Navigation Links
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

A molecule that usually protects the body's infection-fighting cells might also contribute to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researchers have found.

The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in macrophages, which circulate in the bloodstream and help the body fend off infection and foreign substances. The AIM-protected macrophages go on to encourage buildup of fats on the interior walls of arteries, according to Dr. Toru Miyazaki, senior author of a study that appears in the March issue of the journal Cell Metabolism.

"We found that AIM is highly expressed in certain macrophages and that lack of AIM dramatically decreased early atherosclerotic lesion development in mice," Dr. Miyazaki said. "These results may imply a novel therapeutic application of AIM regulation for prevention of atherosclerosis in the future. Most importantly and attractively for patients, this approach may not need dietary restriction."

Dr. Miyazaki, associate professor in the Center for Immunology and of pathology, and his colleagues first discovered the protective role of AIM six years ago. In the current study, scientists exposed mice lacking AIM to a fatty diet that would normally induce atherosclerosis.

After several weeks, researchers found little to no atherosclerotic lesions. Comparatively, in mice that had normal AIM function, there was marked presence of plaque deposits in the arteries following a diet of high-fat food.

"This was dramatic evidence that showed suppressing AIM function translates into prevention of atherosclerosis," Dr. Miyazaki said.

Atherosclerosis, known as "hardening of the arteries," occurs when the inside walls of an artery become thicker and less elastic.

This narrows the space for blood flow and can lead to angina and heart attacks in some people. Fatty buildups occur on the inner lining of an artery and grad
'"/>

Source:University of Texas Southwestern Medical Center at Dallas


Page: 1 2

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Touching Molecules With Your Bare Hands
5. Team Invents Device For Weighing Individual Molecules
6. Missing Receptor Molecule Causes Tumor Growth
7. Molecule by molecule, new assay shows real-time gene activity
8. Molecule does more than slice and dice RNA
9. Molecules in blood foretell development of preeclampsia
10. Molecule that destroys bone also protects it, new research shows
11. Bound for destruction: Ubiquitination protects against improper Notch signaling
Post Your Comments:
(Date:7/11/2014)... researchers from The Chinese University of Hong Kong, BGI ... soybean linked to salt tolerance, with implication for improving ... study published online in Nature Communications provides ... crop improvement. , Soybean is an important crop for ... soybeans have less genetic diversities than their wild counterparts. ...
(Date:7/11/2014)... Researchers have pioneered a revolutionary new way to ... Virtual Finger, allows scientists to move through digital ... using the flat surface of their computer screens. ... orders of magnitude more efficient, saving time, money ... areas of experimental biology. The software and its ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... for benefiting degenerative diseases, and do so by invoking ... manner compatible with clinical use (i.e., without animal feeder ... were a few of a number of conclusions arrived ... Snyder, M.D., Ph.D., and spearheaded by a member of ...
... ability to discern one sex from another may depend ... nerve cells, and the number of receptors is controlled ... Illinois at Chicago researchers have found. , Everything from ... illnesses such as amyotrophic lateral sclerosis, muscular dystrophy, post-traumatic ...
... the first large-scale study to evaluate a candidate HIV ... study collaborators in the United States and South Africa. ... five sites throughout South Africa and is expected to ... of the HIV Vaccine Trials Network (HVTN), which is ...
Cached Biology News:Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 2Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 3Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 4Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease 5Bisexual fruit flies show new role for neurochemical 2Africa's first large-scale HIV vaccine study launches 2Africa's first large-scale HIV vaccine study launches 3Africa's first large-scale HIV vaccine study launches 4
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, ... announce the relaunch of his highly informative blog, now named ... “ What are Stem Cells ?” Dr. Harman’s purpose ... in the basics of stem cell therapy so that pet ... of treatment when considering regenerative medicine. , A veterinarian by ...
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
(Date:7/10/2014)... researchers have observed the fractional quantum Hall effect in ... matter can be tuned by an electric field. ... when electrons confined to thin sheets are exposed to ... behavior where thousands of individual electrons behave as a ... effect is well established, many details of this collective ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... North ... America, DEERFIELD, Ill., ... Cartago, Costa Rica has been,recognized with the 2008 Shingo Prize for Operational ... North America,-- is being honored for its achievements in driving higher quality ...
... announced today it,submitted to the U.S. Food & ... Application (BLA) for motavizumab, an investigational,monoclonal antibody (MAb) ... supported by clinical trial data from more than ... of serious disease,caused by respiratory syncytial virus (RSV) ...
... Unique and Innovative Formulation Available Without a ... Prescription ... today announced the,launch of PSORENT, a clinically proven, steroid-free, ... which has,proven efficacy against psoriasis symptoms, in a novel, ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2MedImmune Submits Biologics License Application to FDA for Motavizumab 2MedImmune Submits Biologics License Application to FDA for Motavizumab 3NeoStrata(R) Announces the Launch of PSORENT(TM) Psoriasis Topical Treatment 2