Navigation Links
Molecular motors and brakes work together in cells

Researchers at the University of Pennsylvania School of Medicine have discovered that microtubules -- components responsible for shape, movement, and replication within cells -- use proteins that act as molecular motors and brakes to organize into their correct structure. If microtubules are not formed properly such basic functions as cell division and transport can go wrong, which may have implications in such disease processes as cancer and dementia. The study, published in the January issue of Cell, is featured on the cover of that issue.

"Up until now motors and brakes were studied separately from microtubules," says senior author Phong Tran, PhD, Assistant Professor of Cell and Developmental Biology. "This study lets us have a more complete picture."

Microtubules are structures that help give shape to many types of cells, form the spindle -- a structure important in cell division -- and act as a railroad, of sorts, upon which molecular motors move protein packages for waste removal and nerve transmission.

In the Cell study, the investigators, working with fission yeast cells, showed that stable end-to-end arrays of microtubules can be achieved by a balance between the sliding by a molecular motor called klp2p and the braking of a microtubule-associated protein (MAP) called ase1p. Specifically, they showed that a preexisting "mother" microtubule acts as a platform on which a new microtubule can be formed. The new "daughter" microtubule grows and moves along the mother microtubule. In time, the daughter grows beyond the end of the mother to ultimately produce two microtubules, connected by the cross-linking MAP ase1p.

"Imagine that the daughter microtubule is a short train on the track of the mother microtubule," explains Tran. "The molecular motor is the train's engine, but the problem is that the cargo -- the molecular brakes -- gets longer, slowing down the daughter train. But when the train gets to the end of the trac k it remains attached to the end of mother microtubule. At the tail end, it stops moving and that defines the region of overlap. Our work shows that the cell can make microtubule structures of defined lengths stable by coordinating the sliding of the motors and the slowing of the brakes."

If microtubule-based structures are not formed properly because of failures in brakes or motors, such basic functions as cell division and cell transport can go awry, with such diseases as cancer and dementia possibly resulting. "For the first time we have shown how MAPs and motors work together in a mechanistic way," says Tran. "This is important and it will make other people who study microtubules rethink how they study the cell."
'"/>

Source:University of Pennsylvania School of Medicine


Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Molecular machine may lead to new drugs to combat human diseases
3. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
4. Molecular models advance the fight against malaria
5. Molecular fossils uncover link between viruses and the immune system
6. Molecular thermometers on skin cells detect heat and camphor
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Molecular steps involved in the creation of gene-silencing microRNAs identified
9. Molecular miners find pain relief drugs from the sea
10. Molecular mechanism of feather formation found
11. Molecular trigger for Huntingtons disease found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... GENOA, Italy , May 23, 2017  Hunova, the first robotic ... and trunk, has been officially launched in Genoa, Italy ... Europe and the USA . The ... launched on the market by the IIT spin-off Movendo Technology thanks to ... view the Multimedia News Release, please click: ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... London, June 28, 2017 (PRWEB) , ... ... ... The latest release of Siemens’ STAR-CCM+® software for multiphysics computational fluid dynamics ... automated product design exploration and optimization. STAR-CCM+ version 12.04 introduces Design Manager, ...
(Date:6/28/2017)... ... 28, 2017 , ... Studies indicate that replacing damaged brain cells with those ... disease. But what has not been determined is the optimal stage during differentiation of ... , A new study coming out of Singapore, recently published in STEM CELLS Translational ...
(Date:6/27/2017)... AZ (PRWEB) , ... June 27, 2017 , ... ... world’s first brain mirroring wellness product via Kickstarter campaign on June 15th to ... have already pre-ordered the B2v2, exceeding the original Kickstarter goal by more than ...
(Date:6/27/2017)... ... 27, 2017 , ... According to a recent report from ... not have negative short- or long-term effects on benthic communities. , The ... located at the Puget Sound Naval Shipyard & Intermediate Maintenance Facility in Bremerton, ...
Breaking Biology Technology: