Navigation Links
Model identifies genes that induce normal skin cells to become abnormal

were removed and the matrix was left intact.

Then, normal human skin cells were seeded onto the melanoma-preconditioned matrix and were allowed to remain for several days.

After this period, the previously normal cells seeded onto the matrix preconditioned by the metastatic melanoma were reprogrammed to express genes (produce specific gene proteins) associated with a highly plastic cell type similar to the aggressive melanoma cells used in the study.

Removal of the "transdifferentiated" skin cells from the melanoma microenvironment caused the cells to revert to their original appearance.

"There were no significant genetic changes between normal skin cells grown on an untreated matrix and those exposed to a matrix preconditioned by human metastatic melanoma cells, further supporting the hypothesis that "epigenetic" induction of changes in skin cell gene expression is directly related to exposure to the metastatic microenvironment," the authors said.

Hendrix's co-researchers on the study were Elizabeth A. Seftor; Kevin M. Brown; Lynda Chin; Dawn A. Kirshmann; William W. Wheaton; Alexei Protopopov; Bin Feng; Yoganand Balagurunathan; Jeffrey M. Trent; Brian J. Nickoloff; and Richard E. B. Seftor, from Northwestern University; Harvard Medical School; Tgen; and Loyola University.


'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Study Models Impact Of Anthrax Vaccine
2. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
3. Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect
4. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
5. New lab technique identifies high levels of pathogens in therapy pool
6. Study identifies gene in mice that may control risk-taking behavior in humans
7. Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases
8. U. of Colorado researcher identifies tracks of swimming dinosaur in Wyoming
9. New study identifies key gene in development of connections between brain and spinal cord
10. New HIV study identifies high-risk subgroups of adolescents
11. Research identifies protein in mice that regulates bone formation
Post Your Comments:
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... Texas A&M University is one of 10 international ... scientific paper, "The Impact of Conservation on the Status ... published in Science, the academic journal of the American ... E. Lacher, Jr., Texas A&M University,s wildlife and fisheries ...
... United Kingdom,s National Oceanography Centre has been awarded a major ... to map complex habitats in the deep ocean and study ... ,Starting Grant, scheme aims to fund young, early career scientists ... are highly competitive, and this is the first ever such ...
... release is available in French . ... glucosamine causes the death of pancreatic cells and could increase ... researchers at Universit Laval,s Faculty of Pharmacy. Details of this ... Journal of Endocrinology . In vitro tests conducted by ...
Cached Biology News:Texas A&M University becomes key player in global study to save Earth's endangered species 2Glucosamine causes the death of pancreatic cells 2
(Date:5/4/2015)... Marianjoy Rehabilitation Hospital ... and hand impairments by acquiring the Armeo®Spring arm ... network site. , Secured through grant support of ... treatment option for patients with upper extremity weakness ... one of just four Illinois providers offering treatment ...
(Date:5/1/2015)... leading North American IT solutions and managed services provider, announced ... Partner Summit Country awards. Cisco named Softchoice ... the Year for Canada during its ... Montreal . "We are thrilled to ... year,s conference," said David MacDonald , Softchoice,s President and ...
(Date:5/1/2015)... TRIANGLE PARK, N.C. , May 1, 2015  United ... Roger Jeffs , Ph.D., President and Co-Chief Executive Officer of ... company,s business at the Deutsche Bank 40 th Annual ... The presentation will take place on Wednesday, May ... accessed via a live webcast on the United Therapeutics website ...
(Date:4/30/2015)... 30, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... that it has commenced an underwritten public offering of ... the underwriters a 30-day option to purchase up to ... stock offered in the public offering. The offering is ... assurance as to whether or when the offering may ...
Breaking Biology Technology:Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2Softchoice recognized with two Country Awards at Cisco Partner Summit 2015 2BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3
... ... intelligence and strategic planning for the medical device and biotechnology industry, today announced the ... promotion and implementation of The RC Insight Group. , ... (PRWEB) December 23, 2009 -- The RC ...
... scientists have developed tiny glitter-sized photovoltaic cells that could ... The tiny cells could turn a person into ... to flexible substrates molded around unusual shapes, such as ... hold the potential for a variety of new applications. ...
... cells is vital for our bodies to function. Part ... called neurotransmitters. The vesicle fuses with the nerve cell ... the next nerve cell. It is crucial that new ... continuously to take place. If parts of this communication ...
Cached Biology Technology:Lori Kahler Appointed President of The RC Insight Group 2Glitter-sized solar photovoltaics produce competitive results 2Glitter-sized solar photovoltaics produce competitive results 3Glitter-sized solar photovoltaics produce competitive results 4New insight in nerve cell communication 2
Mouse monoclonal antibody to FMN2 - formin 2...
Mouse polyclonal antibody to ALS2CR8 - amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8...
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531...
Determin interaction of your protein with Echelons lipids...
Biology Products: