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Migration alert -- How tumor cells home in on the lymphatic system

ells can both produce and use the same signaling molecule, and it highlights the significance of the biophysical environment in the vicinity of a tumor, particularly the existence of continuous slow flow in the direction of functional lymphatics.

This research could open new avenues for combating metastasis, says Swartz. “It implies that if a lymphatic was blocked, tumor cells would be less attracted to it. This means that tumor cells “know” which lymphatic vessels will be more effective routes for dissemination,” she explains. “Therapeutically, it indicates that a drug target for lymph node metastases could be blocking the signaling molecule or its receptor on the tumor cell.”
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Source:Ecole Polytechnique Fédérale de Lausanne


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