Navigation Links
Modification of program enables prediction of gene transcription

the UTR splice sites or incorrectly incorporate them into some protein-coding segment, making gene prediction a none-too-sure industry.

"We've found that when we add the spliced untranslated regions to our system, we not only get good predictions for UTRs but also improved predictions of the protein-coding region of the gene. By correctly identifying UTRs, we can avoid labeling them incorrectly as part of the protein-coding region," said Brent, who, with various colleagues, developed both TWINSCAN and N-SCAN. "It's important to know these two areas. Some of the signals that regulate transcription reside right near the transcription site. There is a huge amount of biology to be discovered there, and the appreciation of this area is growing daily."

While genomics researchers 15 years ago paid little attention to parts of the genome outside the coding regions, they have discovered some strange functions in UTR that have provoked second and third thoughts.

For instance, it recently was discovered that huntingtin, a gene associated with Huntington's disease, has a second protein segment encoded upstream of the main one. This protein in the so-called untranslated region is involved in regulating the gene. Running the modified TWINSCAN, on both the human and fruit fly genomes, Brent and colleagues predicted about 25,000 transcription-start sites, compared with a known 6,000.

"In the human genome, we found many extra exons on genes that were already known, or in some cases, spliced UTRs on genes that weren't even known to exist before," Brent said.

The system takes advantage of the scarcity of the CG sequence, finding so-called CpG "islands" known to be more common near the transcription-start site. It also has a knack for recognizing sequences that indicate splice sites. Over the past two years, TWINSCAN has been finding and predicting genes in numerous genomes that other gene prediction systems have missed. The addition of N-SCAN to
'"/>

Source:Washington University in St. Louis


Page: 1 2 3

Related biology news :

1. Modifications render carbon nanotubes nontoxic
2. Critical role in programmed cell death identified
3. Harmful chemicals may reprogram gene response to estrogen
4. Stem cell training program to make its Stanford debut
5. Rutgers to lead $52.7 million protein research program
6. DOEs Office of Science sets up program to aid scientists displaced by Hurricane Katrina
7. Costly breeding programs for endangered species pay off
8. HIV-infected adults in Botswana respond positively to ARV therapy public treatment program
9. Canine cancer vaccine program shows early promise
10. Its not fair! We are programmed to resist weight loss
11. Researchers unveil strategy for creating actively-programmed anti-cancer molecules
Post Your Comments:
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal ... that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four ... has served as a meeting place for peoples ... and the ongoing mixing of peoples with African, European, ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ... technology is accurate, flexible and robust – with the ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... GOCE satellite from the Plesetsk cosmodrome in northern Russia had ... due to an anomaly identified in one of the units ... stage (Breeze KM ). The correction of the problem ... perform this operation, it will be necessary to de-mate the ...
... physician-geneticist and leader of the Human Genome Project, has ... the Inamori International Center for Ethics and Excellence at ... and Kyoto Prizes for science, technology, philosophy and the ... ethical leaders. It is presented annually to an individual ...
... de los Alimentos (Institute of Nutrition and Food Technology) ... doing research into the positive effects of Mediterranean diet,s ... is a new research line about pancreatic cancer cells. ... points out that in the study ,Influence of the ...
Cached Biology News:Leader of Human Genome Project honored with the Inamori Ethics Prize 2New studies on the Mediterranean diet confirm its effectiveness for chronic disease prevention 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Maryland, July 1 Human Genome Sciences, Inc. (Nasdaq: ... top-line results available on Monday, July 20, from BLISS-52, the ... (belimumab, formerly LymphoStat-B(R)) in systemic lupus erythematosus (SLE). ... ) , , Senior management will host a ...
... DUSSELDORF, Germany, July 1 Gerresheimer AG, a,leading ... life,science industry, has sold its Technical Plastics operations, which are ... Group, Bad Soden,Germany. "Through the sale of the Technical Plastics ... step in its focus on the core,business of pharma & ...
... modified chlorophyll from an alga so that it resembles the ... able to determine the structure of these light antennae. This ... an artificial leaf. The researchers will be publishing an article ... the PNAS journal in the week starting 29 ...
Cached Biology Technology:Human Genome Sciences to Host July 20 Conference Call to Discuss Top-Line Phase 3 Results for Benlysta(TM) (Formerly Lymphostat-B(R)) in Systemic Lupus Erythematosus 2Gerresheimer Sells Technical Plastics Business 2First step to converting solar energy using 'artificial leaf' 2
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: