Navigation Links
Montreal researchers probe the genetic basis of memory

A group of Montreal researchers has discovered that GCN2, a protein in cells that inhibits the conversion of new information into long-term memory, may be a master regulator of the switch from short-term to long-term memory. Their paper Translational control of hippocampal synaptic plasticity and memory by the eIF2a kinase GCN2, which was published in the August 25th issue of the journal Nature, provides the first genetic evidence that protein synthesis is critical for the regulation of memory formation.

This new discovery is the fruit of an international collaboration. The work of McGill researchers Nahum Sonenberg, Karim Nader, Wayne Sossin and Claudio Cuello, Jean-Claude Lacaille and Nabil Seidah of the Universit?de Montr�al, and David Ron of New York University sheds light on the mysterious workings of the hippocampus, a region of the brain responsible for learning and memory.

"Not all new information we acquire is stored as long-term memory," says Dr. Costa-Mattioli, a post-doctoral fellow in the laboratory of Dr. Sonenberg, who spearheaded the research project. "For example, it takes most people a number of attempts to learn new things, such as memorizing a passage from a book. The first few times we may initially succeed in memorizing the passage, but the memory may not be stored completely in the brain and we will have to study the passage again."

In a series of experiments, the researchers demonstrated that mice bred without the GCN2 protein (known as transgenic mice) acquire new information that does not fade as easily as that of normal mice. This new information is more frequently converted into long-term memory. The researchers concluded that GCN2 may prevent new information from being stored in long-term memory.

Adds Dr.Jean-Claude Lacaille: "The process of switching to long-term memory in the brain requires both the activation of molecules that facilitate memory storage, and the silencing of proteins such as GCN2 tha t inhibit memory storage."

Although research on humans is still a distant possibility, the scientists believe their discovery may hold promise in the treatment of a variety of illnesses linked to memory. "The discovery of the role of GCN2 in long-term memory may help us develop targeted drugs designed to enhance memory in patients with memory loss due to illnesses such as Alzheimer's disease, where protein synthesis and memory are impaired," concludes Dr. Karim Nader.


'"/>

Source:University of Montreal


Related biology news :

1. Montreal researchers identify defects of immune cells
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2016)... PUNE, India , March 11, 2016 ... to a new market research report "Image Recognition Market ... by Application (Marketing and Advertising), by Deployment Type (On-Premises ... Global Forecast To 2022", published by MarketsandMarkets, the global ... in 2015 to USD 29.98 Billion by 2020, at ...
(Date:3/9/2016)... , March 9, 2016 ... identified that more than 23,000 public service employees either ... been receiving their salary unlawfully.    --> ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ...
(Date:3/3/2016)... MONTEREY, Calif. , March 3, 2016 /PRNewswire/ ... Partner, launched this week highlighting advancements in flexible, ... – a record setting attendance - have gathered ... in this fast-growing field of electronics. The Flex ... a focal point for companies, R&D organizations, and ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... Columbia , April 27, 2016 ... "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... Anschluss an ihre Pressemitteilung vom 13. August 2015 ... hat, ihre Finanzen um zusätzliche 200.000.000 Einheiten auf ... Kanadische Dollar zu bringen. Davon wurden 157.900.000 Einheiten ...
(Date:4/27/2016)... ... 2016 , ... PathSensors, Inc., a leading environmental testing company, ... assist PathSensors in expanding the use of the company’s CANARY® technology in the ... for the detection of harmful pathogens, including a number of bacteria, viruses, toxins, ...
(Date:4/27/2016)... 27, 2016 MedDay, a biotechnology company ... the appointment of Catherine Moukheibir as Chairman of its Board ... Jean Jacques Garaud , who contributed to the rapid ... immediately. Catherine started her career in strategy consulting ... London .  She held C-Suite level roles ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office ... as one of three finalists for the European Inventor Award 2016 in the category ... will be announced at a ceremony in Lisbon on June 9th. , The human ...
Breaking Biology Technology: