Navigation Links
Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

eplication in the lungs. In contrast, mice injected with either of the two types of hybrid antibodies did not lose weight.

Since there was no difference in the protective abilities between the two hybrid antibodies, the researchers used 8AH8AL to determine the minimum effective dose. Groups of mice were given decreasing doses--90, 45 and 22.5 micrograms per mouse--of 8AH8AL or a single 5-mg dose of human VIG (two and a half times the recommended human dose on a weight basis) as a point of comparison. All five mice in the control group died or were sacrificed when their weight fell to 70 percent of their starting weight. All of the mice that were injected with 8AH8AL (even at the lowest dose) or with VIG were protected from death.

Further, mice that received a single 90-microgram dose of 8AH8AL two days after virus exposure experienced only slight weight loss followed by rapid recovery. Conversely, all five of the mice that received 5 mg of VIG 48 hours after virus exposure experienced much greater weight loss than those that received the hybrid antibody.

"This study demonstrated that the hybrid antibodies provide instant protection against the vaccinia virus and likely smallpox and are potentially more potent and more specific than the treatment we currently have available," says Dr. Purcell. The hybrid antibodies also offer a potentially significant advantage over VIG as a treatment for smallpox vaccination complications not only because VIG is in limited supply but because VIG lots may have different potencies and carry the potential to transmit other infectious agents, he adds.

According to Dr. Purcell, the hybrid antibodies should be tested in another animal model for effectiveness against the monkeypox virus, which closely mirrors smallpox but is less virulent in humans.

Currently, the smallpox virus exists in only two laboratories found in Atlanta, Georgia, and in Russia.


'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. New studies suggest airborne SARS transmission is possible
2. Two studies document rise of superbugs in the environment
3. UI researcher studies deafness in fruit flies, humans
4. Biased reporting found in cancer prognostic studies
5. Fruit fly studies open new window on cancer research
6. Why do aneurysms form? New studies suggest leading role for white blood cells
7. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
8. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
9. Pair of studies offer new clues to combat antibiotic resistance
10. New RNAi tools enable systematic studies of gene function
11. Ernst Mayrs theory illustrated in genetic epidemiology studies
Post Your Comments:
(Date:7/21/2015)... Connecticut , July 21, 2015  NXT-ID, ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet, announces that it has filed ... System and Method. This invention ... not only authorizes an account, but also the ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... the good, spit out the bad. A new study from ... the body,s gatekeeper. The research shows that strong bitter taste ... the sensation of nausea and display a pattern of stomach ... negative modulator of quality of life for many people, including ...
... of something extremely bittereven if you don,t swallow it at ... to set your stomach churning, according to a new study ... Cell Press publication. "This work shows that our body ... eat, even if those foods contain toxins or anti-nutrients," said ...
... (April 11, 2011) Periodontal ligament stem ... efficacious of three kinds of clinically tested dental tissue-derived ... issue of Cell Transplantation (20:2), freely available ... Seoul, South Korea, transplantation of PDLSCs into beagle dogs ...
Cached Biology News:The nauseating taste of bitter 2Bitterness induces nausea, swallowing not required 2Periodontal stem cell transplantation shows promise 2
(Date:7/31/2015)... KONG , July 31, 2015 China ... China,s leading provider of cord ... stem cell storage services, today announced that the Company ... the U.S. Securities and Exchange Commission. The filed Form ... ended March 31, 2015. The Form 20-F can be ...
(Date:7/30/2015)... USA (PRWEB) , ... July 30, 2015 , ... ... microsystems, has appointed Francois Vieillard as Sales & Marketing Director. , With ... Francois Vieillard will be responsible for reinforcing Tronics’ business development activities worldwide. He ...
(Date:7/30/2015)... 2015   Senomyx , Inc. (NASDAQ: SNMX ... to discover, develop, and commercialize novel flavor ingredients for ... financial results for the second quarter 2015. ... remain on track to achieve our commercial and financial ... of the Company. "Since our last quarterly earnings report, ...
(Date:7/30/2015)... ... ... of its 2015 growth plan and as a follow up to the recently announced expansion ... is pleased to announce that it has begun construction on a new Microbiological Laboratory. The ... strictly dedicated to basic USP 51, USP 61, and USP 62 testing specific to raw ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... profits up 31 percent for quarter ConjuGon CEO ... make Canadian cancer drug Wisconsin DOA buys Seritis ... employment Web site GE Healthcare profits ... up 31 percent from the same quarter last year, the company ...
... and businesses are entering into a major war. We ... very second, we have already entered a new front ... world in this brand-new mega-search-engine-driven e-commerce marketplace. , ,E-commerce ... Those on the front lines know exactly who is ...
... the Technology Implications of Sarbanes-Oxley earlier this year. ... emotions of CEOs, CFOs, audit committee members and external auditors ... in on their first round of reporting. , ,Wide speculation ... IT deficiencies. IT has traditionally been viewed as overhead burden ...
Cached Biology Technology:Tech Digest: whats moving in the Midwest 2Tech Digest: whats moving in the Midwest 3Global branding is now a war 2Global branding is now a war 3Global branding is now a war 4Observations from the Sarbanes-Oxley trenches 2Observations from the Sarbanes-Oxley trenches 3
Purified anti-human CD182 (CXCR2)...
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Request Info...
Polyclonal Antibody to SHPRH...
Biology Products: