Navigation Links
Migration alert -- How tumor cells home in on the lymphatic system

A Swiss-based research team has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therapies.

Scientists know that tumor cells spread via the lymphatic system, but they don’t understand the details of how this deadly migration takes place. In the June 2007 issue of the journal Cancer Cell, EPFL Professor Melody Swartz and postdoctoral researcher Jacqueline Shields provide an explanation along with data to support it.

Tumors produce excess fluid that continually percolates from the tumor towards nearby lymphatic vessels. The EPFL research shows how tumor cells use a clever chemical strategy to exploit this slow, one-way flow in order to migrate to functional lymphatic vessels.

As part of their intercellular drainage job, lymphatic tissues secrete small quantities of a signaling molecule. Cells migrate towards high concentrations of this molecule, so if they are close enough to the lymphatic to sense the molecule, they will migrate towards the vessel. Swartz’s group showed that tumor cells secrete this same molecule. Since lymphatics drain fluid, there will always be slow fluid flow going away from the tumor into the lymphatic vessel. This slow flow biases the concentration distribution of this molecule towards the lymphatic, and the tumor cell follows it, like the proverbial carrot on a stick. Near the vessel, concentrations of the signaling molecule are reinforced by the lymphatic’s own secretions, fine tuning the tumor cells’ migration and guaranteeing that they will home in on the lymphatic.

To demonstrate this new concept, the researchers engineered a tissue culture model of the tumor-lymphatic microenvironment and developed computational models to calculate the gradients of the signaling molecule.

The study provides the first evidence that tumor c
'"/>

Source:Ecole Polytechnique Fédérale de Lausanne


Page: 1 2

Related biology news :

1. Migration played key role in HIV spread in South Africa
2. New study finds how cells with damaged DNA alert the immune system
3. Mouse brain tumors mimic those in human genetic disorder
4. Researchers add new tool to tumor-treatment arsenal
5. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
6. Pulsating ultrasound enhances gene therapy for tumors
7. Scientists identify molecule that regulates well-known tumor suppressor
8. New tumor-suppressor gene discovered
9. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Unexpected lock and key mechanism found for the assembly of tumor blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Migration alert How tumor cells home the lymphatic system

(Date:7/14/2014)... protein, discovered in 2005, controls T-cell activation and ... In doing so, it helps to guarantee immunological ... own structures that can lead to autoimmune disease. ... affect between five and ten per cent of ... of complex environmental influences when a genetic predisposition ...
(Date:7/14/2014)... 140 years ago, Charles Darwin noticed something peculiar about ... are more tame, and they also tend to display ... patches of white fur, and more juvenile faces with ... pattern has proved elusive, but now, in a Perspectives ... new hypothesis has been proposed that could explain why ...
(Date:7/13/2014)... women suggests that experiencing one or more stressful events ... slow the body,s metabolism, potentially contributing to weight gain. ... stressors before giving them a meal consisting of 930 ... measured their metabolic rate how long it took ... took measures of blood sugar, triglycerides, insulin and the ...
Breaking Biology News(10 mins):Molecular mechanisms underlying the prevention of autoim-munity by Roquin revealed 2Domestication syndrome: White patches, baby faces and tameness 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4
... Florida State University marine biologist David L. Kimbro will ... in a massive effort to study the health and ... estuaries spanning 1,000 miles of Atlantic and Gulf of ... June 1, has become even more vital now following ...
... fluent in English whose first language is Chinese retrieve their ... in the June 2 issue of The Journal of ... second language in adolescence or later recall the sounds of ... study, Yan Jing Wu, PhD, and Guillaume Thierry, PhD, of ...
... release is available in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2010-06/sfeb-tio060110.php,">Chinese . ... of Medicine, in New Orleans, LA, have demonstrated ... seed oil ( Nigella sativa ) can suppress ... cell lines, in vitro. Although previous studies ...
Cached Biology News:Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 2Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 3Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 4Second language learners recall native language when reading 2Thymoquinone induced oxidative stress targets highly aggressive prostate cancers 2
(Date:7/14/2014)... 14, 2014 Throughout this past ... the clinical trials space, representing 38 countries globally, ... entitled “Optimizing Patient Participation in Clinical Trials. Attract. ... with internationally renowned R&D expert, Ken Getz, of ... Reinventing Drug Development through Patient Centricity. , Throughout ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... Role of Chairman of the Board - , , ... INSM ), a biopharmaceutical company, today announced that Geoffrey Allan, ... Chairman of the Board of Directors, effective immediately, due to ... President, Chief Executive Officer and Chairman of the Board since ...
... , , , PHILADELPHIA, June 15 ERT ... and eClinical technology, ePRO, and other services to the biopharmaceutical, medical ... its portfolio of products and services at Booth #507 at the ... , , ERT will be showcasing, for the first ...
... returns to Paris for 2010 when, with ICSE, PMEC and BioPh, the ... on Tuesday 5 - Thursday 7 October. This is a week earlier ... to the dates of the last staging in Paris ... the quartet of co-located events to rival the 25,000+ attendees expected this ...
Cached Biology Technology:Insmed CEO Resigns Due to Health Concerns 2Insmed CEO Resigns Due to Health Concerns 3ERT to Showcase Its Clinical Trials Portfolio at DIA's 45th Annual Meeting at Booth #507 2ERT to Showcase Its Clinical Trials Portfolio at DIA's 45th Annual Meeting at Booth #507 3Paris Dates for CPhI Worldwide 2010 2