Navigation Links
Molecular 'signature' protects cells from viruses

Every cell constantly produces a whole arsenal of proteins. The instruction what is to be built comes from the cell nucleus: this is where the DNA is stored, the heredity molecule in which, so to speak, the construction blueprints for all cellular proteins are stored. If a particular protein is to be produced, the appropriate command is 'copied' in the cell nucleus. The copy consists of a DNA-like substance, the RNA. Via pores in the cell nucleus it reaches the cell plasma. The individual parts of the desired protein are put together there on a kind of assembly line. In this process the assembly line follows exactly the blueprint which is stored in the relevant RNA.

This method has an Achilles heel: 'enemies' can misuse the assembly line to produce their own proteins by faking the commands. Viruses, for example, basically consist of a small protein capsule which surrounds its genetic make-up ?usually an RNA molecule. This RNA mainly contains the blueprint for new capsule proteins. By injecting its RNA into the cell, the virus re-programmes it: the cell production line then produces large numbers of new virus capsules. These are filled with virus RNA and attack more cells.

'However, the cells are not completely at the mercy of a virus attack,' Professor Gunther Hartmann, head of the Bonn University Clinic's Department of Clinical Pharmacology. 'They often recognise the alien RNA and set off the alarm: for example, they then produce what is known as the beta interferon, thereby activating specific killer cells. They also initiate the cell's suicide programme ?apoptosis. The viruses cannot then continue to breed.'

Up to now it was not known how cells distinguish their own RNA from that of the 'enemy'. The latest findings, which a Japanese research team was also involved in, now shed light on the matter: they show that the instructions from the cell's nucleus carry a kind of 'signature', which is missing in the virus commands. RNA is like a l
'"/>

Source:University of Bonn


Page: 1 2

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Molecular machine may lead to new drugs to combat human diseases
3. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
4. Molecular models advance the fight against malaria
5. Molecular fossils uncover link between viruses and the immune system
6. Molecular thermometers on skin cells detect heat and camphor
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Molecular steps involved in the creation of gene-silencing microRNAs identified
9. Molecular miners find pain relief drugs from the sea
10. Molecular mechanism of feather formation found
11. Molecular trigger for Huntingtons disease found
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular signature protects cells from viruses

(Date:4/24/2014)... Carbon offsetting initiatives could be improved with new insights ... , Scientists studying the Amazon Basin have revealed ... trees across the region by comparing satellite maps with ... enable researchers to assess more accurately the amount of ... factor in carbon offset schemes, in which trees are ...
(Date:4/24/2014)... turtle in North America, weighing in at up to ... from Florida and the University of Vermont have discovered ... , Examining museum specimens and wild turtles, the scientists ... Once heavily hunted for turtle meat alligator snapper ... the 1960s the riverine populations have been deeply ...
(Date:4/24/2014)... out a welcome mat to bacteria seeking to invade, and ... published this week in the Proceedings of the National ... between microbe and host that researchers can exploit to protect ... plant Arabidopsis puts out a molecular signal that ... hostile army were unknowingly passing by a castle, and the ...
Breaking Biology News(10 mins):Amazon rainforest survey could improve carbon offset schemes 2Two new US turtle species described 2Two new US turtle species described 3How a plant beckons the bacteria that will do it harm 2How a plant beckons the bacteria that will do it harm 3
... Current arthritis medications can ease the pain, but ... aggressive treatments: use of very limited available drugs ... to find new therapeutic targets for arthritis by ... interrupted, may prevent arthritis pain caused by joint ...
... More than 300 people and 30 companies are expected ... career fair on March 13, 2009 at NJIT. The ... 3:30 p.m. in NJIT,s Campus Center, unites industry professionals ... "Explore the Leading Edge of the ...
... by the Wildlife Conservation Society, have helped the government ... protect more than 600 gorillas, along with other threatened ... Called Deng Deng National Park, the new ... kilometers) in sizeapproximately the size of the City of ...
Cached Biology News:Inhibiting proteins may prevent cartilage breakdown in arthritis patients 2NJIT to host major biomedical engineering showcase and career fair 2Wildlife Conservation Society helps Cameroon create new national park 2Wildlife Conservation Society helps Cameroon create new national park 3
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... March 25 Alseres,Pharmaceuticals, Inc. (Nasdaq: ALSE ) ... on Tuesday, April 1st, 2008 at 10:00am EDT to ... the Company., To access the conference call, please ... this conference call is,7767549. Please dial in 5 to ...
... PALO ALTO, Calif., March 25 Varian Medical,Systems (NYSE: VAR ) ... 2008 following the close of regular trading on,Wednesday, April 23, 2008. The ... at 2:00 p.m. PT., , The Varian Medical Systems quarterly results ... Contact Anne Rambo via phone at 650-424-5834 or ...
... Codexis, Inc., today,announced the appointment of David Anton, ... Research and Development. He,joins Codexis from DuPont, where ... Alan Shaw, Ph.D., President and CEO., "Codexis ... technology can make a significant impact," said Alan ...
Cached Biology Technology:Alseres Pharmaceuticals to Host 2007 Financial Results Conference Call 2Alseres Pharmaceuticals to Host 2007 Financial Results Conference Call 3Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 2Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 3Codexis Names David Anton VP Bioindustrials R&D 2
Recombinant Rhesus Monkey IFN-Alpha...
2,4-Dinitrophenyl hapten is conjugated to BSA (Bovine Serum Albumin) protein through lysine....
4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
Biology Products: