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Mice lacking key immune component still control chronic viral infections

tive immune response to other chronic infectious agents.

Some current efforts to develop antiviral vaccines focus exclusively on portions of viral proteins likely to be picked up and presented by MHC Class I molecules. If these backup mechanisms are important to control of herpes and other chronic diseases, they may pick up and display other parts of viral proteins for CD8 T cells to recognize. If so, vaccine developers may need to revise their approach in order to create vaccines that trigger the most potent antiviral immune responses.

"The ultimate relevance of these backup systems to human disease isn't known yet, but it's worth noting that we never would have even known to look for them if it weren't for our ability to study genetically altered mice," he says.


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Source:Washington University School of Medicine


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