Navigation Links
MicroRNAs as tumor suppressors

In the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro.

"Overexpression of HMGA2 is an important feature of many medically important tumors like uterine fibroids,?explains Dr. Dutta. “It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2, and so may have a role in the causation and perhaps the cure of a disease that is responsible for the vast majority of hysterectomies in the Western world."

Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3?end of the HMGA2 transcript, and prevent let-7 binding, result in aberrantly high levels of HMGA2 expression and tumorigenesis. This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells.
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. MicroRNAs play a big part in gene regulation - and evolution
2. MicroRNAs have shaped the evolution of the majority of mammalian genes
3. MicroRNAs can be tumor suppressors
4. Mouse brain tumors mimic those in human genetic disorder
5. Researchers add new tool to tumor-treatment arsenal
6. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
7. Pulsating ultrasound enhances gene therapy for tumors
8. Scientists identify molecule that regulates well-known tumor suppressor
9. New tumor-suppressor gene discovered
10. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
11. Natural tumor suppressor in body discovered by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MicroRNAs tumor suppressors

(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... have cloned a gene that controls the shape of tomatoes, ... huge morphological differences among edible fruits and vegetables, as well ... The gene, dubbed SUN, is only the second ever found ... various tomato varieties, said Esther van der Knaap, lead researcher ...
... at the request of the PIO. , Without a ripple ... though they lack flippers or fins. University of Utah biologists ... and rib muscles to shift their lungs like internal floatation ... when they surface and sideways when they roll. It ...
... the principle of "strength in numbers" more apparent than ... these one-cell organisms -- which number about 5 million ... on Earth -- affect virtually every ecological process, from ... oxygen. But even though microbes essentially rule the ...
Cached Biology News:Crop scientists discover gene that controls fruit shape 2Crop scientists discover gene that controls fruit shape 3Crop scientists discover gene that controls fruit shape 4How alligators rock and roll 2How alligators rock and roll 3How alligators rock and roll 4How alligators rock and roll 5New window opens on the secret life of microbes 2
(Date:12/17/2014)... December 17, 2014 This report ... Quartz Tubing industry. For an overview analysis, the ... application, industry chain structure, industry overview, policy analysis, ... tubing industry has witnessed rapid development with ... of acquisitions. This report mentions quartz tubing upstream ...
(Date:12/17/2014)... Audacity, a leading California-based health and science ... Huntsworth Health Group, is proud to announce the addition ... role, Gonzales will serve as Senior Vice President of ... welcome a talent of Jamie’s caliber to the Audacity ... is a proven healthcare innovation leader and brand management ...
(Date:12/17/2014)... CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary commercial focus on China , ... C meeting with the U.S. Food and Drug Administration ... February 2015.  During this meeting the Company will seek ...
(Date:12/15/2014)... (PRWEB) December 15, 2014 METTLER ... inline PVM tool, ParticleView V19 with PVM ... situ probe-based particle vision and measurement tool continuously ... process conditions. ParticleView V19 then automatically prepares a ... tracking particle size and concentration changes. This compelling ...
Breaking Biology Technology:2020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... ... ... (Nasdaq: PRXL ), a leading global biopharmaceutical services,organization, today ... Clinical Research Co., Ltd. ("APEX").,The acquisition strengthens PAREXEL,s global capabilities, ...
... SEATTLE, Sept. 26 Today at the ... introduction of a,ground-breaking vaccine to eliminate epidemic ... conjugate vaccine, developed by the Meningitis,Vaccine Project, ... and,PATH and produced by Serum Institute of ...
... CLINTON, N.J., Sept. 26 Mark Roth, Ph.D., ... received a MacArthur,Fellowship award, which includes a grant ... Roth, a member of the Fred Hutchinson ... of "no-strings-attached" support,from the John D. and Catherine ...
Cached Biology Technology:PAREXEL International Completes Acquisition of APEX International Clinical Research Co., Ltd. 2PAREXEL International Completes Acquisition of APEX International Clinical Research Co., Ltd. 3PAREXEL International Completes Acquisition of APEX International Clinical Research Co., Ltd. 4PAREXEL International Completes Acquisition of APEX International Clinical Research Co., Ltd. 5PATH, World Health Organization, and Partners Introduce Meningitis Vaccine in Burkina Faso 2PATH, World Health Organization, and Partners Introduce Meningitis Vaccine in Burkina Faso 3Ikaria Founding Scientist Named 2007 MacArthur Fellow 2
... As the world of discovery races ever ... you on the fast track. So our constant ... help accelerate your research. Thats why our Biomek ... platform thats as advanced as it is flexible. ...
... contain 60 rabbit tissue samples arrayed on Superfrost ... slides and 1 hematoxylin and eosin (H&E) stained ... different tissues from 4 rabbit organisms, for a ... tissue sample (or core) is 1.5 mm in ...
... Sigma-Genosys offers custom peptide synthesis with a wide ... best fit your research needs. Purity: ... Yield: 2mg-1g Sequence Length: ... Biotin, Fluorescein, N-acetylation, C-amidation, phosphorylation, D-amino acids, MAPs, ...
... Antigen sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 ... our corresponding peptide and ... 5 I-labelled peptide, ... (H-1470) and ([ 1 ...
Biology Products: