Navigation Links
Modified collagen could yield important medical applications

se molecules to collagen, you don't have to cook it or use harsh chemicals. You just mix them together in a solution."

In lab experiments, Yu and his colleagues have shown that this kind of molecular marriage does take place. They attached fluorescent tags to the peptides and observed the glow in collagen that had been mixed with the smaller molecules. Exactly how and why the collagen and the peptides join is uncertain. But researchers know that collagen molecules form a distinctive triple-helix in which three long protein strands intertwine like rope. Yu speculates that because the smaller collagen mimetic peptides have a propensity to make similar triple-helix structures, they are naturally attracted to collagen molecules. He believes the peptides make themselves at home within gaps formed by loose collagen strands.

This linkup opens the door to new medical treatments, Yu says, because it is easy to attach bioactive agents to the peptides. When the peptides bind with collagen, these attached agents can dramatically change the way collagen behaves in the body. For example, collagen normally attracts cells to close up a wound and form scar tissue. But this property is not always desirable; a clot can be dangerous inside a blood vessel or at certain injury sites, where scar tissue can interfere with the formation of new nerve connections.

Modified collagen can follow a different course. In their recent journal paper, Yu and his colleagues reported that they had attached a chemical, polyethylene glycol, to the peptides, causing collagen to repel cells instead of attracting them. When the researchers added human cells to a lab dish, the cells migrated toward an untreated collagen film but avoided the modified collagen sample. This form of collagen could stop the formation of blood clots and scar tissue, and scientists may be able to use it to control the shape and organization of cells and tissue that are grown in a lab, Yu says.

Still o
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
2. Wisconsin scientists find a way to make human collagen in the lab
3. Protein discovery could unlock the secret to better TB treatment
4. Tiny particles could solve billion-dollar problem
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
7. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
8. How the environment could be damaging mens reproductive health
9. Dead zone area in Gulf could be increasing, researchers say
10. Growth in biomass could put US on road to energy independence
11. Nano-bumps could help repair clogged blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Modified collagen could yield important medical applications

(Date:4/23/2014)... of Toronto Scarborough research shows that male black widow ... a rare example of mate preference by male ... post-doc Emily MacLeod and Maydianne Andrade, a professor in ... field studies and the wild that males overwhelmingly chose ... male black widows can tell whether a potential mate ...
(Date:4/23/2014)... Putnam Valley, NY. (Apr. 23, 2014) People who ... little potential to restore neurological function. However, a study ... future issue of Cell Transplantation , but is ... at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1168Chen , has found that when one ... stem cells (PBSCs) injected directly into the brain and ...
(Date:4/23/2014)... boom has transformed the energy landscape in the ... cause conflict among the energy industry, residents and ... They add that degraded water quality is a ... feature article appears in the ACS journal ... Mauter and colleagues point out that a major ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Autologous stem cell therapy improves motor function in chronic stroke victims 2How to avoid water wars between 'fracking' industry and residents 2
... scientist Dr. Gadi V.P. Reddy is concerned about ... health of island residents and ecosystems. He has ... use and has recently been awarded an $188,000 ... (USDA-NIFA) Pest Management Alternatives Program (PMAP). Dr. Monte ...
... PA, June 24, 2011 Adolescents who diet and ... behaviors and binge eating) carry these unhealthy practices into ... by University of Minnesota researchers and published in the ... American Dietetic Association . "The findings from the ...
... applications in reconstructive and cosmetic surgery and in the food ... prolines within the protein need to be hydroxylated. BioMed Central,s ... the first time the α1 chain of type 1 collagen ... hydroxylation to human collagen. Most collagen used is derived ...
Cached Biology News:UOG scientist wins USDA competitive funding 2Adolescents' dieting and disordered eating behaviors continue into young adulthood 2Adolescents' dieting and disordered eating behaviors continue into young adulthood 3
(Date:1/15/2014)... January 15, 2014 Cynvenio, a cancer ... through the genomic analysis of tumor cells in the ... a web-based cancer decision support application powered by CollabRx, ... Cynvenio’s ClearID™ genomic test, Therapy Finder will provide breast ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... widely used as a navigational tool in vehicles from ... vehicle on three axes to evaluate its exact position ... School of Physical Engineering is now scaling down this ... and more futuristic technologies. Working in collaboration with ...
... 5 Regenicin™, Inc. (OTC Bulletin Board: ... announced today that Mr. Christopher A. Hadsall, whose primary ... to join the company as Chief Operating Officer.  Mr. ... Regenicin™ and will be instrumental in working with various ...
... MiMedx Group, Inc. (OTC Bulletin Board: ... patent protected biomaterial-based products, announced today that its results ... be released before the opening of the market on ... live broadcast of its third quarter conference call on ...
Cached Biology Technology:A tracking device that fits on the head of a pin 2Regenicin Names Former U.S. Marine Corp Operations Officer, Christopher Hadsall, Chief Operating Officer 2Regenicin Names Former U.S. Marine Corp Operations Officer, Christopher Hadsall, Chief Operating Officer 3MiMedx Group, Inc. Announces Release Date For Third Quarter Results 2
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: