Navigation Links
Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

eplication in the lungs. In contrast, mice injected with either of the two types of hybrid antibodies did not lose weight.

Since there was no difference in the protective abilities between the two hybrid antibodies, the researchers used 8AH8AL to determine the minimum effective dose. Groups of mice were given decreasing doses--90, 45 and 22.5 micrograms per mouse--of 8AH8AL or a single 5-mg dose of human VIG (two and a half times the recommended human dose on a weight basis) as a point of comparison. All five mice in the control group died or were sacrificed when their weight fell to 70 percent of their starting weight. All of the mice that were injected with 8AH8AL (even at the lowest dose) or with VIG were protected from death.

Further, mice that received a single 90-microgram dose of 8AH8AL two days after virus exposure experienced only slight weight loss followed by rapid recovery. Conversely, all five of the mice that received 5 mg of VIG 48 hours after virus exposure experienced much greater weight loss than those that received the hybrid antibody.

"This study demonstrated that the hybrid antibodies provide instant protection against the vaccinia virus and likely smallpox and are potentially more potent and more specific than the treatment we currently have available," says Dr. Purcell. The hybrid antibodies also offer a potentially significant advantage over VIG as a treatment for smallpox vaccination complications not only because VIG is in limited supply but because VIG lots may have different potencies and carry the potential to transmit other infectious agents, he adds.

According to Dr. Purcell, the hybrid antibodies should be tested in another animal model for effectiveness against the monkeypox virus, which closely mirrors smallpox but is less virulent in humans.

Currently, the smallpox virus exists in only two laboratories found in Atlanta, Georgia, and in Russia.


'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. New studies suggest airborne SARS transmission is possible
2. Two studies document rise of superbugs in the environment
3. UI researcher studies deafness in fruit flies, humans
4. Biased reporting found in cancer prognostic studies
5. Fruit fly studies open new window on cancer research
6. Why do aneurysms form? New studies suggest leading role for white blood cells
7. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
8. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
9. Pair of studies offer new clues to combat antibiotic resistance
10. New RNAi tools enable systematic studies of gene function
11. Ernst Mayrs theory illustrated in genetic epidemiology studies
Post Your Comments:
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological havoc, ... global scales. But new research from Brown University shows ... life at the time of an impact. , A ... found fragments of leaves and preserved organic compounds lodged ... Argentina. The material could provide a snapshot of environmental ...
(Date:4/17/2014)... Information about archaeological remains of ancient chili peppers in ... words for chili peppers in ancient dialects helped researchers ... value of multi-proxy data analysis. Their results are from ... in a special feature issue of the Proceedings ... and animal domestication edited by Dolores Piperno, staff scientist ...
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
Breaking Biology News(10 mins):Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Chickens to chili peppers 2Chickens to chili peppers 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... ) show a highly selective behavior towards odor ... a single olfactory stimulus is often not sufficient ... oviposition sites. Interestingly, the behavior differed between investigated ... odors (bananas, mangos) were preferred by most flies, ...
... study appearing in the Oct 1 advance online edition of ... uses stem cells to repair itself. Using mouse ... cornea is repaired from stem cells residing in the corneal ... of other stem cells that migrate from the limbus, a ...
... WI 1 OCTOBER 2008 Not only are ... George R. Brown Convention Center, beginning this weekend, to ... scientific societies, but they are bringing focus to issues ... under the theme of "Celebrating the International Year of ...
Cached Biology News:What is wild? Odor attraction among different wildtype Drosophila 2What is wild? Odor attraction among different wildtype Drosophila 3The role of stem cells in renewing the cornea 2Earth scientists keep an eye on Texas 2Earth scientists keep an eye on Texas 3Earth scientists keep an eye on Texas 4Earth scientists keep an eye on Texas 5
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... the Microsoft Education Services of Madison-based ... the two companies announced Tuesday. The I.B.I.S., Inc. / Inacom ... user applications to technical courses, including Windows Server, .NET Programming, ... Point and Saint Clare's Hospital in Weston, part ...
... Douglas Stewart Co., a provider of software and ... Mindjet Corp. to distribute Mindjet's new MindManager ... than 4,500 academic resellers and 150 college stores in ... Stewart Co., based in Madison, is the largest distributor ...
... acclaimed stem cell researcher James Thomson will receive $2 ... , ,The company, Cellular Dynamics International (CDI), ... a $1 million technology development loan through the state ... to his Grow Wisconsin agenda. Doyle said the money ...
Cached Biology Technology:Tech Digest: Inacom; St. Michael's, St. Clare's hospitals; Merge eMed; Advanced Data-Comm; Blue Cross and Blue Shield 2Cellular Dynamics getting $2 million in Wisconsin financing 2Cellular Dynamics getting $2 million in Wisconsin financing 3
... high throughput, water bath thermal cycler capable of ... This equates to 9,216 reactions per run when ... rapidly transfers a basket of plates between three ... are considerably faster than those of peltier block ...
Proliferin (C-14)...
... Dideoxycytidine is a cytidine analog that has been ... Immunogen: Chemical / Small Molecule ... specificity of the ddC antiserum was determined by ... to moles of ddC analog at the 50% ...
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
Biology Products: