Navigation Links
Molecular models advance the fight against malaria

Research from Dartmouth Medical School, demonstrating how malaria parasites form mutations that make them stubbornly resistant to drug therapy, may hold the key to a new treatments for a disease that afflicts more than half a billion people worldwide.

The scientists developed disease models using yeast and successfully introduced five mutations that make malaria resistant to the anti-malarial drug, atovaquone. The study, featured as the cover story of the April 29 Journal of Biological Chemistry, paves the way for using these models to test new drugs that could suppress malaria's ability to mutate against current therapy. "This is the first quantitative explanation for malaria's drug resistance," said Dr. Bernard Trumpower, professor of biochemistry at Dartmouth Medical School and head of the study. "In addition to confirming the belief that the resistance was due to these mutations, we have created a practical research tool to design new, improved versions of the drug using these resistant strains."

Malaria, transmitted by Plasmodium falciparum, a parasite carried by mosquitoes, has developed resistance to almost every anti-malarial drug introduced in the past 30 years. Although atovaquone is one of the most recent drugs on the market, there is significant evidence that malaria parasites are quickly developing resistance to that drug as well. According to WHO estimates, 40% of the world's population are currently at risk of the disease and approximately 2 million people, mostly children, are killed by malaria annually worldwide. Today marks Africa Malaria Day, organized to promote awareness of the disease in a country where a child is killed every 30 seconds by malaria.

Investigating ways to counter the mutations and sustain the efficacy of anti-malarial drugs, Trumpower and his colleagues continued their work on previous studies using yeast enzymes to explore atovaquone resistance. It is not possible to grow enough malaria parasites to isola
'"/>

Source:Dartmouth Medical School


Page: 1 2

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Molecular machine may lead to new drugs to combat human diseases
3. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
4. Molecular fossils uncover link between viruses and the immune system
5. Molecular thermometers on skin cells detect heat and camphor
6. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
7. Molecular steps involved in the creation of gene-silencing microRNAs identified
8. Molecular miners find pain relief drugs from the sea
9. Molecular mechanism of feather formation found
10. Molecular trigger for Huntingtons disease found
11. Molecular Partners Required For Appropriate Neuronal Gene Repression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular models advance the fight against malaria

(Date:6/30/2015)... June 30, 2015 To bolster its efforts and ... Corp. announced today the addition of two new team members. ... board advisor and David Raviv will act as ... HYPR Corp.,s commitment to providing the most secure solutions for ... co-founded Layer 7 Technologies, a provider of security and ...
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/25/2015)... -- TAKE Solutions Ltd., a global business technology solutions provider, ... and Trademark Office (USPTO) for its "Method for Optimizing ... Accelerators to reduce the time taken to standardize trial ... the accelerators), thus reducing time to market. ... heart of the patented Clinical Data Standardization Process are ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2TAKE Solutions Awarded Patent By USPTO 2
... of Medicine (BCM) are hoping a new gene therapy that ... will prove effective in preventing recurrence of the disease. , ... the safety of the treatment and determine the proper dosage ... BCM. It will be carried out in the department of ...
... Planck Institute of Colloids and Interfaces have presented a ... of microcapsules using the salt content and the temperature ... researchers developed a theoretical model which exactly describes the ... This means that is possible to predict, without any ...
... The increasing violence of storms under global climate change will ... for their future management. , A scientific team from the ... James Cook University has produced the world's first engineering model ... suffer when confronted with might of an angry sea. ...
Cached Biology News:Gene therapy study takes aim at prostate cancer 2Gene therapy study takes aim at prostate cancer 3Microcapsules like it hot and salty 2Microcapsules like it hot and salty 3Stormy days ahead for coral reefs 2Stormy days ahead for coral reefs 3
(Date:7/1/2015)... Calif. , July 1, 2015   ... on the development of groundbreaking drugs to treat ... announced today that Robert G. Miller , ... at Sutter Health,s California Pacific Medical Center in San ... ALS Association for $1.5 million to help fund ...
(Date:7/1/2015)... ... 2015 , ... A newly launched business plan contest will ask startup companies ... in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see small ... period of expert mentorship from a senior industry figure drawn from the Pistoia Alliance ...
(Date:7/1/2015)... ... July 01, 2015 , ... NEMA 4 (IP66) Medical ... new Medical Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. ... that will increase healthcare worker safety and reduce financial costs. , CTI Electronics ...
(Date:6/30/2015)... ... June 30, 2015 , ... Students ... part in the first half of “Integrative Biotechnology,” an applied biotechnology course team-taught ... summer 2014, this course combines students from both universities and is taught on ...
Breaking Biology Technology:Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2
... Stevens Point, Wis . - Representatives of Sentry Insurance ... a new office that will open in the Fox Valley ... expand its information technology operations in the valley, citing a ... U.S. Highway 10, which connects the central Wisconsin city to ...
... Madison, Wis. - The nation's space agency announced this month ... long enough to pack for the longer trip to Mars ... should bypass the Earth's lifeless satellite and head directly ... Still others say the government should get out of the business ...
... Madison, Wis. - The blood-brain barrier is a big problem ... at the University of Wisconsin-Madison believe they have found ... , ,The findings are the result of a collaborative study funded ... and ,led by UW-Madison professor of chemical and biological engineering ...
Cached Biology Technology:Flying to the moon? Take Wisconsin tech along 2Flying to the moon? Take Wisconsin tech along 3Flying to the moon? Take Wisconsin tech along 4Stem cells may provide answer to blood-brain barrier 2
... antigen initiates replication from the ... the presence of the host ... be used in conjunction with ... cat. no. 8050. For ...
Raised to 5-HIAA coupled to BSA with paraformaldehyde....
Request Info...
NuCycl DAPI Kit Application: Flow Cytometry Reactivity: Human...
Biology Products: