Navigation Links
Mouse gene shows new mechanism behind cardiac infarction in man

A gene that, in different variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding human gene has been shown to play a role in the development of myocardial infarction.

The results of the study is published this week on Nature Genetics Online.

Researchers at Karolinska Institutet, in collaboration with the Jackson Laboratory in the USA, AstraZeneca and a Japanese research group, have scrutinised an area on chromosome 1 that is of demonstrable importance to the development of arteriosclerosis. The TNFSF4 gene was identified as the one responsible, as mice with mutations in this gene displayed a lower degree of atherosclerosis, while mice with more active variants of the gene displayed the opposite.

Studies of two patient groups revealed that a certain variant of the human homologue of the gene was more common in people who had a history of cardiac infarction than those without.

“This is an example of how an unbiased genetic strategy based on a mice model can teach us more about common human diseases,?says researcher Jacob Lagercrantz of the Gustav V research institute, Karolinska Institutet.

The gene codes for a protein called OX40L, which is involved in the activation of immunological T cells. These cells, in turn, play an important role in the pathogenesis of atherosclerosis and of a number of chronic inflammatory diseases. The new finding will spur further research into the relationship between the protein and cardiac infarction. Hopefully it will offer a new therapeutic technique for the treatment of atherosclerosis and thus reduce the risk of cardiac infarction.


'"/>

Source:News-Medical


Page: 1

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Mouse brain tumors mimic those in human genetic disorder
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Mouse with designer liver has enhanced glucose tolerance, insulin response
5. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
6. Mouse genome much more complex than expected
7. Mouse study: New muscle-building agent beats all previous ones
8. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
9. Mouse to man: The story of chromosomes
10. Mouse mimics chronic leukemia, will aid drug development
11. Mouse study reveals new clues about virulence of 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse gene shows new mechanism behind cardiac infarction man

(Date:3/24/2015)... GARDENS, Fla. , March 24, 2015 /PRNewswire/ ... identity management solutions, today announced that its U.are.U ... clothing accessory retailer Goorin Bros . to ... Crossmatch biometrics-based solution secures access to the POS ... the increased risk of data breaches. ...
(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... campaign on CNBC television starting March 30 th . ... airing in New York markets. ... "We are excited about our new ad campaign following the ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... used to process color is separate from that used ... researchers at New York Universitys Center for Developmental Genetics ... Germanys University of Wrzburg. The findings, which appear in ... Academy of Sciences, run counter to previous scholarship that ...
... While rabbits continue to ravage Australias native landscapes, rabbit fish ... from destruction. The reason, say scientists, is the same ... efficient herbivores, capable of stripping an area of vegetation. However, ... that is the problem and the rabbit fish, the ...
... of passerine birds is a conspicuous and exaggerated display ... competition or mate attraction. At the level of the ... Paola Laiolo and colleagues at the Spanish ... the Duponts lark in north-eastern Spain and found an ...
Cached Biology News:Scientists find color vision system independent of motion detection 2Rabbits to the rescue of the reef 2Rabbits to the rescue of the reef 3
(Date:3/26/2015)... -- Neogen Corporation (NASDAQ: NEOG ) announced today ... fiscal 2015, which ended Feb. 28, increased 13% to ... per share in the current quarter were $0.20, compared ... increased 17% over prior year to $24,142,000, or $0.65 ... for the same period a year ago. ...
(Date:3/26/2015)... 2015 "In America," the popular news television ... that is hosted by legendary film actor James Earl Jones, ... in an upcoming segment. , Botany is commonly described ... is actually quite a bit more complicated than that. Scientists ... of living organisms, from the smallest bacteria known to man ...
(Date:3/25/2015)... of the most attractive in the emerging European region, ... economy and increasing government investment in healthcare, according to ... is set to grow at twice the pace of ... annually reaching an approximate market value of $43-60 billion ... Green Cross provides total healthcare solutions that address the ...
(Date:3/25/2015)... 25, 2015 Optimal Research, LLC has been ... (ViE) Award "Best Clinical Site or Trial Network". ... has been selected as a nominee in this ViE ... "Highly Recommended" distinction in 2014. The ViE awards were ... accomplishments, and positive contributions of companies and individuals in ...
Breaking Biology Technology:Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2
... Economic Development on the ... BURLINGTON, Mass., Sept. 10 Hyaluron Contract,Manufacturing (HCM), ... the pharmaceutical and biotechnology industries, announced,today that it has ... Economic Impact Award. HCM is one of five companies ...
... Group, Inc. (OTC Bulletin Board: MBTG) announced that ... equity securities.,These securities have not been registered under ... offered or sold in the United States absent ... the registration,requirements. Millennium, through its wholly owned subsidiary, ...
... US Team with Addition of Jonathan Monteleone and ... ... Sept. 10 Pharsight,Corporation (OTC Bulletin Board: PHST), a leading ... today,announced that it has hired Jonathan Monteleone, M.S., and Herbert,Struemper, ...
Cached Biology Technology:Hyaluron Contract Manufacturing Named a 2007 Economic Impact Award Finalist 2Millennium Biotechnologies Group, Inc. (MBTG.OB) Announces Completion of $2,277,000 Equity Financing 2Pharsight Expands Strategic Consulting Services Team 2
Anti-Indolamine (Indoleamine) 2,3-dioxygenase Immunogen: Recombinant human IDO. Available Date: 38454...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
...
Biology Products: