Navigation Links
MicroRNA may have fail-safe role in limb development

A tiny strand of molecules plays a role in how our arms and legs develop and grow - a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University.

The research, available today in the online edition of Nature, may help scientists understand whether bits of RNA called microRNAs act as protective mechanisms in healthy development not just by strategically turning off gene activity, but by making sure it stays turned off.

More specifically, researchers report linking a specific microRNA - miR 196 - to limb development, a finding that may be useful in understanding birth defects.

Until about five years ago, genetic researchers focused on DNA, which contains all the genetic instructions for the human body, and RNA, which translates DNA's message into proteins - the building blocks of cells, organs and all of the various systems of the body.

Unnoticed next to the main ingredients, microRNAs were considered to be "junk" DNA, leftovers from millions of years of evolution. More recently, this genetic material is suspected to be part of an intricate mechanism that helps repress about one-third of our 25,000 genes. It has been linked to diabetes, hepatitis C, leukemia, lymphoma and breast cancer.

But only now have microRNAs been connected to actual growth processes.

"We found miR 196 expressed only in the hindlimbs of mice, not the forelimbs - in other words, the feet but not the hands," said Brian Harfe, Ph.D., an assistant professor of molecular genetics and microbiology in the College of Medicine and a member of the UF Genetics Institute. "In developmental biology, there has always been debate about why forelimbs are different from hindlimbs. We now think this microRNA is regulating something important in the hindlimbs but not in the forelimbs."

Scientists do not know exactly what is happening, but they think miR 196 acts a
'"/>

Source:University of Florida


Page: 1 2

Related biology news :

1. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
2. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA gene that regulates lifespan found by Yale scientists
7. MicroRNAs can be tumor suppressors
8. MicroRNA helps prevent tumors
9. MicroRNAs as tumor suppressors
10. A much-needed shot in the arm for HIV vaccine development
11. Clam embryo study shows pollutant mixture adversely affects nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MicroRNA may have fail safe role limb development

(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... , Jul. 31, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... has filed provisional patent 62/198989 for ELECTRONIC ... highlights a method to advance crypto-currencies such as Bitcoin ... a common, uniform way to manage all payments.  ...
(Date:7/27/2015)... July 27, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced that Huawei has selected the ... for its stylish smartwatch. Huawei chose the state-of-the-art ... low power and highly responsive human interface qualities ... designers also required a classic round watch face ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... WASHINGTON, Aug. 17--Researchers are able to achieve extremely ... depletion (STED) microscopy. This cutting-edge imaging system has pushed ... enabling them to image features that are even smaller ... They are able to achieve this extreme vision by ...
... Five days after the Twin Towers collapsed, two geoscientists ... were part of a team that would use remote sensing ... workers, civilians and survivors of the terrorist attacks. One of ... A second was to create a compositional profile of the ...
... have developed a simple, scalable way to align gold ... for emerging biomedical imaging technologies. Aligning gold nanorods ... on the direction in which the nanorods are pointed. ... want to ensure that all of the nanorods are ...
Cached Biology News:Researchers find way to align gold nanorods on a large scale 2
(Date:7/31/2015)... , July 31, 2015 China Cord Blood ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has filed ... Securities and Exchange Commission. The filed Form 20-F includes ... 31, 2015. The Form 20-F can be accessed by ...
(Date:7/30/2015)... MN (PRWEB) , ... July 31, 2015 , ... Ralco ... Enrichment Center at the Lyon County Fair to be held August 5-9 in Marshall. ... about where their meals come from and how agriculture impacts their daily lives. This ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report ... the current state of the global Propanol market with a focus on the Chinese ... Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... as 1 cell , Karen Dolter Jeff ... microprep kit provides a,convenient method for isolating total RNA ... bound to a solid support, which eliminates the,need for ... quality, with no detectable DNA contamination and is suitable ...
... transduction pathway of your choice , ... Cloning Systems, Inc. , The PathDetect in ... for assessing the in vivo activation of ... a unique fusion trans-activator,plasmid that expresses pathway-specific ...
... , Eagle Eye Optical Filter Optimized for ... A new optical filter has been developed for the Eagle ... increases contrast and sensitivity when imaging,silver-stained protein gels. , The ... currently sold with an optical filter optimized for imaging nucleic ...
Cached Biology Technology:Fast Isolation of Total RNA from Small Numbers of Cells 2Fast Isolation of Total RNA from Small Numbers of Cells 3Fast Isolation of Total RNA from Small Numbers of Cells 4Fast Isolation of Total RNA from Small Numbers of Cells 5Fast Isolation of Total RNA from Small Numbers of Cells 6New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 2New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 3New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 4New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 5New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 6Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3
RECK (F-20)...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
... N-(2-Naphthoyl)-Val-phenylalaninal 2-Naphthoyl-VF-CHO White lyophilized solid. ... A cell-permeable, reversible inhibitor of γ-secretase. Equipotently ... (ED 50 = 2.6 μM) and ... 2.7 μM) in HEK293 cells stably transfected ...
Biology Products: