Navigation Links
Mouse mimics chronic leukemia, will aid drug development

A study by cancer researchers here reveals that a new strain of mice offers the first real animal model for an incurable form of chronic leukemia and should greatly aid the development of new drugs for the disease.

The mouse, called the TCL-1 transgenic mouse, develops a malignancy that closely mimics chronic lymphocytic leukemia (CLL). The lack of an animal model has greatly hampered the development of new treatments for CLL as well as research into its causes and the changes that drive drug resistance.

"This mouse strain shares many of the molecular and genetic features of human CLL, responds to drugs typically used to treat the disease and develops drug resistance that renders treatment ineffective, as often happens in CLL patients," says principal investigator John C. Byrd, professor of internal medicine.

Byrd is a specialist in CLL at the Ohio State University Comprehensive Cancer Center ?Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James).

"The strain should be extremely valuable for the development and testing of both conventional drugs and those aimed at molecular targets for CLL."

The findings are published in the Aug. 15 issue of the journal Blood, which includes a commentary about the significance of the research.

An estimated 10,000 Americans will develop CLL in 2006, and about 4,600 will die of the disease. The malignancy usually strikes people aged 50 or older and causes the proliferation of white blood cells called lymphocytes. Other effects include severe anemia and a high risk of viral, bacterial and fungal infections. Average survival after diagnosis is eight to 12 years. The standard treatment for CLL is the drug fludarabine, but the disease often becomes resistant to the drug.

This TCL-1 mouse strain was originally developed by OSU cancer researcher Carlo M. Croce, professor and chair, department of molecular virology, immunology and medical g enetics and director of human cancer genetics at the OSUCCC-James.

Croce and his laboratory developed the mouse strain in 2002. The researchers engineered the animal so that key immune cells called B lymphocytes, or B cells, overproduce a protein called TCL-1. This overproduction causes the CLL-like disease, which develops about a year after birth, though how it does so is still unknown.

Human CLL is also a cancer of B cells, but it involves many chromosome and gene changes. Byrd and his laboratory are currently investigating whether human CLL cells also have high TCL-1 levels.

In this study, Byrd and his research team followed the development of the CLL-like disease in the mouse strain and found that the malignant mouse cells show many of the molecular characteristics of human CLL cells, such as expression of proteins called Bcl-2, Akt and normal p53.

The study also shows that the mouse disease mirrors CLL patients in its response to the drug fludarabine, including the development of resistance.

"This suggests that we can use this model to study the molecular changes that lead to fludarabine resistance and perhaps learn how to circumvent it," says first author Amy J. Johnson, research scientist in Byrd's laboratory.
'"/>

Source:Ohio State University


Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse gene shows new mechanism behind cardiac infarction in man
5. Mouse with designer liver has enhanced glucose tolerance, insulin response
6. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
7. Mouse genome much more complex than expected
8. Mouse study: New muscle-building agent beats all previous ones
9. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
10. Mouse to man: The story of chromosomes
11. Mouse study reveals new clues about virulence of 1918 influenza virus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
(Date:2/13/2017)... SAN FRANCISCO , Feb. 13, 2017 /PRNewswire/ ... a centralized platform that is designed to enhance ... the latest release in the RSA Fraud & ... to enable organizations to leverage additional insights from ... anti-fraud tools to better protect their customers from ...
(Date:2/9/2017)... The biomass boiler market report by Transparency Market Research ... in terms of revenue (US$ Mn) based on the ... boilers has been segmented on the basis of feedstock ... based on feedstock type, has been segmented into woody ... urban residues, and others. On the basis of product ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... up human tissue regeneration from small lab samples to full-size tissues, bones, even ... to establish a vascular system that delivers blood deep into the developing tissue. ...
(Date:3/22/2017)... , March 22, 2017 Good Start Genetics, ... has eclipsed the 130 million covered lives mark through ... of Texas . With newly signed ... continues to enjoy strong payor acceptance based on the ... programs and genetic counseling, its industry-leading customer care and ...
(Date:3/22/2017)... 2017 The global chronic kidney ... report by Transparency Market Research (TMR). The top four ... AbbVie Inc., accounted for a share of only 41.4% ... this market are focusing aggressively on mergers, acquisitions, and ... likely to lead to market consolidation in the next ...
(Date:3/22/2017)... Mass. , March 22, 2017   Boston ... next-generation cancer therapeutics designed to target cancer stemness pathways, ... Patricia S. Andrews as Chief Executive Officer, effective ... succeed Chiang J. Li , M.D., FACP, who ... ten years ago. Under his leadership, Boston Biomedical has ...
Breaking Biology Technology: