Navigation Links
Molecule that destroys bone also protects it, new research shows

An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.

The component, IL-17, was recognized only in the past 18 months to be a primary cause of bone destruction and inflammation in autoimmune diseases. Therapies that target IL-17 or its cellular receptor currently are being developed.

However, a UB molecular biologist has discovered that, in contrast to its action in rheumatoid arthritis(RA), IL-17 actually protects bone in the oral cavity from infectious pathogens such as Porphyromonas gingivalis, a bacterium that plays a major role in most periodontal disease in humans.

The research findings appear in the current (May) issue of the journal Blood.

Sarah L. Gaffen, Ph.D., associate professor of oral biology in the UB School of Dental Medicine and associate professor of microbiology and immunology in the UB School of Medicine and Biomedical Sciences, is senior author. Jeffrey J. Yu, a medical student and doctoral candidate who is a researcher working in Gaffen’s lab, is first author.

Gaffen and colleagues conducted the research in mice bred to have no receptors for IL-17. Other researchers had shown previously, using rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and possibly for other autoimmune diseases such as multiple sclerosis, colitis, psoriasis and lupus.

The effects of an IL-17 deficiency in periodontal disease, however, were unknown, so Gaffen’s lab set out to investigate.

"I predicted these mice without the IL-17 receptor were going to be protected from periodontal bone loss, just like they’re protected from arthritic bone loss," Gaffen said. "In fact, we got the op
'"/>

Source:University at Buffalo


Page: 1 2 3

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
4. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
5. Touching Molecules With Your Bare Hands
6. Team Invents Device For Weighing Individual Molecules
7. Missing Receptor Molecule Causes Tumor Growth
8. Molecule by molecule, new assay shows real-time gene activity
9. Molecule does more than slice and dice RNA
10. Molecules in blood foretell development of preeclampsia
11. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecule that destroys bone also protects new research shows

(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... often stop to ogle the country's many saltwater lagoons, ... admire these saltern crystallizers--and even more so, the microbes ... reporting in the November 28-December 2 early online edition ... researchers at The Institute for Genomic Research and collaborators ...
... A laboratory study has uncovered new details about how estrogen ... or tumors. The results raise the possibility that estrogen therapy ... study appears in the December 7 issue of the ... , When cancer treatments such as chemotherapy or hormonal ...
... lives could be saved in the United States by ... more on getting existing treatments to the patients who ... Virginia Commonwealth University family medicine and public health physician. ... of Health to develop blockbuster treatments, it spends only ...
Cached Biology News:A salty tale: New bacterial genome sequenced from ancient salterns 2 Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer 2Access to existing medical treatments could save more lives than spending to improve the treatments 2Access to existing medical treatments could save more lives than spending to improve the treatments 3
(Date:4/23/2015)... Athena San Diego, an organization that accelerates ... San Diego’s technology and life science sectors, will announce ... their Gala on April 30, 2015 from 5-9pm at ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals and ... of fostering networking, risk taking and diversity of thought, ...
(Date:4/23/2015)... April 23, 2015 /CNW/ - A new and innovative ... from North America,s largest ... won Silver in the "Sustainability, service" category of ... Brandcheck "Competitor Comparison" is a service that scores ... and Global peers. This benchmarking process shows clients ...
(Date:4/23/2015)... D.C. (PRWEB) April 23, 2015 ... D.C. region on April 4-17 as part of ... marks the fourth group of biotechnology startups to ... of Nizhny Novgorod (UNN) and the University of ... deepen ties between their respective universities in the ...
(Date:4/23/2015)... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ), ... serving the pharmaceutical, biotechnology and medical device industries, with ... the United States , today announced that ... of 2015 after the New York Stock Exchange closes ... morning, May 14, 2015 Shanghai time). The earnings release ...
Breaking Biology Technology:Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 3
... BRIDGEWATER, N.J., May 28 Sanofi-aventis U.S. announced today ... and the U.S. Attorney,s Office for the District of ... investigation involving one of its predecessor companies, ... whether sales by API of certain products to a ...
... Inc., a newly formed wholly-owned subsidiary of San Diego-based ... today the launch of its Web site ( ... stem cell research, including a proposed research to develop ... using autologous adipose-derived (fat) stem cells representing a potential ...
... ("MedMira") (TSX Venture: MIR, NASDAQ: MMIRF ), ... solutions, announced today that VWR International, LLC (VWR) has ... Chester, Pennsylvania, VWR is a global laboratory supply and ... billion. , "The U.S. is an important market for ...
Cached Biology Technology:Sanofi-aventis U.S. Announces Settlement of Medicaid 'Best Price' Investigation 2New Stem Cell Web Site to Focus on Traumatic Brain Injury, Spinal Cord Injury and Diabetes 2MedMira Strengthens North American Sales Channels, Adding VWR as Distributor for the United States 2
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
... acid hybridization Preparation Reconstitution: one ... 50 mg ficoll and 50 ... ml of water yields a ... biology Density: 1.00 g/mL (20 ...
... The Vibratome Company has joined forces with ... the Vibratome 800 Tissue Chopper. This tissue ... sections of tissue for metabolic experiments and ... irregular specimens available at biopsy or from ...
... EvoQuest Custom Peptide Services offer a ... meet your research needs. Services include: ... Peptide synthesis, purified product ... modifications (acetylation, amidation, biotinylation, fluorescein, myristylation, phosphorylation, ...
Biology Products: