Navigation Links
Mice lacking key immune component still control chronic viral infections

weakened immune systems.

Immune system cells known as CD8 or cytotoxic T cells are responsible for recognizing virus-infected cells and killing them or sounding alarms that summon other defensive measures. To enable this recognition process, other cells regularly chop up viral proteins found in their interiors and display them on their surfaces. MHC Class I molecules act as a kind of stage for this inspection process, binding to the protein parts as they are sent to the surface and allowing CD8 T cells to recognize the presence of a foreign invader. When the CD8 T cells recognize a viral protein part, they either destroy the cell displaying the part or emit inflammatory hormones known as cytokines that trigger other immune defense measures.

Because the genetically modified mice used in their experiment lacked the genes that contain instructions for making MHC Class I molecules, Virgin and his colleagues expected to see little response from CD8 T cells when they injected the mice with herpes virus. Initially, that was exactly what they found.

"This was a study of chronic infection, though, and when we looked at the mice seven weeks later, we were surprised to find the mice making a very robust and effective CD8 T cell response," he says. "This suggests there's an alternate way of generating CD8 T cells."

The researchers believe a closely related stand-in for MHC Class I makes it possible for mouse CD8 T cells to recognize and fight the virus.

"It would be reasonable for there to be backup plans, particularly given that some viruses have evasion strategies that they use to block the classical antigen recognition processes that rely on MHC Class I," Virgin says.

Follow-up studies now underway have produced preliminary evidence that these backup plans may be active even when normal MHC Class I is engaged in the fight against chronic infection. Additional studies will look at whether the backup system can enable an ac
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Mice lacking social memory molecule take bullying in stride
2. Researchers create mouse lacking key inflammation gene
3. Fox Chase Cancer Center scientists identify immune-system mutation
4. Genetically modified natural killer immune cells attack, kill leukemia cells
5. Studies reveal methods viruses use to sidestep immune system
6. Jumping gene helps explain immune systems abilities
7. Scientists solve structure of key protein in innate immune response
8. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
9. NYU study reveals how brains immune system fights viral encephalitis
10. Chemists identify immune system mechanism for methamphetamine binges
11. Multi-purpose protein regulates new protein synthesis and immune cell development
Post Your Comments:
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD and ... on the growing mobile commerce market, announces it has retained ... for the 2015 International CES debut of the Wocket™ biometric ... be at the NXT-ID booth January 6th and 7 th ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... Water Crisis" will be the focus of a talk by Upmanu ... Nov. 16, 2011 at 3 p.m. in the NJIT Campus Center ... scarce around the world, and the time for taking effective compensating ... hear the discussion which is part of the NJIT Technology and ...
... each year, is caused primarily by infectious bacteria known as ... Mtb targets human immune cells as part of its ... Up until now, scientists had a general ... Infection Research Centre at Vancouver Coastal Health Research Institute and ...
... reveals that the release of treated municipal wastewater ... technology can have a significant effect on ... as "superbacteria," in surface waters. The study ... probably contains far greater quantities of antibiotic-resistant genes, ...
Cached Biology News:Researchers uncover why the body can't defend against tuberculosis 2New study finds that even the cleanest wastewater contributes to more 'super bacteria' 2
(Date:1/22/2015)... Wilmington, DE (PRWEB) January 22, 2015 ... the Pistoia Alliance, which helps companies check the legal ... set to expand to China. , As their ... companies are globally adopting software solutions built as a ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... December 23, 2014 Earlier this year in ... director of the Adult Stem Cell Technology Center, LLC ( ... appreciated unique property of adult tissue stem cells. His ... Past, Important for the Future,” embodied the essence of his ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... of University of Pennsylvania physicists has shown how to disrupt ... leftover after coffee drops evaporate by changing the ... to deposit uniform coatings. The research was conducted ... on the Structure of Matter; doctoral candidates Peter Yunker and ...
... Aug. 18, 2011 The Plasma Protein Therapeutics Association ... Services (CMS) take necessary steps to improve drug reimbursement ... At last week,s Advisory Panel on Ambulatory Payment ... failure by CMS to remove hospitals that purchase drugs ...
... Reportlinker.com announces that a new market ... Global Genetic Testing Market ... In a rapidly growing molecular ... attractive segment. Genetic testing is a form ...
Cached Biology Technology:Penn physicists undo the 'coffee ring effect' 2Penn physicists undo the 'coffee ring effect' 3PPTA Urges CMS for Appropriate Hospital Outpatient Reimbursement for Plasma Protein Therapies 2PPTA Urges CMS for Appropriate Hospital Outpatient Reimbursement for Plasma Protein Therapies 3PPTA Urges CMS for Appropriate Hospital Outpatient Reimbursement for Plasma Protein Therapies 4Global Genetic Testing Market Analysis 2Global Genetic Testing Market Analysis 3
... Two separate vials containing 200 ... same sequence used as antigens for ... 160890) To be ... cyclase polyclonal antiserum (Catalog No. 160890) ...
... Clone/PAD: 3B8A10. Immunogen: ... the C-terminal region of ... Specific for the human ... Human (positive control: 293 ...
... The PinPoint™ Vector Sequencing Primer is ... PinPoint™ Xa Vectors (Cat.# V2031, V2051, V2061). ... Xa site at nucleotides 325343, approximately 4050 ... region and can be used to determine ...
... The versatile Zymo-Spin I-96 Plate can be ... manifolds for the large-scale (i.e., 96-well) purification ... polypropylene construction and unique silica-based matrix make ... g DNA or RNA in = 10 ...
Biology Products: