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Molecular steps involved in the creation of gene-silencing microRNAs identified

ated here. Equally as important, however, is the fact that while two of the proteins had been associated with miRNAs in earlier work, the third protein, TRBP, had not been. And TRBP is clearly a protein of interest to scientists.

"TRBP was first observed as a protein that binds to HIV during transcription of the virus," says Shiekhattar. "The tantalizing implication is that the RNA interference pathway may play a significant role in HIV replication. TRBP has also been identified as a tumor suppressor, which suggests still other connections to be explored."

The lead authors on the Nature study are Thimmaiah Chendrimada, Richard I. Gregory, and Easwari Kumaraswamy, with each contributing equally to the work. The remaining co-authors are Jessica Norman, Neil Cooch, and Wistar professor Kazuko Nishikura, Ph.D. Corresponding author Shiekhattar is an associate professor in two programs at Wistar, the gene expression and regulation program and molecular and cellular oncogenesis program. Support for the research was provided by the National Institutes of Health, the American Cancer Society, and the Jane Coffin Child Memorial Fund for Medical Research.


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Source:The Wistar Institute


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