Navigation Links
Micro-molecule plays big role in birth defects

University of Florida researchers have learned how to selectively shut down a flyweight-sized genetic molecule that packs a heavyweight punch, a discovery that may help doctors better understand cancer, birth defects and other health problems.

The finding, which will be reported this week in the online Proceedings of the National Academy of Sciences, deals with tiny strands of genetic material called microRNAs.

Once thought to be little more than cellular debris, these short strands of RNA may perform a vital role in healthy development by strategically turning off gene activity.

By genetically modifying mice, scientists with the UF Genetics Institute were able to get the first-ever picture of how limbs would develop in a vertebrate without the help of microRNAs. When microRNAs were not available to turn off certain genes, the mice grew malformed, nonfunctional limbs.

The finding may provide insight into human birth defects, but scientists say its greater value will be as a new technique to study the function and malfunction of microRNAs, more than 200 types of which are thought to exist in the human body.

"We looked at limb development because it's a great place to demonstrate the technique," said Brian Harfe, Ph.D., an assistant professor of molecular genetics and microbiology in the College of Medicine and lead author of the report. "We were able to show it's feasible to eliminate the activity of microRNAs from a specific tissue while the rest of the tissue remains normal."

Had researchers inhibited microRNAs in every single cell, Harfe said the mouse embryos would survive little more than seven days after fertilization.

"That isn't enough time to study development," Harfe said. "Most structures, such as the heart, the gut and the lungs, haven't even formed yet. Now we can bypass the problem of early mortality and study the structures as they develop. It's a new tool for the genetic researcher's toolbox."


'"/>

Source:University of Florida


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Sleeping beauty plays a significant role in identifying cancer genes
3. Neural stem cell gene plays crucial role in eye development
4. Got inexpensive contrast agent? Milk plays new role in imaging
5. Zinc plays important role in brain circuitry
6. Fish species plays surprise role in aiding coral reef recovery
7. Anticipation plays a powerful role in human memory, brain study finds
8. Motor protein plays key role in connecting neurons
9. Confirmed -- deforestation plays critical climate change role
10. Scientists document complex genomic events leading to the birth of new genes
11. One hit of crystal meth causes birth defects
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Micro molecule plays big role birth defects

(Date:8/1/2014)... fossil record about 200,000 years ago, but it was ... advanced tools became widespread. , A new study ... finds that human skulls changed in ways that ... same time that culture was blossoming. , "The modern ... cultural exchange probably came at the same time that ...
(Date:8/1/2014)... Knowing what causes them at the molecular level is ... have created the most detailed map to date of ... blinding diseases, such as age-related macular degeneration. The high-resolution ... which supplies blood and oxygen to the outer retina, ... abundance of proteins in different areas of the choroid, ...
(Date:8/1/2014)... One of the most diverse families in the ocean ... lucinids) -- originated more than 400 million years ago ... like those of its modern members. This Geology ... Hawaii, published online on 25 July 2014, tracks the ... relationships. , At is origin, the Lucinidae family remained ...
Breaking Biology News(10 mins):Society bloomed with gentler personalities and more feminine faces 2A map for eye disease 2Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14
... School of Medicine have found evidence that a hormone ... functions of spatial learning and memory development, and further ... stomach. , Published in the February 19 online issue ... institutes, the study showed that the hormone ghrelin, produced ...
... cartilage offers the first hope of replacing the ... The technique, developed at Rice University's Musculoskeletal Bioengineering ... the journal Tissue Engineering. , "This has significant ... for the first time, about the potential treatment ...
... led by a University of Minnesota researcher has found a ... kinds and sizes and that may also offer a key ... be known precisely in order to construct valid models of ... occur in both plants and animals through the process of ...
Cached Biology News:Learning and memory stimulated by gut hormone 2Rice bioengineers pioneer techniques for knee repair 2Of mice, men, trees and the global carbon cycle 2Of mice, men, trees and the global carbon cycle 3
(Date:7/31/2014)... 2014 “2014 Deep Research ... Industry” is a professional and in-depth research ... introduces Polyurethane Resin basic information, including its ... and industry overview. This research covers the ... as well as global industry analysis covering ...
(Date:7/31/2014)... see through organs and even the entire body to ... cellular structures has been a long-time dream of biologists. ... 31st in the journal Cell has now ... making opaque organs, bodies, and human tissue biopsies transparent, ... protocols could pave the way for a better understanding ...
(Date:7/31/2014)... 2014 Rogne Bioscience, a privately-held biotechnology company ... , has acquired a licence to anti-inflammatory peptides from ... potent anti-inflammatory activity of the peptides was discovered by ... Oxford,s Sir William Dunn School of Pathology. ... $1.5 million in seed financing, is developing a first-in-class, ...
(Date:7/31/2014)... San Francisco, California (PRWEB) July 31, 2014 ... expert systems that inform therapeutic decision-making in oncology, today ... on August 14, 2014 to discuss the Company's financial ... to provide an update about the business in the ... live audio call beginning on Thursday, August 14, 2014, ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4See-through organs and bodies will accelerate biomedical discoveries 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... supplier of automatic identification and data collection (AIDC) software, ... their NiceLabel software. , ,The new versions of NL ... identification (RFID) tags, as well as an improved user ... programs such as Microsoft Access, Windows Event Log and ...
... Paragon Development Systems (PDS), an Oconomowoc-based IT services ... with Cisco Systems . Starting July 1, the ... services and communications markets. , ,PDS recently received Specialized ... areas in which the companies will partner; IP Communications, ...
... lawsuit on behalf of Wisconsin consumers against Microsoft can ... of last week's state Supreme Court ruling . ... seeks a settlement fund for all Wisconsin consumers for ... is that Wisconsin consumers have paid inflated prices for ...
Cached Biology Technology:Wisconsin Supreme Court rules against Microsoft 2
I-Ab MHC Class II...
... mm Culture Dishes BD BioCoat Collagen I ... a uniform application of rat tail collagen type ... ,Surface : ECM/attachment factors ,Surface ... : 60 mm x 15 mm ...
The piston kit includes 2 pistons to service one F10 pump of a BioLogic DuoFlow workstation....
BD BioCoat BD MatrigelTM Matrix 100 mm Culture Dishes for hepatocytes, tissue-culture treated polystyrene with a uniform application of MATRIGEL Matrix....
Biology Products: