Navigation Links
Morphine for Chest Pain Increases Death Risk

While patients hospitalized for a heart attack have long been treated with morphine to relieve chest pain, an analysis by researchers from the Duke Clinical Research Institute has shown that these patients have almost a 50 percent higher risk of dying.

The researchers call for a randomized clinical trial to confirm their analysis. Meanwhile, they advise cardiologists to begin treatment with sufficient doses of nitroglycerin to relieve pain before resorting to morphine.

In their analysis of the clinical data and outcomes of more than 57,000 high-risk heart attack patients -- 29.8 percent of whom received morphine within the first 24 hours of hospitalization -- the researchers found that those who received morphine had a 6.8 percent death rate, compared to 3.8 percent for those receiving nitroglycerin. The increase in mortality persisted even after adjustment for the patients' baseline clinical risk.

The results of the Duke were published as a fast-track article in the American Heart Journal.

"The results of this analysis raise serious concerns about the safety of the routine use of morphine in this group of heart patients," said Duke cardiologist Trip Meine, M.D., the study's lead author. "Since randomized clinical trials evaluating the safety or effectiveness of morphine for these patients have not been conducted, official guidelines for its use are based solely on expert conjecture. Given the adverse outcomes associated with morphine use found in our analysis, a randomized clinical trial is in order."

Morphine was first used to relieve the chest pain associated with heart attacks in 1912 and has been used regularly ever since. Nitroglycerin has been used for more than 130 years for the relief of chest pain, also known as unstable angina. It works by relaxing blood vessels and allowing blood flow to increase.

"Nitroglycerin has a physiological effect that may, at least temporarily, influence the underlying ischemia," Me
'"/>

Source:DukeHealth


Page: 1 2 3

Related biology news :

1. Morphine makes lasting -- and surprising -- change in the brain
2. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
3. New Estimates For The Causes Of Child Deaths Worldwide
4. Measles Deaths Worldwide Drop By Nearly 40% Over Five Years
5. Are U.S. Flu Death Figures More PR Than Science?
6. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
7. Male Combat Veterans Rank High In Heart Disease Risk
8. FDA: Highly Unlikely Green Tea Lowers Cancer Risk
Post Your Comments:
(Date:7/24/2008)... , NEW YORK, July 24, 2008 In the life of a cel...he cell is fated to pause and repair itself, commi... to cancer. In a new study, published in the July ...dical Center have identified a way that cells resp...roteins for disposal. The finding points to a new ...
(Date:7/24/2008)..., Irvine, Calif. UC Irvine researchers have fou... own body clock and metabolism. The discovery rev...es, obesity and other related diseases. , Paolo ...f Pharmacology, and his colleagues have identified...ates the body,s circadian rhythms, works in balanc...
(Date:7/24/2008)... GAINESVILLE, Fla. If worms could talk, they mig...ggle," complete with that telltale come slither lo...own as pheromones, a complex chemical code researc...hed Wednesday (July 23) in the journal Nature . ...nell University, the California Institute of Techn...
(Date:7/24/2008)..., AMES and IOWA CITY, Iowa The University of Io...ources to significantly enhance both institutions,...utions have each purchased a massively parallel DN...DNA sequences at the rate of millions to billions ...ith unique advantages will be available on a fee-...
Breaking Biology News(10 mins):A new cellular pathway linked to cancer is identified by NYU researchers 2Circadian rhythm-metabolism link discovered 2Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3UI and ISU establish shared DNA sequencing instrumentation 2UI and ISU establish shared DNA sequencing instrumentation 3How mother of thousands makes plantlets 647 1National Breast Cancer Awareness Month 2651 1National Breast Cancer Awareness Month 2651 2MannKind Corporation Raises 24250 Million in Self Managed Registered Direct Offerings of Common Stock 1000 1MannKind Corporation Raises 24250 Million in Self Managed Registered Direct Offerings of Common Stock 1000 2MannKind Corporation Raises 24250 Million in Self Managed Registered Direct Offerings of Common Stock 1000 3Toy Blocks Might Boost Toddlers Language Skills 2644 1Toy Blocks Might Boost Toddlers Language Skills 2644 2
...Tissue engineering has emerged as a promising alte...organs and tissues, circumventing the complication...engineers attempt to repair or regenerate damaged ... can sustain functionality during regeneration and...aditional tissue-engineering paradigm combines iso...
...Autoimmune diseases such as type 1 diabetes, lupus...stem fails to regulate itself. But researchers hav...ns responsible for such failures occur. Now, a tea...he Dana-Farber Cancer Institute have identified a ...e disease, findings that may help scientists devel...
...Planning and worrying about the future has always ... now at least one species of bird has also been fo...the intriguing possibility that, like humans, bird...shed today (22 February) in the journal Nature sho...ture food shortages by caching food. The birds are...
...A new hereditary breast cancer gene has been disco... Cancer Research and the Plastic Surgery Clinic at...s found that women with a certain hereditary defor...k of contracting breast cancer than expected. , S...een searching for new hereditary breast cancer gen...
Other Biology News:Cracking open the black box of autoimmune disease 2Birds found to plan for the future 2New hereditary breast cancer gene discovered 2
(Date:7/25/2008)...e-FirstCall/ -- China Medical,Technologies, Inc. (...ased,medical device company that develops, manufac...ducts and high intensity focused ultrasound tumor,...version rate for the,Company,s US$150 million outs... due November 2011 (the ,Convertible Notes,)., ...
(Date:7/24/2008)...wswire-FirstCall/ -- Coherent, Inc.,(Nasdaq: COH...financial,results after the market close and host ... 2008 results scheduled for July 30, 2008 at 4:30 ...e Internet and can be accessed,at either http://w...s.com .,For those who are not available to listen ...
(Date:7/24/2008)...ire-FirstCall/ -- InterMune, Inc.,(Nasdaq: ITMN )...er 2008,financial results and provide a business u...ern time. A live conference call and webcast will ...hat same day., To access the live teleconference,...tional), conference ID# 57393097. To access the,we...
(Date:7/24/2008)...an to Help Spearhead Growth, PITTSBURGH, July 24 ...http://www.hmsinc.com ), pioneering health informa...l has been appointed vice president, sales., Dock...les, sales,management and product distribution for...and pharmaceutical companies., "Karen has an impr...
Breaking Biology Technology:China Medical Technologies Adjusts Conversion Rate of Convertible Notes 2InterMune to Release Second Quarter 2008 Financial Results and Provide Business Update on July 31 2Health Monitoring Systems Appoints Karen S. Dockrell As VP, Sales 2
... - The recent decision by a young researcher to l...osed some of the financial consequences of the sam...n associate engineering physics professor and nano...nts since coming to Madison in 2000. At the end of... with him to the University of Pennsylvania , whe...
...ders of this bog are a tough crowd. I got pummeled...ts about the Cingular 8125 mobile device that I j...to engender more good feelings. , ,Angus H., whose...ition clear, took me to task for comments that imp..., talk on my mobile phone while driving. Angus is ...
...ll the hype, all the emotional arguments, and all ...are you really getting? , ,In the great race for g... broadband connectivity and broadband connectivity...is the need for speed. Thats all the consumer need...know. , , AT&T,s Project Lightspeed offers data...
... - The WiCell Research Institute , the non-profi...g all 21 federally funded stem cell lines in the U... director. , ,Donley, who led litigation and paten...sel, is now implementing its growth strategy and s...ercialize stem cell technology is igniting across ...
Other Biology Technology:Departure of nanotech researcher stings UW 2Departure of nanotech researcher stings UW 3Am I spoiled if I expect well-designed mobile devices? 2Am I spoiled if I expect well-designed mobile devices? 3Broadband blues: Don't fall for Lightspeed hype 2Broadband blues: Don't fall for Lightspeed hype 3Broadband blues: Don't fall for Lightspeed hype 4Broadband blues: Don't fall for Lightspeed hype 5Donley has growth plans for stem cell bank 2Donley has growth plans for stem cell bank 3
...rvices are uniquely positioned to help you prevail...ns experts employ sophisticated, proprietary techn...s that match your needs: Structure/Function Studie...tabolic labelling), Protein-protein interactions, ...
albumin from bovine serum (BSA), fluorescein conjugate
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details.
The Varian Cary 50 Microplate Reader accessory for UV-Vis reduces your cost per analysis by extending the versatility and throughput of the award-winning Cary 50 instruments. Use it to analyze up to
Biology Products: