Navigation Links
Mice with glowing hearts shed light on how hearts develop

Cornell researchers have genetically engineered mice whose hearts glow with a green light every time they beat. The development gives researchers insights into how hearts develop in living mouse embryos and could improve our understanding of irregular heartbeats, known as arrhythmias, as well as open doors to observing cellular processes to better understand basic physiology and disease.

The technique for making living, functional cells fluoresce, or glow, when the concentration of calcium ions rise within cells, is described online at http://www.pnas.org/papbyrecent.shtml and is to be published in a future issue of Proceedings of the National Academy of Sciences.

"The proteins act as molecular spies that tell us what is happening within cells in the living mouse," said Michael Kotlikoff, professor and chair of the Department of Biomedical Sciences at Cornell's College of Veterinary Medicine.

Cornell researchers are breeding new lines of mice with similar proteins that target neurons in the brain, in parasympathetic nerves, in blood vessels or in Purkinje fibers, which prompt the heart's ventricles to pump. The researchers have also transplanted cells from the mice with glowing hearts into normal mice to see whether the transplanted cells function normally within the host heart, which could offer insights for heart repair.

In the study, the mouse was engineered to express a specially designed molecule that fluoresces when calcium, which increases dramatically with each muscle contraction, is released in heart cells. Co-author Junichi Nakai of the RIKEN Brain Science Institute in Wako-shi, Japan, developed the fluorescent molecule by modifying a green fluorescent protein (derived from bioluminescent jellyfish) and making it glow brightly enough to be observed in the working heart.

Calcium turns the sensor molecule off and on like a molecular switch. Greater fluorescence indic
'"/>

Source:Cornell University News Service


Page: 1 2

Related biology news :

1. Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
2. Bone marrow stem cells may heal hearts even years after heart attacks
3. Free-radical busting antioxidants might not promote healthy hearts
4. UT Southwestern researchers find gene mutation that leads to broken hearts
5. Adult stem cell research at UB targets damaged hearts
6. Rescuing injured hearts by enhancing regeneration
7. Newts which regrow their hearts
8. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
9. Researchers discover way to make cells in the eye sensitive to light
10. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
11. Bacteria collection sheds light on urinary tract infections
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mice with glowing hearts shed light how hearts develop

(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... amounts, it can make teeth stronger and aid in the ... can be a killer a carcinogen that causes bone, ... additive in most American communities, drinking water and an ingredient ... Determining the level of fluoride, be it in water, consumer ...
... and heart attacks have been found to share common genetic ... test on developing the risk of the diseases even at ... the University of Bologna who coordinated the study published in ... test is now ready. "They are already selling it in ...
... at Virginia Tech have discovered some of the key ... inflammatory bowel disease. The results, which help researchers move ... drugs to treat inflammatory and immune-mediated diseases, are reported ... the journal Mucosal Immunology from the Nature ...
Cached Biology News:Researcher develops accurate method for detecting dangerous fluoride 2Researcher develops accurate method for detecting dangerous fluoride 3Researcher develops accurate method for detecting dangerous fluoride 4Medicine: Alzheimer's and heart attacks share the same genes 2Medicine: Alzheimer's and heart attacks share the same genes 3Immune system changes linked to inflammatory bowel disease revealed 2Immune system changes linked to inflammatory bowel disease revealed 3
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... biomaterial market will grow moderately through 2023 as the ... growing awareness of dental biomaterials all spur procedure volumes. ... as China and ... dental procedures within reach for a larger proportion of ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... 3 tropical storm that struck the low-lying and heavily populated coastline ... of the U.S. Department of Agriculture (USDA) began producing a series ... to accompany its commodity intelligence reports. , ... Redlands, ...
... Bio-Pharma Solutions, Inc.,(ABS), a global provider of ... is pleased to announce that Nandini,Hadker, an ... been promoted to,Executive Director and will oversee ... has been appointed,President & CEO of the ...
... Inc., an,acute care specialty pharmaceutical company, today announced the,appointment ... a key senior,executive to the company,s management team. Gary ... biopharmaceutical executive with more than,30 years of experience. Dr. ... the founder and past Chairman and CEO of QRx ...
Cached Biology Technology:Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 2Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 3Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 2Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 3Pacira Pharmaceuticals, Inc. Adds Board Member and Key Senior Management 2
BD IMag Anti-Mouse CD90.2 (Thy1.2) Particles-DM 2 x 109 cells...
Rabbit polyclonal to Staphylococcus Enterotoxin E (Biotin) ( Abpromise for all tested applications)....
... Ribonuclease III (RNase III) from E. ... double-stranded RNA (dsRNA) to dsRNA fragments that ... dsRNA results in dsRNA fragments of 12-15 ... RNA composed of canonical ribonucleotides as well ...
...
Biology Products: