Navigation Links
Molecular Partners Required For Appropriate Neuronal Gene Repression

Oregon Health & Science University researchers have identified some of the key factors that prevent the repair of brain damage caused by multiple sclerosis (MS), complications of premature birth, and other diseases and conditions. The findings offer important clues about why the nervous system fails to repair itself and suggest ways that at least some forms of brain damage could be reversed. The research is published in the August edition of the scientific journal Nature Medicine.

"For many years, scientists have understood that damage to the insulation-like sheath surrounding nerve cells in the brain, called myelin, is part of the disease process for MS and other brain disorders," said Larry Sherman, Ph.D., an associate scientist in the Division of Neuroscience at the Oregon National Primate Research Center and an adjunct associate professor of cell and developmental biology in the OHSU School of Medicine. "In recent years, it became clear that there were cells at the sites of this damage that should have the capacity to repair the brain and spinal cord but they fail to do so. Our studies have revealed that there is a particular signal in the damaged brain that prevents these cells from restoring lost myelin. We're hopeful that we can develop methods to counteract this process in animal models in our search for human treatments."

Other key OHSU researchers involved in the study are: Stephen Back, M.D., Ph.D., an associate professor of pediatrics and neurology in the OHSU School of Medicine; and Bruce Bebo Jr., Ph.D., a scientist in the OHSU Neurological Sciences Institute and an associate professor of neurology in the OHSU School of Medicine.

The researchers decided to collaborate following a key finding in Sherman's lab where scientists were studying a mouse model for tumors in the central nervous system. The mice had been bred to overproduce a protein which had been implicated previously in tumor formation. The protein, called CD44, is
'"/>

Source:


Page: 1 2 3 4

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Molecular machine may lead to new drugs to combat human diseases
3. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
4. Molecular models advance the fight against malaria
5. Molecular fossils uncover link between viruses and the immune system
6. Molecular thermometers on skin cells detect heat and camphor
7. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
8. Molecular steps involved in the creation of gene-silencing microRNAs identified
9. Molecular miners find pain relief drugs from the sea
10. Molecular mechanism of feather formation found
11. Molecular trigger for Huntingtons disease found
Post Your Comments:
(Date:7/20/2015)... 2015  Acuity Market Intelligence,s latest research "The ... Commerce and Privacy" forecasts that between 2014 and ... be downloaded to smart mobile devices by 2.2 ... is projected to generate more than $67.9 billion ... forecast period.    "Biometrics is at ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
(Date:7/8/2015)... -- The consumer products industry for innovative tech ... such as wearables, smart wallets & other smart technology are ... continues to rapidly grow.  Biometrics & Wearable Device Companies in ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ... GPRO ) and Baidu Inc. (NASDAQ: BIDU ) ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... Louis, MO, October 26, 2010 In an insightful ... of the American Dietetic Association , Linda Van Horn, ... Dietary Guidelines Advisory Committee, and Professor and Associate Dean, ... features and noteworthy findings of the 2010 US Dietary ...
... Institute of Food and Agriculture (NIFA) awarded a $1.5 ... establish guidelines for increasing environmental, social, and economic sustainability ... Stewart of the U of I Department of Crop ... other ornamental crop production systems is waste generation due ...
... at the Institute of Vertebrate Paleontology and Paleoanthropology in ... in St. Louis, has discovered well-dated human fossils in ... emergence of modern humans in the eastern Old World. ... the online early edition of the Proceedings of ...
Cached Biology News:DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic 2DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic 3U of I receives $1.5 million to further sustainability in ornamental crop production 2U of I receives $1.5 million to further sustainability in ornamental crop production 3
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ... announces increased partnerships with VA and Military Medical ... Nerve Fiber Density (ENFD) and Sweat Gland Nerve ... fiber neuropathy ( https://therapath.com/skin ). ... Fiber Density (ENFD) on punch skin biopsy is ...
(Date:7/29/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... announce that the final design specifications of its ... for industrial and regulatory testing will now be ... mark clearance to market the injector in ... (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  The RCI-02 ...
(Date:7/29/2015)... FRANCE (PRWEB) , ... July 29, 2015 , ... ... Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel, a nighttime-specific product that ... the amount of sugars that are able to enter fat cells, inhibiting the ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard ... Yet few people realize that a rich source of these cells is teeth—baby teeth ... teeth that need to be pulled to make room for braces. These potent ...
Breaking Biology Technology:Neuropathology services for VA and Military health systems 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2
... Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced ... antisense inhibition of novel targets that could offer new ... Cancer Research (AACR) meeting. Research conducted by Isis ... large non-coding RNA, sigma RNA also known as Malat-1, ...
... April 20 Shire plc (LSE: SHP,NASDAQ: SHPGY ), the global ... , , Results press release will be issued at: ... Investor conference call time: ... EDT, , Live conference call for investors: , ...
... NORWOOD, Mass. April 20 Advanced ... 2020-BIO Multi-Sample Osmometer as the first true automation-friendly ... 2020-BIO Multi-Sample Osmometer is specifically designed ... for osmolality testing in the biopharmaceutical laboratory," said ...
Cached Biology Technology:Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 2Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 3Shire plc: First Quarter 2009 Results Date Notification - April 30, 2009 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 3
... C 4 H 10 O ... 154.25 PRODUCT SPECIFICATIONS Form: White crystalline ... to 97% Identity: By IR Melting ... 38C Oxidized DTT: less than or ...
... Feature Extraction Software reads and ... to prepare microarray data for ... * one 2-year license ... NFP/Academic accounts , * ...
... imported for data analysis , Automatic grid, subgrid ... template assignment , ... Extensive background and signal options to optimize, ... results , ...
... Stain combo offers these benefits: ... Offers a safer and ... Eliminates risks to yourself, the environment and your ... bp to >30 kb. UltraPure Agarose is a standard ...
Biology Products: