Navigation Links
Mice lacking social memory molecule take bullying in stride

The social avoidance that normally develops when a mouse repeatedly experiences defeat by a dominant animal disappears when it lacks a gene for a memory molecule in a brain circuit for social learning, scientists funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) have discovered. Mice engineered to lack this memory molecule continued to welcome strangers in spite of repeated social defeat. Their unaltered peers subjected to the same hard knocks became confirmed loners ?unless the researchers treated them with antidepressants.

"For both mice and men, social status is important; for mice, losing to a dominant mouse usually means that they avoid the dominant and they avoid social situations," explained NIMH director Dr. Thomas Insel. "These new findings add to a growing literature on the molecular basis of social behavior, helping us to know where as well as how social information is encoded in the brain."

The results reveal neural mechanisms by which social learning is shaped by psychosocial experience and how antidepressants act in this particular brain circuit. They also suggest new strategies for treating mood disorders such as depression, social phobia and post-traumatic stress disorder, in which social withdrawal is a prominent symptom. Drs. Olivier Berton and Eric Nestler, University of Texas Southwestern Medical Center (UTSMC), and colleagues, report on their study in the February 10, 2005 issue of Science.

Coursing from a hub in the center of the brain (ventral tegmental area), the relevant circuit mediates responses to emotionally important environmental stimuli via release of dopamine. Activity of this neurotransmitter is regulated in the circuit by brain derived neurotrophic factor (BDNF), which is known to play a key role in memory (http://www.nimh.nih.gov/Press/prbdnf.cfm). Berton, Nestler and colleagues suspected that BDNF p
'"/>

Source:NIH/National Institute of Mental Health


Page: 1 2 3

Related biology news :

1. Mice lacking key immune component still control chronic viral infections
2. Researchers create mouse lacking key inflammation gene
3. Elephants imitate sounds as a form of social communication
4. Biologists determine genetic blueprint of social amoeba
5. Rodent social behavior encoded in junk DNA
6. Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria
7. Sudden change in social status triggers genetic response in male fish, study finds
8. Ancient DNA provides clues to the evolution of social behavior
9. ASU researchers find link between social behavior, maternal traits in bees
10. Gorilla susceptibility to Ebola virus: the cost of sociality
11. Just like us, social stress prompts hamsters to overeat, gain weight
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mice lacking social memory molecule take bullying stride

(Date:9/30/2014)... Winners of The Economist,s prestigious Innovation awards 2014 will ... at the JW Marriott Hong Kong on Friday, October 10 th ... experiences and the lessons those hold for others. The awards, which ... past decade, will be presented at a ceremony in ... be the first time the ceremony has come to ...
(Date:9/29/2014)... September 29, 2014 -- Plants have a symbiotic ... the pants extract nutrients and defend against invaders ... contaminating fruits and vegetables. Now, scientist have discovered ... of seeds; thus ensuring that sprouting plants are ... University of Notre Dame, presented their findings today ...
(Date:9/29/2014)... school? According to a new Food and Brand Lab ... can increase participation in the National School Lunch Program ... vegetables by 16%! , Chefs Move to Schools (CMTS), ... chefs with schools in order to provide nutrition instruction ... service workers. , A CMTS event was held in ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... top wheat experts today reported a breakthrough in their ability ... rapidly mutating wheat pathogen called stem rust that threatens wheat ... by farmers and scientists from fields and laboratories, the creators ... 42 million hectares of wheat in 27 developing countries in ...
... of Mexico, led by Penn State University Professor of ... Brooks of TDI Brooks International, the project,s manager, has ... the National Oceanographic Partnership Program (NOPP), an organization established ... titled "Exploration and Research of Northern Gulf of Mexico ...
... scent glands may be the key controllers of communication. ... Scientific Reports , show a clear relationship between ... communities that reside in their scent glands, said Kevin ... postdoctoral researcher. "A critical component of every animal,s ...
Cached Biology News:Researchers launch new 'Rust-Tracker' to monitor deadly wheat fungus in 27 nations 2Researchers launch new 'Rust-Tracker' to monitor deadly wheat fungus in 27 nations 3Researchers launch new 'Rust-Tracker' to monitor deadly wheat fungus in 27 nations 4Researchers launch new 'Rust-Tracker' to monitor deadly wheat fungus in 27 nations 5Researchers launch new 'Rust-Tracker' to monitor deadly wheat fungus in 27 nations 6Science research led in Gulf of Mexico by Penn State biologist to be honored with US award 2Microbes help hyenas communicate via scent 2
(Date:9/30/2014)... German . , ... demonstrated a new kind of building block for digital ... could be based on three-dimensional arrangements of nanometer-scale magnets ... the semiconductor industry CMOS fabrication of silicon chips ... at the University of Notre Dame are exploring "magnetic ...
(Date:9/30/2014)... 2014 Nematicide is a type of ... microscopic parasitic roundworms, found in massive quantities virtually ... and animals. Nematicides have tended to be broad-spectrum ... migration through the soil. A single gram of ... With more than 10,000 species classified, they are ...
(Date:9/30/2014)... CORD:USE Cord Blood Bank – www.corduse.com ... entered into an Equity and Exclusive Services Agreement with ... of patented technologies for the isolation of human cord ... is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing that the ...
(Date:9/30/2014)... Sept. 30, 2014 BioHealth Innovation, Inc. ... market-relevant biohealth innovations and increasing access to early-stage funding ... that venture capitalist, Tania Fernandez , Ph.D., has ... Fernandez will be a member of the management team ... up to $50 million in seed and early-stage equity ...
Breaking Biology Technology:A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2
... THE WOODLANDS, Texas, June 2 Lexicon Pharmaceuticals, ... the appointment of Ajay Bansal as executive vice president, corporate ... than 20 years of experience in the biotechnology and pharmaceutical ... and commercial operations. , , Prior to ...
... ... 100% digital hearing aid that does not require a prescription. , ... (PRWEB) June 2, 2009 -- For many people, hearing ... to visit a doctor. An estimated 10% of Americans suffer from hearing loss to ...
... Va. The American Institute of Aeronautics and ... of top emerging aerospace technologies. Developed by ... the following: 1. "Greener Aviation" Technologies including ... in the Federal Aviation Administration,s Continuous Low Emissions, ...
Cached Biology Technology:Lexicon Names Ajay Bansal Executive Vice President and Chief Financial Officer 2Lexicon Names Ajay Bansal Executive Vice President and Chief Financial Officer 3Prescription-Free Digital Hearing Aid Just Released 2AIAA names top ten emerging aerospace technologies of 2009 2
... rotary tables offer precision motorized rotation and ... with Parkers linear positioners and its low ... configurations., , Preloaded, precision worm gear ... race preloaded angular contact support bearing , ...
Anti-DAP-1, Rabbit Monoclonal Immunogen: KLH-conjugated synthetic peptide corresponding to the C-terminal region of human DAP-1. Molecular Weight: 11 kDa Quality Assurance: Routinely eval...
Anti-Mouse Macrophages (Metallophillic), Purified (Clone MOMA-1) (rat IgG2a)...
Request Info...
Biology Products: