Navigation Links
Montreal researchers probe the genetic basis of memory

A group of Montreal researchers has discovered that GCN2, a protein in cells that inhibits the conversion of new information into long-term memory, may be a master regulator of the switch from short-term to long-term memory. Their paper Translational control of hippocampal synaptic plasticity and memory by the eIF2a kinase GCN2, which was published in the August 25th issue of the journal Nature, provides the first genetic evidence that protein synthesis is critical for the regulation of memory formation.

This new discovery is the fruit of an international collaboration. The work of McGill researchers Nahum Sonenberg, Karim Nader, Wayne Sossin and Claudio Cuello, Jean-Claude Lacaille and Nabil Seidah of the Universit?de Montr�al, and David Ron of New York University sheds light on the mysterious workings of the hippocampus, a region of the brain responsible for learning and memory.

"Not all new information we acquire is stored as long-term memory," says Dr. Costa-Mattioli, a post-doctoral fellow in the laboratory of Dr. Sonenberg, who spearheaded the research project. "For example, it takes most people a number of attempts to learn new things, such as memorizing a passage from a book. The first few times we may initially succeed in memorizing the passage, but the memory may not be stored completely in the brain and we will have to study the passage again."

In a series of experiments, the researchers demonstrated that mice bred without the GCN2 protein (known as transgenic mice) acquire new information that does not fade as easily as that of normal mice. This new information is more frequently converted into long-term memory. The researchers concluded that GCN2 may prevent new information from being stored in long-term memory.

Adds Dr.Jean-Claude Lacaille: "The process of switching to long-term memory in the brain requires both the activation of molecules that facilitate memory storage, and the silencing of proteins such as GCN2 tha
'"/>

Source:University of Montreal


Page: 1 2

Related biology news :

1. Montreal researchers identify defects of immune cells
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Montreal researchers probe the genetic basis memory

(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
(Date:8/20/2014)... Tennessee, Knoxville, research finds life can persist in a ... part of a team that examined waters and sediments ... sheet and found the extreme environment supports microbial ecosystems. ... Mikucki and her colleagues has implications for life in ... solar system. The findings are published in the current ...
(Date:8/20/2014)... Using population-based screening outcomes of approximately 3 million infants, ... researchers at the University of Massachusetts Medical School, have ... can be successfully implemented across public health newborn screening ... the Aug. 20 issue of the Journal of ... the rate of SCID in newborns is higher than ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3
... behalf of the European Pet Food Industry Federation (FEDIAF), ... consumption for puppies. The research marks a significant step ... A levels for puppies and sheds new light on ... conducted by scientists from the Free University of Berlin ...
... during the Dust Bowl what a disastrous impact wind ... study has uncovered a less obvious, but still troubling, ... soil particles, but also the beneficial microbes that help ... a powerful DNA sequencing technique, called pyrosequencing, a team ...
... turbine and a meteorological tower recently erected on the ... visible symbol of the University,s commitment to establish a ... Robert Nelson, professors of aerospace and mechanical engineering, are ... Laboratory for Enhanced Wind Energy Design, titled "eWiND." The ...
Cached Biology News:Collaborative research team identifies safe upper level for vitamin A consumption for puppies 2Agricultural bacteria: Blowing in the wind 2Agricultural bacteria: Blowing in the wind 3EWiND facility aimed at improvements in wind energy 2
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
(Date:8/20/2014)... GraphDB™ 6.0 from ... the enterprise replication cluster, faster loading speeds, higher ... Elasticsearch. This release happens to coincide with a ... GraphDB™ was formerly known as OWLIM. ... enterprise resilient RDF triplestore will also benefit from ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
(Date:8/19/2014)... , Aug. 19, 2014 A Geisinger ... been nominated for a Centers for Disease Control and ... a major public health concern. Joseph ... is one of a team of researchers nominated for ... C. Shepard Science Award for Data Methods and Study ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... N.J., Feb. 24, 2011 Palatin Technologies, Inc. (NYSE Amex: ... underwritten public offering of 23,000,000 units, consisting of 23,000,000 shares ... shares of its common stock and Series B Warrants to ... to the public of $1.00 per unit. Palatin expects that ...
... ) today announced that management will present at the following conferences: ... 2, 2011 at 2:30 p.m. ET RBC Capital Markets, Healthcare Conference, ... Cowen Annual Healthcare Conference, Boston, MA on March 8, 2011 at 11:00 ... on March 14, 2011 at 10:00 a.m. PT ...
... This release is available in German . ... electronics for a long time, and now they are making ... no longer only used in cell phones and digital cameras. ... optical semiconductor chips and is increasingly using them in driver ...
Cached Biology Technology:Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 2Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 3UV-transparent coating for image sensors 2
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... to Asparagine synthetase ( Abpromise ... Antigen: ... in the C-terminus of Human ... Entrez GeneID: 440 ...
Biology Products: