Navigation Links
Minor mutations in avian flu virus increase chances of human infection

in turn contain terminal sialic acids. Avian viruses prefer binding to ?2-3-linked sialic acids on receptors of intestinal epithelial cells, while human viruses are usually specific for the ?2-6 linkage on epithelial cells of the lungs and upper respiratory tract. Such interactions allow the virus membrane to fuse with the membrane of the host cell so that viral genetic material can be transferred to the cell.

The switch from ?2-3 to ?2-6 receptor specificity is a critical step in the adaptation of avian viruses to a human host and appears to be one of the reasons why most avian influenza viruses, including current avian H5 strains, are not easily transmitted from human-to-human following avian-to-human infection. However, the report did suggest that "once a foothold in a new host species is made, the virus HA can optimize its specificity to the new host."

"Our recombinant approach to the structural analysis of the Viet04 virus showed that when we inserted HA mutations that had already been shown to shift receptor preference in H3 HAs to the human respiratory tract, the mutations increased receptor preference of the Viet04 HA towards specific human glycans that could serve as receptors on lung epithelial cells," Wilson said. "The effect of these mutations on the Viet04 HA increases the likelihood of binding to and infection of susceptible epithelial cells."

The study was careful to note that these results reveal only one possible route for virus adaptation. The study concluded that other, as yet "unidentified mutations" could emerge, allowing the avian virus to switch receptor specificity and make the jump to human-to-human transmission.

The glycan microarray technology, which was used to identify the mutations which could enable adaptation of H5N1 into the human population in the laboratory, could also be used to help identify new active virus strains in the field by monitoring changes in the receptor binding preference profile wh
'"/>

Source:Scripps Research Institute


Page: 1 2 3

Related biology news :

1. Minorities, uninsured less likely to receive care at high-volume hospitals
2. Novel technology detects human DNA mutations
3. Mitochondrial DNA mutations play significant role in prostate cancer
4. Bioelectronic ‘signatures?hold key to DNA mutations
5. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
6. DNA size a crucial factor in genetic mutations, study finds
7. New view of cancer: Epigenetic changes come before mutations
8. ASU researchers wire DNA to identify mutations
9. Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher
10. New findings offer more complete view of breast cancer gene mutations in US population
11. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Minor mutations avian flu virus increase chances human infection

(Date:7/21/2014)... a professor of entomology and cooperating faculty ... the University of California, Riverside, has been awarded the ... of Chemical Ecology ( ISCE ). , Awarded first ... the society,s highest honor. It is awarded annually to ... the study of chemicals that mediate interactions between living ...
(Date:7/21/2014)... high health risk warning for Yellowknife and surrounding area ... forest fires. Currently 160 wildfires are burning across ... since these fires are endangering people or property. ... with mixed results. The rains help to dampen ... , This year the Northern Territories have seen 855,000 ...
(Date:7/21/2014)... Diego School of Medicine-led study suggests that parents of ... health consequences of childhood weight gain or the importance ... a healthy weight. , The study is published online ... and Dietetics . , "Parents have a hard time ... lead author Kyung Rhee, MD, and an assistant adjunct ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Parents rank their obese children as 'very healthy' 2
... 9, 2007) -- When its time for moose to ... to where it is safest from predators namely ... the Wildlife Conservation Society. Published in the Royal ... avoid predation of their calves by grizzly bears by ...
... MIT Holding, Inc. (OTCBB: MITD), in collaboration with ... designs of the patent pending PROVECTOR. This small dispensable ... and parasites found in mosquitoes that carry deadly diseases ... The PROVECTOR will initially be made available in countries ...
... of the leading global STM publishers, has entered a ... the journal Estuaries and Coasts. Appearing six times ... promoting research on and management of estuarine and coastal ... be February 2008. The partnership will be officially ...
Cached Biology News:MIT Holding, Georgia Southern University, and MEVLABS successfully test the PROVECTOR 2Estuarine Research Federation chooses Springer as publishing partner 2
(Date:7/22/2014)... July 22, 2014 The DNA ... and concise visual representation of history, migration, and culture. ... always regaled by family history stories stemming from Europe. ... the "old country." Pictures and 8mm home movies painted ... of the family, and Steve ordered a test from ...
(Date:7/22/2014)... Corporation (NASDAQ: NEOG ) announced today that ... 31, increased 19% from the previous year to $247,405,000. ... prior year,s $27,190,000. Adjusted for a 3-for-2 stock split ... current year were $0.76, compared to $0.75 a year ... fiscal year established new all-time highs for the 32-year-old ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts en SHENZHEN, China ... Solutions Co., LTD, (BGI Tech), een dochtermaatschappij van BGI, ... kondigde de wereldwijde introductie aan van een nieuwe service ... de sector meest geavanceerde platform van Complete Genomics. ... bedrijf dat binnen de sector in hoog aanzien staat ...
(Date:7/22/2014)... In chemical and petrochemical plants, and ... The rapid rise of TDL analyzers over recent ... a core gas measurement technology, and their high ... gas analyzer technology of choice for many companies. ... processes have limited their application range. METTLER TOLEDO's ...
Breaking Biology Technology:DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4Neogen reports 19% increase in annual revenues 2Neogen reports 19% increase in annual revenues 3Neogen reports 19% increase in annual revenues 4Neogen reports 19% increase in annual revenues 5Neogen reports 19% increase in annual revenues 6Neogen reports 19% increase in annual revenues 7Neogen reports 19% increase in annual revenues 8BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2METTLER TOLEDO Shows How Tunable Diode Lasers (TDLs) Can Be Installed Where No TDLs Have Gone Before 2
... quarter has come and gone and daylight savings time is now ... market, on the other hand, is in the midst of a ... uniformly across the board. Only the Dow Jones Industrials fared better ... the song Stormy Monday came from). The Nasdaq shed blood in ...
... On Thursday afternoon undergraduates from 15 University of Wisconsin ... in Madison. , ," Posters in the Rotunda " ... with state and university officials and the public from ... short program will include remarks from UW System President ...
... & Electric has released its 2005 Greater Madison ... updated listings covering 394 organizations. , ,The directory, which ... an overview of the high-tech firms, professional organizations, venture ... Dane County, as well as an array of other ...
Cached Biology Technology:Midwest shares in stock-market bloodshed as biotechs falter 22005 Madison-area tech directory includes more companies, resources 22005 Madison-area tech directory includes more companies, resources 3
... Physical form: Solution in 50% glycerol containing 20 mM ... and 20 mM NaCl Preparation Unit Definition: One unit ... equivalent to a ΔA 260 of 1.0 in ... volume 2.625 ml). Assay: SDS-PAGE ≥ 90 % ...
Mouse monoclonal antibody to PPP2R2C - protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
... quantitation kit is used to quantitate double-stranded DNA ... RNA or protein. With this kit, DNA is ... detected with a VersaFluor or other fluorometer. The ... ng per ml to 5 micrograms per ml ...
Biology Products: