Navigation Links
Monkeypox mystery: New research may explain why 2003 outbreak in the US wasn't deadly

An outbreak of 72 cases of monkeypox in the United States during the summer of 2003 didn't produce a single fatality, even though the disease usually kills 10 percent of those infected.

Why did none of the patients die? New research from Saint Louis University Health Sciences Center and several partner institutions may provide an answer.

In this month's issue of Virology, researcher and senior author Mark Buller, Ph.D., from Saint Louis University Health Sciences Center and colleagues conclude that some strains of monkeypox are more virulent than others, depending on where in Africa the virus came from.

"We have at least two biological strains of monkeypox virus - one on the west coast of Africa, and the other in the Congo basin," Buller said. "The 2003 outbreak in the United States was from West Africa. If it had come from Congo, we might have had a bigger problem on our hands and very well might have seen patient deaths."

Researchers from the University of Victoria, Washington University School of Medicine, U.S. Army Research Institute of Infectious Diseases, the University of Alabama, East Carolina University and the Centers for Disease Control and Prevention are co-authors of the research.

Buller said that recent studies suggest the incidence of monkeypox is increasing due to encroachment of human into habitats of animal reservoirs. Monkeypox is classified as a "zoonosis," which means that it is a disease of animals that can be transmitted to humans under natural conditions. The first cases of monkeypox reported in humans involved contact between humans and animals in Africa.

The first outbreak of monkeypox in the Western hemisphere occurred in the U.S. Midwest from April to June of 2003. The virus entered the U.S. in a shipment of African rodents from Ghana in West Africa destined for the pet trade. At a pet distribution center, prairie dogs became infected and were responsible for 72 confirmed or suspected cases o f human monkeypox.

"Unlike African outbreaks, the U.S. outbreak resulted in no fatalities and there was no documented human-to-human transmission," Buller said.

Monkeypox is part of a family of viruses that cause human smallpox, cowpox, and camelpox as well as monkeypox. Monkeypox usually produces a less severe illness with fewer fatalities than smallpox. But its symptoms are similar: fever, pus-filled blisters all over the body, and respiratory problems.

"Our finding may explain the lack of case-fatalities in the 2003 monkeypox outbreak in the United States, which was caused by a West African virus," Buller said.


'"/>

Source:Saint Louis University


Related biology news :

1. Evolution mystery: Spider venom and bacteria share same toxin
2. Columbia research lifts major hurdle to gene therapy for cancer
3. U of M researcher examines newly emerging deadly disease
4. NYU researchers simulate molecular biological clock
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. New research questions basic tenet of neuron function
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
11. New protein discovered by Hebrew University researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... , May 2, 2016 Q ... its technology partner Mannin Research Inc. will be attending ... which takes place from May 1-5, 2016 in ... be meeting with its vendors and research partners. The ... development goals and other collaborative opportunities for the MAN-01 ...
(Date:5/2/2016)... ... 2016 , ... F.E.E.D. Co., the Feline Environmental Enrichment Design ... product for indoor cats. The NoBowl Feeding System replaces the bowl with the ... nature intended. NoBowls make cats happy and healthy. , Since being introduced on ...
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., a leading ... today announced the completion of a significant transaction and partnership that positions Amendia ... and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private equity firm ...
(Date:4/29/2016)... KY and San Diego, CA (PRWEB) , ... April 29, 2016 ... ... National Stem Cell Foundation (NSCF) to support the development of a patient-specific stem cell ... Dr. Andrés Bratt-Leal in the lab of Dr. Jeanne Loring at The Scripps Research ...
Breaking Biology Technology: