Navigation Links
Missing Receptor Molecule Causes Tumor Growth

ng receptor and not the missing signal can contribute significantly to tumor growth.

Silenced Genes
Further tests proved why there was such a small number of receptors. Prof. Krainer: "There can be two reasons for the loss of a receptor molecule like DR4. Firstly, the responsible gene could have been lost or damaged. Secondly, this gene could have been modified in a way which would prevent it from functioning." It was exactly the latter. Prof. Krainer and his team ascertained that in 75% of the specimens which contained only a few DR4 receptors the responsible gene was modified. Some components of this gene were modified by attaching methyl groups. Methylation is indeed a common way in which cells silence genes, but in the affected tumor cells, it obviously happens at the wrong time.

To conclude their research, Prof. Krainer and his colleagues retested their findings: Their results were confirmed by testing 36 different tumor tissues taken directly from patients. In comparison, these cells represent the real causes of disease much better than cell cultures commonly used for experimental research. It was determined that in 20% of the tissues examined the gene responsible for DR4 was methylated to a higher degree and DR4 was missing.

This research supported by funding from the Austrian Science Fund, FWF, paves the way for future therapy through the important discovery that the methylation of the gene for DR4 can contribute to the formation of tumors. These therapies could manipulate the malfunctioning signal transfer system, DR4-TRAIL, to make cancer cells return to the originally programmed cell death.

Image and text will be available online from Wednesday, 15th June 2005, 09.00 a.m. MEZ onwards: http://www.fwf.ac.at/en/press/receptor.html


'"/>

Source:Medical University of Vienna


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. Missing fossil link Dallasaurus found
3. DNA Molecules Used To Assemble Nanoparticles
4. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
5. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
6. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
7. Touching Molecules With Your Bare Hands
8. Team Invents Device For Weighing Individual Molecules
9. Molecule by molecule, new assay shows real-time gene activity
10. Molecule does more than slice and dice RNA
11. Molecules in blood foretell development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Missing Receptor Molecule Causes Tumor Growth

(Date:8/29/2014)... Until recently, little has been known about what genetic ... team of scientists, one of whom is a University ... showing that genes controlling the development of the brain ... domestication., The study was published Aug. 28 in ... It is online at http://www.sciencemag.org/ ., The domestication ...
(Date:8/29/2014)... available in German . ... organisms is considered the oldest form of communication. Acting ... for example, the sexual attraction between males and females. ... to coordinate reproductive behavior in males and females. Scientists ... the Algarve in Faro, Portugal, and at the Max ...
(Date:8/28/2014)... Invasives is now available from the Lady Bird Johnson ... for identifying harmful non-native plant, insect and other invasive ... States cause about $137 billion in economic and other ... kill native plants and more. , "By having streamlined ... invasive species occur, we,re more likely to catch these ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Ready for mating at the right time 2Ready for mating at the right time 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... called nestin to a particularly deadly form of breast ... earlier detection and better treatment. , In the ... Medical School demonstrate that nestin could represent a selective ... aggressive cancer with similarities to mammary stem cells, the ...
... long term hip replacement surgery may lie in the genes, ... the Rheumatic Diseases. , The researchers analysed genetic variations in ... after hip replacement in the 10 years following surgery. ... ÔÇťaseptic loosening,?which describes a condition in which the artificial joint ...
... leopard found on the islands of Borneo and Sumatra is ... was originally thought to be the same species as the ... analysis conducted at the U.S. National Cancer Institute shows that ... to the differences between other large cat species like lions, ...
Cached Biology News:Selective marker found to indicate aggressive form of breast cancer 2New species declared: Clouded leopard on Borneo and Sumatra 2
(Date:8/31/2014)... Aug. 31, 2014 Wockhardt Limited today announces ... in Anti-Infective research when two of its drugs, WCK ... Disease Product (QIDP) status from U.S. Food & Drug ... act against pathogens which have a high degree of ... Centre for Disease Control (a top U.S. government health ...
(Date:8/31/2014)... 2014 Market Research Report ... and in-depth research report on the Polyacrylamide ... including Polyacrylamide definition, classification, application, and industry ... This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic ...
(Date:8/30/2014)... 2014 The Global and China ... in-depth study on the current state of the ... , The report provides a basic overview of ... structure. Global market analysis and Chinese domestic market ... developments, trends and competitive landscape of the market. ...
(Date:8/29/2014)... circuits are based on electrons, but one of the ... circuits, i.e. circuits based on light (photons) instead of ... create a stream of single photons and control their ... of attempts to achieve this control, but now scientists ... a steady stream of photons emitted one at a ...
Breaking Biology Technology:U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2
... 31 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,(Nasdaq: CHBT ... in the manufacture, research, development, marketing and,distribution of ... four patents to the State Intellectual Property Office ... These applications are patents for a ...
... Ueno, Ltd. announced on July 29 after discussing its R&D policy ... day and determined the R&D items as follows. , , ... ophthalmologic & dermatological fields that are its priority and exclusive areas, ... 1. Development code UF-021 (eye diseases) , , ...
... , , PHILADELPHIA, July 30 eResearchTechnology, Inc. (ERT), ... and other services to the biopharmaceutical, medical device and related industries, announced ... 2009. Unless otherwise noted, all comparative numbers refer to changes from ... , Highlights of the second quarter of 2009 were: ...
Cached Biology Technology:China-Biotics, Inc. Applies for Four Patents on Probiotic Formulations 2China-Biotics, Inc. Applies for Four Patents on Probiotic Formulations 3R-Tech Ueno Notifies R&D Items 2R-Tech Ueno Notifies R&D Items 3ERT Reports Second Quarter 2009 Results 2ERT Reports Second Quarter 2009 Results 3ERT Reports Second Quarter 2009 Results 4ERT Reports Second Quarter 2009 Results 5ERT Reports Second Quarter 2009 Results 6ERT Reports Second Quarter 2009 Results 7ERT Reports Second Quarter 2009 Results 8ERT Reports Second Quarter 2009 Results 9ERT Reports Second Quarter 2009 Results 10ERT Reports Second Quarter 2009 Results 11ERT Reports Second Quarter 2009 Results 12
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
Fibulin-2 (D-15)...
ABIN-2 Polyclonal Ab 100 ug rabbit polyclonal antibody. Detects ABIN-2 in human/mouse. Tested in WB....
Laminin beta-2 (C4)...
Biology Products: