Navigation Links
Micro-molecule plays big role in birth defects

No more than five years ago, microRNAs were considered to be little more than light seasoning in the genetic soup, distant and unnecessary cousins to the main ingredients, DNA, which contains all the genetic instructions for the human body, and RNA, which translates DNA's message into proteins - the building blocks of life.

Scientists now think the pint-sized pieces of RNA may control as much as one-third of human gene expression by seeking out and binding to messenger RNA, thereby adjusting the protein-manufacturing process.

But for microRNAs to do their jobs, scientists believe an enzyme called Dicer must be present. Harfe, who worked in collaboration with researchers at the University of California at San Francisco and the Harvard Medical School, genetically modified mice so that scientists could eliminate Dicer in specific tissues at any stage in the developmental process, thus opening a window into the role of microRNAs in limb development.

In cases where Dicer is not present in developing limb tissue, Harfe showed that microRNAs were not processed and limbs were visibly smaller.

"Many of the birth defects we see in people are mimicked by the defects we've seen in this mouse model," said Xin Sun, Ph.D., an assistant professor of genetics at the University of Wisconsin who is familiar with the research but who did not participate in it. "It indicates mutations in microRNAs might be responsible for birth defects, and this has not been discovered before. Using this same approach, we can look at other embryonic organs and ask what microRNAs do as a group."

Other research indicates microRNAs may play a role in diseases ranging from cancer to AIDS.

"There is indirect evidence that if you remove two microRNAs from the human genome, leukemia develops," Harfe said. "We envision our mouse model may be a tool to directly test how microRNAs are involved in human cancers."


'"/>

Source:University of Florida


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Sleeping beauty plays a significant role in identifying cancer genes
3. Neural stem cell gene plays crucial role in eye development
4. Got inexpensive contrast agent? Milk plays new role in imaging
5. Zinc plays important role in brain circuitry
6. Fish species plays surprise role in aiding coral reef recovery
7. Anticipation plays a powerful role in human memory, brain study finds
8. Motor protein plays key role in connecting neurons
9. Confirmed -- deforestation plays critical climate change role
10. Scientists document complex genomic events leading to the birth of new genes
11. One hit of crystal meth causes birth defects
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Micro molecule plays big role birth defects

(Date:7/11/2014)... in eastern New South Wales, Australia when NASA,s Aqua ... UTC on July 11 (12:35 p.m. local time/11:35 p.m. ... New South Wales (NSW), the Moderate Resolution Imaging Spectroradiometer ... region and spotted smoke (light brown) from various fires. ... outlined in red. , The New South Wales, Australia ...
(Date:7/11/2014)... "mouse TRAP" to capture the early signs of kidney ... the Journal of Clinical Investigation . Their new ... extract cellular and genetic information from a variety of ... Institute for Medical Research in 2008, TRAP involves attaching ... of the cell type of interest. Scientists can then ...
(Date:7/11/2014)... scientists from the Max Planck Institute for Medical Research ... in understanding photosynthesis, the process by which the Earth ... atmosphere and which is therefore crucial for all higher ... report the first direct visualization of a crucial event ... a specific protein complex, photosystem II, splits water into ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... three Canadians suffer from stress and the number is on ... the physiological state wasn,t properly named until the 1930s, new ... plagued humans for hundreds, and perhaps thousands of years. ... Journal of Archaeological Science , detected the stress hormone cortisol ...
... , WALL, N.J., Dec. 9 BIO-key ... in finger-based biometric identification solutions, today announced that ... security publications, named BIO-key International the 2009 Innovator ... Biometrics. , (Logo: http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , ...
... While supplements can help some people meet their ... is the best way for most people to obtain ... their risk of chronic disease, according to a newly ... Dietetic Association. This paper is an update of ADA,s ...
Cached Biology News:Studying hair of ancient Peruvians answers questions about stress 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 3ADA releases updated position paper on nutrient supplementation 2
(Date:7/10/2014)... of psychiatric disorders has been extremely challenging because there ... are insufficient to cause disease. Now investigators reporting in ... Cell Stem Cell describe a strategy that ... with other risk factors or environmental exposures to affect ... a genetic variant that may predispose individuals to schizophrenia. ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
(Date:7/10/2014)... will see the two universities and NPL collaborate to ... and industry and their complementary academic strengths., Working with ... shape the scientific priorities of the UK. The establishment ... 300 high-calibre PhD students, will provide a pipeline of ... potential of the Laboratory will be grown through the ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group ... is teaming up with the Heartland Blood Center and offering ... drive. The drive takes place Saturday, Jan. 18 at the ... 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... ... new indoor composting kit from SCD Probiotics. Designed to fit under most ... using SCD,s probiotic technology, helps accelerate the process and reduces foul odors normally associated ... ...
... Dragon Pharmaceutical Inc. ("Dragon Pharma" or the "Company" TSX: DDD; OTCBB: DRUG), an international ... March 31, 2010 . , , , ... Ended March 31, 2010 , , ... recorded $49.06 million of revenues for the quarter ended March 31, ...
... ... Chips , ... California (PRWEB) May 17, 2010 -- Forza Silicon Corporation announced today that the Company’s ... PJR. Forza is a leading designer and fabless turnkey supplier of CMOS imaging chips, ...
Cached Biology Technology:All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 2All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 3Dragon Pharma reports 2010 first quarter financial results 2Dragon Pharma reports 2010 first quarter financial results 3Dragon Pharma reports 2010 first quarter financial results 4Dragon Pharma reports 2010 first quarter financial results 5Forza Silicon Achieves ISO 9001 Certification 2
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet....
Plasmid expressing PLAP reporter gene....
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
...
Biology Products: