms 3Broccoli component limits breast cancer stem cells, U-M study finds 2
(Date:3/26/2015)... PAREXEL International Corporation (Nasdaq: ... organization , announced today that the Company ... all of the business assets of privately-owned Quantum ... specialized pharmacovigilance services, based in Chandigarh, India.  ... monitoring, and prevention of adverse effects with ...
(Date:3/26/2015)... "In America," the popular news television program that ... hosted by legendary film actor James Earl Jones, has announced ... upcoming segment. , Botany is commonly described as the ... quite a bit more complicated than that. Scientists and other ... organisms, from the smallest bacteria known to man to the ...
(Date:3/26/2015)... March 26, 2015 WriteResult, a premier ... researchers from Yale University’s School of Public Health and ... participants during a 4 month-long project. The goal of ... low income families with free access to fresh produce ... diet-related health concerns like high blood pressure, diabetes and ...
(Date:3/25/2015)... Balaton, MN (PRWEB) March 26, 2015 ... an upcoming episode of American Farmer, airing for the ... RFD-TV. The segment of American Farmer will explore the ... Agnition provides crop producers with a patented Microbial Catalyst™ ... farms and greater yields. The segment will air again ...
Breaking Biology Technology:PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
... a global chemistry-driven contract research organization, announced today that ... one of the leading CRO companies conducting high quality ... Prudentas will continue to operate separately under the business ... to the acquisition ChemDiv had worked with Prudentas, who ...
... Science, Scale and Talent Required to Meet Growing Demand , ... ... enable farmers to produce enough grain to meet the growing demand ... regulators and policymakers from around the globe take a more holistic ...
... Accreditation StandardsWASHINGTON, April 16 URAC ... announced today that Director of Pharmacy Programs Janice Anderson, ... 21st Annual Academy of Managed Care Pharmacy (AMCP) ... health care professionals dedicated solely to the issues of ...
Cached Biology Technology:ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 2ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 2DuPont Leader: Agriculture is Up to Global Productivity Challenge 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 4URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 2URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 3
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
... The Helios gene gun system, 220-240 V, ... biomaterials into cells. This handheld device employs ... RNA-, and other biomaterial-coated gold microcarriers from ... cartridge directly into target cells. This system ...
Mouse monoclonal antibody raised against a partial recombinant NEK2. NCBI Entrez Gene ID = NEK2...
... DNA Technologies also offers a DNA sequencing ... templates including plasmids, PCR products, BACs, etc. ... templates such as purified plasmids or purified ... handling robotics optimized for automated reaction setup ...
Biology Products: