Navigation Links
Microfluidic chip helps solve cellular mating puzzle

Using a biochemical version of a computer chip, a team led by Johns Hopkins researchers has solved a long-standing mystery related to the mating habits of yeast cells.

The findings, described in the Feb. 18 Advance Online Publication of the journal Nature, shed new light on the way cells send and receive signals from one another and from the environment through a process called signal transduction. That process, when impaired, can lead to cancer or other illnesses.

"Yeast is a very simple single-celled organism, but in many respects it operates much like a human cell," said Andre Levchenko, an assistant professor in the Department of Biomedical Engineering at Johns Hopkins and supervisor of the research team. "That’s why it’s been studied for many years -- because what we find out in yeast often holds true for humans as well. In this study, we looked at how yeast cells signal one another when they want to merge, engaging in a type of mating behavior. Human cells ‘talk?to one another in a similar way, and it’s important to understand this process."

Yeast cells mate by sending out pheromone designed to catch the attention of nearby cells of the opposite mating type. When a prospective partner picks up this "scent," it alters its shape and sends a projection toward the source of the pheromone, leading to a cellular merger. This mating process is regulated by proteins inside the cell called mitogen-activated protein kinases, or MAPKs, through a chain of chemical reactions.

First, sensors on the surface of a yeast cell pick up signals that a mating partner is nearby. Then the message is passed down toward the cell’s control center, the nucleus. The messengers that carry it to the nucleus are MAPKs, which direct the cell’s response by triggering multiple genes. But biologists have been baffled for years as to why two different forms of MAPKs perk up when the mating call arrives. Only one of them, called Fus3, appeared to be in charge
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences
2. Jumping gene helps explain immune systems abilities
3. Protein helps regulate the genes of embryonic stem cells
4. Scientists reveal the shape of a protein that helps retroviruses break into cells
5. Thai spice helps cut blood sugar swings
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Ancient DNA helps clarify the origins of two extinct New World horse species
8. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
9. Study: Well-known protein helps stem cells become secretory cells
10. Beyond genes: Lipid helps cell wall protein fold into proper shape
11. Simple sea sponge helps scientists understand tissue rejection
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Microfluidic chip helps solve cellular mating puzzle

(Date:8/5/2015)... , August 5, 2015 ... & Access Management Market by Software, Services, Vertical (BFSI, Airport, ... & Geography - Global Forecast to 2020", published by ... Management Market globally into various segments. The global PIAM ... 2014 to $546.2 Million by 2019, at a CAGR ...
(Date:8/4/2015)... , Aug. 04, 2015 ... ) has announced the addition of the ... Software, and Service), Sub-Segment (Computer Forensics, Network ... Tool Types, Service, Vertical and Region - ... their offering. By Component (Hardware, ...
(Date:7/31/2015)... Den 10. internationale konference om Genomik (ICG-10, ... - 25. oktober i Shenzhen , ... i år. Siden starten i 2006 er ICB blevet ... og er en af de mest dynamiske, entusiastiske og ... nylige gennembrud og fremskridt inden for ,omik,-forskning, som yderligere ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... July 6, 2011 Broadlawns Medical Center is ... part of Broadlawns, facilities modernization plan and commitment to be ... Center will be using palm scanners to register and check-in ... to the public today at Broadlawns Medical Center as part ...
... is not only associated with infertility but also with significantly ... of life equivalent to that of people with type 2 ... College, London, UK. Previous studies of POF, defined as ... assessed the small group of women who seek hospital care, ...
... the European IVF Monitoring group (EIM) on 2008 cycles and ... cycles highlighted were Sweden,s low rate of multiple births ... share of egg donations in Europe. The EIM collected ... time. Until today, egg freezing is still not offered on ...
Cached Biology News:Broadlawns Installs First-in-Iowa Biometric Patient Identity Security System 2Broadlawns Installs First-in-Iowa Biometric Patient Identity Security System 3Socioeconomic class and smoking linked to premature menopause 2For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs 2For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs 3
(Date:8/26/2015)... Aug. 26, 2015  The Diabetes Research Institute ... of Miami Miller School of Medicine, announced today ... to test for the first time a novel ... This FDA approved Phase I/II study builds upon ... is an important first step toward the development ...
(Date:8/26/2015)... 26, 2015 Intrexon Corporation (NYSE: XON ... closing of its previously announced public offering of common ... of their option to purchase an additional 731,707 shares ... $41.00 per share.  The exercise of the underwriters, option ... sold by Intrexon to 5,609,756 shares and increased the ...
(Date:8/26/2015)... 2015 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced that the Company has been informed that Magnum ... owned by Mr. Yuen Kam, chairman of the board ... shares (the "Shares") of  Excellent China Healthcare Investment Limited ...
(Date:8/26/2015)... August 26, 2015 Despite ... fueling the optimism in biotech,s forecast is the ... life sciences advancements.  Active biotechnology & healthcare companies ... Inc. (OTCQB: PBIO), Sequenom, Inc. (NASDAQ: SQNM ... Raptor Pharmaceutical Corp. (NASDAQ: RPTP ) and ...
Breaking Biology Technology:Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7
... Wis. - API Software, Inc. announced ... purchase multiple components of the company's API LaborWorkx product. ... installations in the United States, with customers ranging in ... , ,Hospitals recently purchasing API software include: , , ...
... of e-mail on vacation or the weekend? According to a ... on vacation. Most people check their email an average of 5 ... address and a quarter of the respondents, said they couldnt go ... air date: Saturday, July 9, 2005 , , Listen ...
... - The Proceedings of the National Academy ... the University of Wisconsin-Madison and Cold Spring ... disorder Huntington's disease. , ,The study, authored by researchers ... scientist Eric Drier, said that by elevating levels of ...
Cached Biology Technology:
Request Info...
... FLA-7000 excels at fluorescent and radioisotopic image ... features four easy-to-access filters (filters of Y520, ... Imaging Plates) for upgrading flexibility. In addition, ... four kinds of excitation laser beams. ,The ...
... Labeling Kit generates labeled cDNA for use ... is made via a reverse transcription from ... Unlike other methods, there are no unnatural ... reaction. This unmodified cDNA is then labeled ...
... An easy-to-use solution that enables fully automated ... 400 Hybridization Station has been designed to ... the throughput necessary to perform a wide ... performed in the range 485C; denaturations of ...
Biology Products: