Navigation Links
Model identifies genes that induce normal skin cells to become abnormal

were removed and the matrix was left intact.

Then, normal human skin cells were seeded onto the melanoma-preconditioned matrix and were allowed to remain for several days.

After this period, the previously normal cells seeded onto the matrix preconditioned by the metastatic melanoma were reprogrammed to express genes (produce specific gene proteins) associated with a highly plastic cell type similar to the aggressive melanoma cells used in the study.

Removal of the "transdifferentiated" skin cells from the melanoma microenvironment caused the cells to revert to their original appearance.

"There were no significant genetic changes between normal skin cells grown on an untreated matrix and those exposed to a matrix preconditioned by human metastatic melanoma cells, further supporting the hypothesis that "epigenetic" induction of changes in skin cell gene expression is directly related to exposure to the metastatic microenvironment," the authors said.

Hendrix's co-researchers on the study were Elizabeth A. Seftor; Kevin M. Brown; Lynda Chin; Dawn A. Kirshmann; William W. Wheaton; Alexei Protopopov; Bin Feng; Yoganand Balagurunathan; Jeffrey M. Trent; Brian J. Nickoloff; and Richard E. B. Seftor, from Northwestern University; Harvard Medical School; Tgen; and Loyola University.


'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Study Models Impact Of Anthrax Vaccine
2. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
3. Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect
4. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
5. New lab technique identifies high levels of pathogens in therapy pool
6. Study identifies gene in mice that may control risk-taking behavior in humans
7. Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases
8. U. of Colorado researcher identifies tracks of swimming dinosaur in Wyoming
9. New study identifies key gene in development of connections between brain and spinal cord
10. New HIV study identifies high-risk subgroups of adolescents
11. Research identifies protein in mice that regulates bone formation

Post Your Comments:
(Date:11/26/2009)...ed out in eight European countries has shown that ...ase pandemic could have a significant role in redu...the open access journal BMC Infectious Diseases ...s and weekends/holidays, finding that they were re...asselt and Antwerp University, Belgium, led a team...
(Date:11/26/2009)..., 27 November 2009 What are the bare essentials o...produce a cell that can survive on its own? Can we...erstand how an entire organism functions as a syst...ntists in a partnership between the European Molec...any, and the Centre de Regulacio Genmica (CRG) in ...
(Date:11/25/2009)...f.Scientists at the California Institute of Techno...ive emotion-like behavior in the fruit fly, Droso... be relevant to the relationship between the neuro...tivity disorder (ADHD), are described in the Decem...hila brain contains only about 20,000 neurons and...
Breaking Biology News(10 mins):School closure could reduce swine flu transmission by 21 percent 2First-ever blueprint of a minimal cell is more complex than expected 2First-ever blueprint of a minimal cell is more complex than expected 3Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 2Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 3Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 4A new take on growth factor signaling in tamoxifen resistance 49843 1A new take on growth factor signaling in tamoxifen resistance 49843 2Hanger Orthopedic Group Inc Announces Second Quarter 2009 Earnings Release Conference Call 49840 1Pelosi 3A We Are Leading the Way in Creating a Healthier America by Strengthening Health Care for Our Veterans 49837 1
...out the challenge of global food security featurin...he topic is such that the term "food security" has...hallenging context, Springer is launching the scie...ogy and Economics of Food Production and Access to...9 ( http://www.springer.com/life+sci/agriculture/j...
...ck the biological clock and extend their lifespan ...a biologists report. , Their study, published onl... , casts doubt on the old notion of a tradeoff bet... and scientific opinion have held that "the more y...aid senior author John Tower, associate professor ...
...we should be looking to the ground, not the sky, t...ilous impact on life on Earth. , Scientists at th... research findings in the prestigious journal, Na...y changes the molecular structure of organic matte...amount of carbon than does the atmosphere, yet, un...
Other Biology News:Springer launches Food Security 2Old flies can become young moms 2Global warming is changing organic matter in soil 2
(Date:11/25/2009)...FirstCall/--ArdeaBiosciences,Inc.(Nasdaq: RDEA )an...chiefexecutiveofficer,willpresentatthePiperJaffray...tailsareasfollows:,PiperJaffray21stAnnualHealthCa...p.m.EasternTime,Location:TheNewYorkPalaceHotel,New...t/ireye/,target=,_blank,title=,http://www.corpora...
(Date:11/24/2009)...r to also Visit Detroit , ...a, French Ambassador for International Investment,...cy, , , , ,What: Ambassador Appia is available to...itiatives adopted by France to further develop the...vation and development., , ,When: Available for In...
(Date:11/24/2009)...Nov.24/PRNewswire-FirstCall/--DowAgroSciencesCanad...,adivisionofThompsonsLimitedofBlenheim,Ontario.The...ces,currentseedsbusinessasthecompanyanticipatesthe...ciencesHerbicideTolerantTraitTechnologyincornin201...,, "Thisacquisitionbringstogethertwostrongprogr...
(Date:11/24/2009)...are employment grew by 29,000 jobs in October, an...t growth during the U.S. recession. However, clini...health systems are coming closer to having to actu...strators. , (Vocus) Novem...rowing in October despite the shedding of jobs in ...
Breaking Biology Technology:Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4
...ORANGE COUNTY, Calif., Oct. 20 Beckman,Coulter, I...f Directors,declared a quarterly dividend payout o... common stock, payable on November 17, 2008 to all...payout represents the 78th,consecutive, quarterly ...com/cgi-bin/prnh/20031202/BECLOGO ), Beckman Coul...
..., Leader in Diversity, Mi...ding joins Pierpoint International as Global VP of... San Jose, CA (PRWEB) October 20, 20...ce the appointment of Robert Cantu as Vice Preside...ntu, most recently served as AVP of Staffing and D...
...CAMBRIDGE, Mass., Oct. 20 Genstruct Inc., a syste...r mechanisms, networks and,biomarkers to better un...,it has appointed Julian Ray, Ph.D. as vice presid...be responsible for managing the continued evolutio...latforms and the company,s,IT functions., "Julian...
Other Biology Technology:Robert Cantu Appointed Vice President of Pierpoint International 2Genstruct Expands Team with New VP of Engineering 2Genstruct Expands Team with New VP of Engineering 3
HV Mini 3 (230V / 50Hz) from Thermo Scientific
Horizontal Plus 0.9 (230V / 50Hz) from Thermo Scientific
Horizontal Basis 1.2 (230V / 50Hz) from Thermo Scientific
...Incubated Orbital Shakers combine high durability ...ce and ease of use. The patented triple-counterbal...owing the unit to run at high speed with heavy, ou...rature range is delivered with tight uniformity by...
Biology Products: