Navigation Links
Molecular models advance the fight against malaria

te and study the respiratory enzyme cytochrome bc1 complex, which the parasites need to live and multiply. A protein subunit of the bc1 complex is where the malaria parasite mutates to counter anti-malarial drug therapies. Yeast is an effective resource because it can be safely grown in large quantities and can be easily modified to take on the qualities of more dangerous pathogens, without risking human infection.

When the researchers genetically transferred mutations into the yeast surrogates, the yeast acquired resistance to atovaquone just as the malaria parasites had done. The team was then able to apply computerized modeling techniques to illustrate exactly how the drug interacted with the cytochrome bc1 complex ?the respiratory enzyme the parasites need to live and multiply -- on a molecular level. With this new understanding of how the parasites were able to counter the effects of atovaquone, researchers can now design new anti-malarial drugs with features making the appearance of resistance more unlikely.

"Within the next 3-5 years, we hope to develop a new drug that will finally empower us to treat this terrible disease," said Trumpower.

Dartmouth Medical School co-authors of the paper are Dr. Jacques Kessl, research associate in biochemistry, Kevin Ha, Anne Merritt and Benjamin Lange. Other co-authors are Dr. Brigitte Meunier and Philip Hill from the Wolfson Institute for Biomedical Research in London and Dr. Steven Meshnick from the University of North Carolina, Chapel Hill.


'"/>

Source:Dartmouth Medical School


Page: 1 2

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Molecular machine may lead to new drugs to combat human diseases
3. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
4. Molecular fossils uncover link between viruses and the immune system
5. Molecular thermometers on skin cells detect heat and camphor
6. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
7. Molecular steps involved in the creation of gene-silencing microRNAs identified
8. Molecular miners find pain relief drugs from the sea
9. Molecular mechanism of feather formation found
10. Molecular trigger for Huntingtons disease found
11. Molecular Partners Required For Appropriate Neuronal Gene Repression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular models advance the fight against malaria

(Date:7/30/2014)... pledge of $1 million from the Cornelia Cogswell Rossi ... Biometry Center. , The newly established Connie ... to develop a greater breadth and depth of knowledge ... the pace of research to improve human health. , ... for the Laboratory and its external partners, supporting research ...
(Date:7/30/2014)... ranges and a changing climate threaten some of ... and so conservationists establish seed collections to save ... hopes of preserving some genetic diversity., For decades, ... models that offer a one-size-fits-all approach for how ... 50 seed samples regardless of species, pollination mode, ...
(Date:7/30/2014)... from Bjorn Brembs, professor of neurogenetics at the Institute ... figure allowing readers and reviewers to run the underlying ... important leap forward for scientific publishing, by demonstrating a ... scholarly output. , Figure 3 in fact doesn,t really ... to F1000Research , and the figure is generated ...
Breaking Biology News(10 mins):Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Saving seeds the right way can save the world's plants 2F1000Research brings static research figures to life 2
... have so far won 19 grants worth a total of ... Recovery and Reinvestment Act. The grants range from $2 ... produce biological hydrocarbons for biofuels to $600,000 for a study ... the Ebola virus can inhibit a body,s antiviral response. Fifteen ...
... gene defect in mice has helped identify a new protein ... study by University of Iowa and Kansas State University researchers. ... open-access journal PLoS Genetics . In humans, ... yet most genes involved in hearing are unidentified. Mice are ...
... book demystifies bats and eliminates many myths surrounding rabies ... Lyssavirus Infections , combines current science about bat rabies ... The author, Denny G. Constantine, is widely considered one ... Rabies is intended for scientists and the general public. ...
Cached Biology News:Iowa State faculty attract $4.8 million in American Recovery and Reinvestment Act grants 2Iowa State faculty attract $4.8 million in American Recovery and Reinvestment Act grants 3Iowa State faculty attract $4.8 million in American Recovery and Reinvestment Act grants 4Forget the garlic necklace -- learn more about bats and rabies 2
(Date:7/30/2014)... July 30, 2014   Epic Sciences, Inc. ... novel diagnostics to personalize and advance the treatment and ... Gregory T. Lucier as chairman of Epic,s board ... of Life Technologies (formerly Invitrogen). Mr. Lucier joins Epic,s ... its circulating rare cell analysis platform with special focus ...
(Date:7/30/2014)... July 30, 2014 NCERC at ... will present his findings on corn stover pretreatment ... this week in Washington, D.C. , “Arun’s ... conference is a testament to the success of ... said. “Thanks to the foresight and vision of ...
(Date:7/30/2014)... 30, 2014 Adding to their already ... boat special – Buy 2 of any Weighing ... will benefit lab technicians looking for durable and reliable ... ideal for multiple applications including weighing liquids, solid, or ... choices including diamond-shaped, hexagonal, square, aluminum weighing, and standard ...
(Date:7/29/2014)... 2014 SoundConnect , an ... is proud to announce the strategic additions of ... their Boston, Charleston and Atlanta offices. SoundConnect’s ... demand for hosted solutions, collaboration and mobility that ... cost. , SoundConnect was founded in 2004, with ...
Breaking Biology Technology:Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2SoundConnect Organization and Culture is Evolving 2
... plugs, cut the cords, and can the cables as we ... for all the freedom and mobility, we are nowhere without ... the like. That fact alone has turned the average business ... most obscure corner of airports and coffee houses. Indeed, Im ...
... Motorists driving along the DeNeveu Creek bridge on Highway 151 ... they drive over a bridge that uses a new method ... concern themselves with the cost of road construction may definitely ... road. , ,Instead of having a roadbed reinforced with a ...
... When it comes to consumer goods, America is addicted to ... to low prices, Wal-Mart is the biggest low-price outlet going. ... to get it. , ,The company that many Americans hate ... and activist groups have successfully derailed its growth plans in ...
Cached Biology Technology:Power for the people 2UW-Madison engineers apply award-winning technology to road building 2Wal-Mart: How low can you go? 2Wal-Mart: How low can you go? 3Wal-Mart: How low can you go? 4
See product name for description....
Whole blood is collected from healthy pigs (mixed breed, either sex) at the time of slaughter, refrigerated within 6 hours, processed within 24 hours and frozen at -20ºC....
... DNA-binding protein(DBP). Protein size: ... NP_001343 ELISA titre using peptide based ... for Western Blot: 1.0g/ml in ... HRP conjugated anti-Rabbit IgG should be diluted ...
...
Biology Products: