Navigation Links
Molecule that destroys bone also protects it, new research shows

posite result. The mice without IL-17 were much more susceptible to bone loss caused by periodontal disease, compared to normal mice.

"What’s the difference between an autoimmune disease like RA and periodontal disease" Periodontal disease is an infectious disease, and as with most infectious diseases, white blood cells of the innate immune system called neutrophils play a critical role in fighting infections. In fact, humans with neutrophil defects usually lose all their teeth by the time they are 20 due to severe periodontal disease.

"It turns out that IL-17 is really important in regulating neutrophils by causing other cells in the vicinity to recruit these infection fighters to the infection site," Gaffen said.

IL-17 is a cytokine, a protein hormone made by "T helper" cells of the immune system that stimulate immunity. Gaffen noted that until recently, immunologists believed there were only two major types of "T helper" cells -- TH1 and TH2 -- which were believed to be responsible for nearly all immune system activities.

"This paradigm underwent a sea change in 2005 with the discovery of a new type of T cell that produces IL-17, now called TH-17," she said. "We know now that almost all autoimmune diseases, at least in the mouse model, are caused by TH-17 cells. This new information has forced scientists to revise completely how they view their favorite disease. Everyone now has to rethink the causative mechanism."

Gaffen said IL-17 likely would be toxic if given systemically, so it may not be a therapeutic candidate to increase immunity. But inhibitors of IL-17 are considered important targets for drugs to treat autoimmune diseases such as RA and psoriasis.

On the down side, however, this new finding indicates that inhibiting IL-17 too much could put people taking such a drug at risk for opportunistic infections such as periodontal disease and tuberculosis, she noted.

"Developin
'"/>

Source:University at Buffalo


Page: 1 2 3

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
4. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
5. Touching Molecules With Your Bare Hands
6. Team Invents Device For Weighing Individual Molecules
7. Missing Receptor Molecule Causes Tumor Growth
8. Molecule by molecule, new assay shows real-time gene activity
9. Molecule does more than slice and dice RNA
10. Molecules in blood foretell development of preeclampsia
11. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecule that destroys bone also protects new research shows

(Date:7/28/2014)... Kansas He calls himself the bug hunter, but ... can only be found and identified with special methods ... the Kansas State Veterinary Diagnostic Laboratory at Kansas State ... discoveries, porcine enterovirus G, which is an important find ... virus in cells, but didn,t know what it was," ...
(Date:7/28/2014)... Rice University researchers are using magnetic beads and DNA ... be used as microscale models for polymer macromolecules. , ... as theory in the 1950s, can be made as ... of interest to materials scientists who study the basic ... chemical and biomolecular engineer Sibani Lisa Biswal and graduate ...
(Date:7/28/2014)... A powerful new tool that can help advance ... green and renewable bioenergy, has been developed by ... Joint BioEnergy Institute (JBEI), a multi-institutional partnership led ... JBEI researchers have developed an assay that enables ... nucleotide sugar transporters, critical components in the biosynthesis ...
Breaking Biology News(10 mins):Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Seeing is bead-lieving 2How sweet it is 2How sweet it is 3
... ability of the brain to recover from such injury as ... that "talk" to one another using the brain chemical acetylcholine, ... Neural repair Group at UCSD have discovered. Their finding in ... by leading to the development of drugs or other treatments ...
... membrane. The membrane is studded with many hundreds of ... and out of the cell. Such membrane proteins also ... make the nervous system work. Scientists at Stockholm University ... proteins in the enteric bacterium Escherichia coli. Their study ...
... expression must be standardized among laboratories and across platforms ... genome exploration, an Oregon Health & Science University researcher ... as gene chips, risk having their research results called ... in the OHSU School of Medicine. , Spencer, director ...
Cached Biology News:Brain-injury rehabilitation depends on acetylcholine circuitry 2Study: 'homemade' gene expression technology unreliable 2Study: 'homemade' gene expression technology unreliable 3
(Date:7/29/2014)... 2014 Genera Energy Inc. ... innovation and supply chain advancements, has announced the ... Energy Grange™ and Supply ASSURE™. Both systems ... testing aimed at consolidating and simplifying the entire ... farmers and feedstock end users. , “Through the ...
(Date:7/29/2014)... July 29, 2014 Quorum Review ... has been awarded accreditation by the International ... its Lean Six Sigma Deployment Program. The citation ... improve performance. , Quorum’s Lean Six Sigma program ... Deployment Program designation. The designation is a public ...
(Date:7/29/2014)... July 29, 2014 The first product ... next generation approach to robotics. What sets Droidles completely ... pending technology that allows them to communicate, share code ... over the internet. , “The invention is the system,” ... little Droidles a life of their own, both physically ...
(Date:7/29/2014)... Dr. Jason Wendel – recipient of a Regional Top ... Top 10 Plastic Surgeon Specialists for Nashville, TN – has ... line includes a Hydration Booster, Retexturing Night Crème, and Anti-aging ... a younger, more radiant appearance while protecting them from the ... is why at Dr. J. J. Wendel Plastic Surgery, we ...
Breaking Biology Technology:Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2Dr. J. J. Wendel Launches New Line of Skin Care Products 2
... , , Udo Reischl and Christian Gerdes, Institute of ... , ... virus (EBV) infection is currently based , ... years the specificity and sensitivity of serodiagnostic ...
... Introduction , ... or probes in genetic analysis. Quality control of these preparations ... electrophoresis or HPLC, but these , methods may ... not provide desired quantitative precision or automation. Capillary electrophorsis , ...
... Guy C. Le Breton, Department of Pharmacology,University of Illinois at Chicago, College of ... Pharmacology M/C 868, University of Illinois at Chicago, Chicago, IL 60612.,E-mail: jturek1@icarus.uic.edu , ... Introduction , ... receptor, in addition to its , ...
Cached Biology Technology:Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 2Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 3Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 4Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 5Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 6Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 7Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C 8Oligonucleotide Purity Analysis by Capillary Electrophoresis 2Oligonucleotide Purity Analysis by Capillary Electrophoresis 3Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A 2Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A 3Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A 4Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A 5
... materials necessary for the isolation and preparation of ... Kit Components: Erythrocyte ... containing 220 mL of buffered ammonium chloride. (NH ... No. 5113) One bottle containing 220 mL of ...
nuclear cap binding protein subunit 1, 80kDa, mRNA...
Protein Phosphorylation...
MOUSE ANTI S. NEWPORT SALMONELLA HADAR...
Biology Products: