Navigation Links
MicroRNAs as tumor suppressors

In the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro.

"Overexpression of HMGA2 is an important feature of many medically important tumors like uterine fibroids,?explains Dr. Dutta. “It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2, and so may have a role in the causation and perhaps the cure of a disease that is responsible for the vast majority of hysterectomies in the Western world."

Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3?end of the HMGA2 transcript, and prevent let-7 binding, result in aberrantly high levels of HMGA2 expression and tumorigenesis. This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells.
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. MicroRNAs play a big part in gene regulation - and evolution
2. MicroRNAs have shaped the evolution of the majority of mammalian genes
3. MicroRNAs can be tumor suppressors
4. Mouse brain tumors mimic those in human genetic disorder
5. Researchers add new tool to tumor-treatment arsenal
6. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
7. Pulsating ultrasound enhances gene therapy for tumors
8. Scientists identify molecule that regulates well-known tumor suppressor
9. New tumor-suppressor gene discovered
10. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
11. Natural tumor suppressor in body discovered by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MicroRNAs tumor suppressors

(Date:8/18/2014)... ,Trustonic TEE technology ... devices  Trustonic, the leading provider of ... Fingerprint Cards AB (FPC) today announced a collaboration ... biometric authentication on connected devices. The ... FPC1021 and FPC1150) and sensor driver software that ...
(Date:8/18/2014)... new satellite image of Antarctica, and the imagery will ... into the effects of climate change. , Thanks to ... Dettwiler and Associates Ltd. (MDA), the prime contractor for ... (CCIN) at UWaterloo, the mosaic is free and fully ... , Using Synthetic Aperture Radar with multiple polarization modes ...
(Date:8/18/2014)... mass is made up of rangelands, which include grasslands ... alarming rate. Woody plants, such as trees and shrubs, ... loss of critical habitat and causing a drastic change ... specifically meat. , Researchers with Arizona State University,s ... this loss in both the United States and Argentina. ...
Breaking Biology News(10 mins):Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 2Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 4Waterloo makes public most complete Antarctic map for climate research 2Trees and shrubs invading critical grasslands, diminish cattle production 2Trees and shrubs invading critical grasslands, diminish cattle production 3
... sedatives have been the gold standard for treating newborns ... opiates themselves are superior to sedatives for treating infants ... pregnant. , Opiates appear to better "ameliorate the withdrawal, ... according to two new systematic reviews done by David ...
... For years, sedatives have been the gold standard for ... suggests that opiates themselves are superior to sedatives for ... methadone while pregnant. , Opiates appear to better "ameliorate ... of seizures," according to two new systematic reviews done ...
... Vast genetic resources ?"blue gold" on the international ... exploitation, warns a new report from the Japan-based ... , Increasingly recognized as important to humankind for ... resources are now more accessible and vulnerable than ...
Cached Biology News:Researchers discover new route to hemoglobin synthesis 2Opiates Better Than Sedatives For Treating Newborns In Withdrawal 2Clear rules needed to govern deep sea bioprospecting: UNU 2Clear rules needed to govern deep sea bioprospecting: UNU 3Clear rules needed to govern deep sea bioprospecting: UNU 4Clear rules needed to govern deep sea bioprospecting: UNU 5
(Date:8/19/2014)... (PRWEB) August 19, 2014 Robin Williams’ ... disease can take on an individual. Symptoms range ... facial expression, problems swallowing and severe depression. Parkinson’s ... dying off of dopamine producing neurons of the brain. ... a disease that slowly and progressively gets worse, they ...
(Date:8/19/2014)... In November 2012, the European Union (EU) ... (PBRER) in a new PSUR – responding to the increasing ... of a drug. Adopted in many regions, the main objectives ... a comprehensive and critical analysis of new or emerging information ... any new evidence of the potential benefits of a drug; ...
(Date:8/18/2014)... August 19, 2014 2014 Deep ... is a professional and in-depth research report on ... Linalool information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
(Date:8/18/2014)... Sterne, Kessler, Goldstein & Fox P.L.L.C. , an intellectual ... , announced today that it has filed eleven petitions ... U.S. Patent and Trademark Office (USPTO) on behalf of ... BRLI).  These IPR petitions aim to nullify eleven patents ... patents have been asserted against GeneDx in patent infringement ...
Breaking Biology Technology:As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 2Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 3
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) ... and Company 29th Annual Health Care Conference on Tuesday, ... parties may access a live webcast of the presentation ... is recommended that listeners log on 15 minutes early ...
... Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting ... on Tuesday, March 17, 2009 at 8:00 a.m. ... Bradbury, president and chief executive officer of Amylin Pharmaceuticals, will ... will be webcast, and a recording will be made available ...
... Research Centers in Germany and Portugal Indicates ... Wash., March 10 BioLife Solutions, Inc. ... and marketer of proprietary cGMP hypothermic storage ... and organs, today announced that an independent ...
Cached Biology Technology:Improved Cryopreservation Outcomes in Potential $100B Tissue Engineering Market Enabled by BioLife Solutions CryoStor(TM) 2Improved Cryopreservation Outcomes in Potential $100B Tissue Engineering Market Enabled by BioLife Solutions CryoStor(TM) 3Improved Cryopreservation Outcomes in Potential $100B Tissue Engineering Market Enabled by BioLife Solutions CryoStor(TM) 4
... bioassays for interferons are cytopathic effect inhibition assays, ... Sample types include; tissue culture supernatents; serum from ... assays, one unit is defined as the quantity ... cytopathic effect of viral infection by 50%. ...
... cytopathic effect inhibition assays, also known as CPE ... culture supernatents; serum from PK studies and delivery ... defined as the quantity of interferon required per ... infection by 50%. All standards used ...
... bioassays for interferons are cytopathic effect inhibition assays, ... Sample types include; tissue culture supernatents; serum from ... assays, one unit is defined as the quantity ... cytopathic effect of viral infection by 50%. ...
...
Biology Products: