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Micro RNAs play role in egg making

reas another group of eggs had normal miRNA production. (All plants and animals have DICER, the gene the produces miRNAs, so the researchers used a "genetic trick" to generate DICER-less eggs.)

In comparing overall protein production between these two groups, the researchers discovered that miRNAs stopped the manufacturing of a small group of key proteins, including ones that produce ribosomes. These structures constitute the cell's protein-making machinery, and their shutdown would render cells unable to produce new proteins.

The investigators also found that miRNAs appear to attenuate protein turnover. They speculate that this function may allow a developing egg to accumulate large amounts of specific proteins necessary to drive the amazing structural changes seen in embryogenesis.

In addition to Carthew and Minden, other authors on the PNAS paper are Kenji Nakahara and Kevin Kim of Northwestern University and Christin Sciulli and Susan Dowd of Carnegie Mellon University.


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Source:Northwestern University


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