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Moonlighting enzyme linked to neurodegenerative disease

or decrease the levels of frataxin in patients," she says.

Identifying and confirming the role of this moonlighting enzyme could aid in the development of new therapies for patients with Friedreich's ataxia. In addition, further study could confirm the presence of mutations in the enzyme that could explain, in part, differing clinical phenotypes among patients.

Dr. Isaya says: "Understanding protein function is central to being able to provide individualized clinical care to patients who may, for example, carry different mutations of this enzyme and express different clinical phenotypes."


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Source:Mayo Clinic


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