Navigation Links
Mouse brain tumors mimic those in human genetic disorder

A recently developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1 (NF1) successfully mimics the human condition and provides unique insight into tumor development, diagnosis and treatment, according to researchers at Washington University School of Medicine in St. Louis. After validating their animal model, the team made two important discoveries: New blood vessels and immune system cells may be essential to the initial formation of tumors and therefore may be promising drug targets; and brain images often used to determine the need for treatment may not actually be diagnostically informative.

"These mice develop brain tumors with many of the same features as those seen in children with NF1, and studying those tumors has helped us understand the cellular events involved in NF1 brain tumor development," says principal investigator David H. Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology. The study appears online and will be published in the January 2005 issue of the journal Annals of Neurology. NF1 is one of the most common neurological disorders caused by a single gene mutation. The disorder can lead to a variety of complications including brain cancer. To supplement their clinical research, Gutmann's team developed a mouse model in which the animals, like humans with the disease, have one abnormal copy of the gene for NF1 in every cell in their body, while specific support cells in the brain called astrocytes have two abnormal copies of this same gene. Their latest paper shows that brain tumor formation in these mice has several of the same distinguishing clinical characteristics as tumor development in children with NF1. First, the mice developed tumors along the optic nerve and optic chiasm, which transmit visual information from the eye to the brain. This type of tumor, called an optic pathway glioma, is the most common tumor in children with NF1. Second, the time course of tumor development was
'"/>

Source:Washington University of St Louis


Page: 1 2 3

Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
3. Mouse gene shows new mechanism behind cardiac infarction in man
4. Mouse with designer liver has enhanced glucose tolerance, insulin response
5. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
6. Mouse genome much more complex than expected
7. Mouse study: New muscle-building agent beats all previous ones
8. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
9. Mouse to man: The story of chromosomes
10. Mouse mimics chronic leukemia, will aid drug development
11. Mouse study reveals new clues about virulence of 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse brain tumors mimic those human genetic disorder

(Date:7/9/2014)... from China challenges the commonly held belief that birds ... to fly. The birdlike fossil is actually not a ... of a tiny tree-climbing animal that could glide, say ... Blanding, Utah, and Alan Feduccia of the University of ... of Ornithology . , The fossil of the ...
(Date:7/9/2014)... measurement results accrue. To completely and systematically archive ... In fact, researchers in the life sciences spend ... to an online survey of 70 people working ... for Applied Information Technology FIT in Sankt Augustin. ... no centralized or structured approach to data collection ...
(Date:7/9/2014)... with high levels of vitamin D in their blood are ... , Patients with the highest levels of vitamin D have ... lowest levels, the findings reveal. , The study is the ... bowel cancer patients after their diagnosis which includes that ... sources with their long term survival prospects. , ...
Breaking Biology News(10 mins):Researchers declassify dinosaurs as being the great-great-grandparents of birds 2Managing the data jungle 2Managing the data jungle 3
... to stop the spread of drug resistance in typhoid fever, ... published in the journal eLife . The ... bacteria can out-compete drug sensitive strains when grown in the ... is transmitted by consuming food or drink that is contaminated ...
... 9, 2013 /PRNewswire-iReach/ -- With the holiday season comes the ... American will put on up to five pounds in just ... CDC (Center for Disease Control) more than 65% of Americans ... obese. (Photo: http://photos.prnewswire.com/prnh/20131209/MN29878 ) ...
... inhibitors (SSRIs) are the most commonly prescribed antidepressants, but ... often try several different SSRI medications, each with a ... is effective. It takes three to four weeks to ... and their families continue to suffer. Now researchers ...
Cached Biology News:Antibiotic-resistant typhoid likely to spread despite drug control program 2HCG Injections and B12 shots now in stock at US Vitamin Injections Site 2A personal antidepressant for every genome 2A personal antidepressant for every genome 3
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, 2014 ... Country Club, 1360 Almshouse Road, Warrington, Pa. , ... solely dedicated to finding a cure for hepatitis B and ... host its annual Crystal Ball on Friday, April 11 at ...
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014  RXi ... on discovering, developing and commercializing innovative therapies addressing ... announced that it received the Notice of Allowance ... on its unique self-delivering RNAi compounds (sd-rxRNA®), for ...
(Date:1/14/2014)... During the 1600’s through the 1800’s doctors contributed unknowingly ... this time period, doctors did not know that they needed ... death of vulnerable patients. In the same way, medical interns ... unwittingly transmitting herpes viruses to their patients. The CBCD explains. ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... A key lawmaker who often disagrees with Governor Jim ... saw nothing inappropriate about the governor's use of an executive ... cell companies. , ,Meanwhile, the executive order, signed Tuesday at ... the director of Pro Life Wisconsin. , ,Ted Kanavas, R-Brookfield, ...
... GE Healthcare has received federal approval for yet ... for the estimated 20% of Americans that are considered obese. ... the Food and Drug Administration for its new wide bore ... The system is designed to meet growing demand for better ...
... Is your brand valuation worth a billion dollars today? Maybe yes ... At the end of the day, all the work you have ... and services in your marketplace adds up in an abstract space ... equity can be measured as a real, soft asset. It can ...
Cached Biology Technology:Republican sees nothing wrong with Doyle's use of executive order 2FDA okays new GE tomography system 2Is your brand worth billions? 2Is your brand worth billions? 3
MAb to Desmoplakin I & II Desmoplakin I & II...
... in conjuction with Annexin V-FITC to distinguish ... of apoptosis (Annexin V positive, PI negative) ... of apoptosis or already dead (Annexin V-FITC ... the orange range of the spectrum using ...
The BD CBA Human Apoptosis Kit can be used to quantitatively measure,cleaved PARP, Bcl-2, and active Caspase-3 protein levels in a single sample. The,Kit performance has been optimized for analysis o...
... Sf9 Insect Cells are derived from the Spodoptera ... optimal growth, use in transfections, plaque assays, virus ... in a protocol that optimizes recovery of viable ... in serum-free BacVector Insect Cell Medium and can ...
Biology Products: