Navigation Links
Missing Receptor Molecule Causes Tumor Growth

ng receptor and not the missing signal can contribute significantly to tumor growth.

Silenced Genes
Further tests proved why there was such a small number of receptors. Prof. Krainer: "There can be two reasons for the loss of a receptor molecule like DR4. Firstly, the responsible gene could have been lost or damaged. Secondly, this gene could have been modified in a way which would prevent it from functioning." It was exactly the latter. Prof. Krainer and his team ascertained that in 75% of the specimens which contained only a few DR4 receptors the responsible gene was modified. Some components of this gene were modified by attaching methyl groups. Methylation is indeed a common way in which cells silence genes, but in the affected tumor cells, it obviously happens at the wrong time.

To conclude their research, Prof. Krainer and his colleagues retested their findings: Their results were confirmed by testing 36 different tumor tissues taken directly from patients. In comparison, these cells represent the real causes of disease much better than cell cultures commonly used for experimental research. It was determined that in 20% of the tissues examined the gene responsible for DR4 was methylated to a higher degree and DR4 was missing.

This research supported by funding from the Austrian Science Fund, FWF, paves the way for future therapy through the important discovery that the methylation of the gene for DR4 can contribute to the formation of tumors. These therapies could manipulate the malfunctioning signal transfer system, DR4-TRAIL, to make cancer cells return to the originally programmed cell death.

Image and text will be available online from Wednesday, 15th June 2005, 09.00 a.m. MEZ onwards: http://www.fwf.ac.at/en/press/receptor.html


'"/>

Source:Medical University of Vienna


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. Missing fossil link Dallasaurus found
3. DNA Molecules Used To Assemble Nanoparticles
4. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
5. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
6. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
7. Touching Molecules With Your Bare Hands
8. Team Invents Device For Weighing Individual Molecules
9. Molecule by molecule, new assay shows real-time gene activity
10. Molecule does more than slice and dice RNA
11. Molecules in blood foretell development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Missing Receptor Molecule Causes Tumor Growth

(Date:8/4/2015)...  AMRI (NASDAQ: AMRI ) today reported financial and operating ... Highlights: , Second quarter contract revenue of $ ... , Adjusted contract margins of 26 % ... $0.05 decrease in EPS from royalties in the current quarter ... "We are very pleased to present another strong financial quarter, ...
(Date:7/31/2015)... de julho de 2015 A 10 a. ... será realizada pela BGI de 22-25 de outubro de 2015, ... A conferência está celebrando seu 10 o. aniversário ... se tornou uma das reuniões mais influentes do mundo ... mais dinâmicos, entusiastas e prazerosos. A ...
(Date:7/31/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT METHOD AND ... advance crypto-currencies such as Bitcoin into the consumer market ... to manage all payments.  The technology ...
Breaking Biology News(10 mins):AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... of data recorded during a record-setting expedition have yielded ... and thrive in the cold, dark, and highly pressurized ... unexplored ecosystems. Natalya Gallo of Scripps Institution of ... from the DEEPSEA CHALLENGE expedition, a project led by ...
... unlike conventionally leavened bread. Now Michael Gaenzle and colleagues ... sourdough production, bacteria convert the linoleic acid in bread ... The research, which could improve the taste of bread, ... Applied and Environmental Microbiology . The major ...
... D.C.Solar geoengineering is a proposed approach to reduce the ... deflecting some of the sun,s incoming radiation. This type ... uncertainties, however, including geopolitical questions about who would be ... New modeling work from Carnegie,s Katharine Ricke and ...
Cached Biology News:Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 2Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 3Why sourdough bread resists mold 2Geoengineering by coalition 2
(Date:8/28/2015)... , August 28, 2015 According ... (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by ... Medicine, Clinical Trials), End User - Global Forecast to ... expected to reach USD 3,731.03 Million by 2020 from ... of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... Wade McKenna, DO, announced today that the use of sterile, dehydrated amniotic tissue ... healing of an otherwise non-healing surgical knee wound. , The case involved a ...
(Date:8/27/2015)...  Neogen Corporation (NASDAQ: NEOG ) announced today ... United Kingdom -based Lab M Holdings, a developer, ... systems. Lab M was founded in ... microbial testing and diagnostic products for the global food, ... sells into more than 70 countries worldwide, and has ...
(Date:8/27/2015)... ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: ... three and six-month periods ended June 30, 2015. Biorem,s complete second ... www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ... , 2014 , 2015 , 2014 ... 9,398 , 4,433 Gross profit , 1,656 ...
Breaking Biology Technology:Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Neogen acquires U.K.-based Lab M Holdings 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3
... Switzerland and NUTLEY, N.J., Oct. 1 This ... leading business and,marketing publications, selected Roche out of ... Year." This marks the first time Roche has,received ... company,s focus on innovation-driven,healthcare as demonstrated by its ...
... Nedwin, Ph.D., MBA to Join Genencor,s Senior Management ... a division of Danisco,A/S, today announced that Dr. ... Vice President - Technical Enzymes, effective Oct. 1, ... Team, Dr. Nedwin will head the,division,s activities in ...
... - Guaranteed ... ... Products - Value Projected To Range ... Sheets: CARN) ( http://www.CarringtonLabs.com ),today announced it has formalized its previously announced multi-year,supply and ...
Cached Biology Technology:Med Ad News Honors Roche as 'Company of the Year' 2Med Ad News Honors Roche as 'Company of the Year' 3Genencor Appoints New Executive Vice President - Technical Enzymes 2Carrington and DaySpring Pharma Extend and Formalize Agreement for Distribution of Diabetic and Radiation Products Into Physician Market 2Carrington and DaySpring Pharma Extend and Formalize Agreement for Distribution of Diabetic and Radiation Products Into Physician Market 3
RABBIT ANTI GLYCINE...
... (CMV) pp65 Antigenemia Immunofluorescence Assay (IFA) is ... matrix protein pp65 of CMV in isolated ... Erythrocyte Lysis Buffer - ... mL of buffered ammonium chloride. (NH4CL) ...
... For use with suspension ... RiboCap™ uses vacuum filtration or ... culture media. Compatible with ... available in larger package sizes ...
... magnetic separator for 96-well microplates ... conjunction with the Captivate ferrofluid ... other magnetic particles and is ... Cell Biology Cell Separation Captivate ...
Biology Products: