Navigation Links
Mice lacking key immune component still control chronic viral infections

Despite lack of a key component of the immune system, a line of genetically engineered mice can control chronic herpes virus infections, researchers at Washington University School of Medicine in St. Louis have found.

Scientists can't prove it yet, but they suspect the missing immune system component, a group of molecules known as the Major Histocompatibility Complex (MHC) Class Ia, has a previously unrecognized backup that is similar enough to step in and fill the void left by its absence. If so, that backup may become a new focus for efforts to design antiviral vaccines.

"This surprising finding contradicts a long-held belief about control of viral infection: that the immune system must have MHC Class I molecules to recognize and destroy virus-infected cells," says senior author Skip Virgin, M.D., Ph.D., professor of pathology and immunology and of molecular microbiology. "It also suggests that we may need to take a more extensive look at what immune system elements play a role in controlling chronic viral infections."

The study will be published in the May issue of Public Library of Science Pathogens.

In chronic herpes virus infections, the body brings the invader under control, reducing its replication and spread, but is unable to completely eliminate it, resulting in lifelong infection.

The mice in the study were injected with murine gamma herpes virus 68, a herpes virus that infects mice and is closely related to the human gamma herpes viruses Epstein-Barr virus (EBV, the cause of mononucleosis) and Kaposi's sarcoma-associated herpes virus (KSHV, the cause of a form of cancer known as Kaposi's sarcoma). Other herpes viruses that infect humans include the alpha herpes viruses herpes simplex virus 1 and 2, which cause cold sores and genital herpes, and varicella zoster virus, which causes chickenpox. Infection with gamma herpes viruses such as EBV and KSHV increases the risk of some cancers, especially in persons with
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Mice lacking social memory molecule take bullying in stride
2. Researchers create mouse lacking key inflammation gene
3. Fox Chase Cancer Center scientists identify immune-system mutation
4. Genetically modified natural killer immune cells attack, kill leukemia cells
5. Studies reveal methods viruses use to sidestep immune system
6. Jumping gene helps explain immune systems abilities
7. Scientists solve structure of key protein in innate immune response
8. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
9. NYU study reveals how brains immune system fights viral encephalitis
10. Chemists identify immune system mechanism for methamphetamine binges
11. Multi-purpose protein regulates new protein synthesis and immune cell development
Post Your Comments:
(Date:8/28/2014)... is available in German . ... owes its name to a striking pattern of blue stripes ... cells, reflective silvery cells, and yellow cells emerge during growth ... as a multilayered mosaic to compose the characteristic colour pattern. ... types have to interact to form proper stripes, the embryonic ...
(Date:8/28/2014)... Researchers at the University of Minnesota have developed ... to be used for muscle regeneration research as well ... FSHD. , The research is published in the current ... There is no treatment for FSHD, which is thought ... muscular dystrophy. FSHD is an unusual genetic disorder because, ...
(Date:8/28/2014)... Advocate and Senior Staff Attorney at the Electronic Frontier ... of biometric and mobile commerce experts set to speak ... Tampa, Florida on September 15, ... Rahman, Director, Technology and Strategy at Samsung, and Philippe de ... this year,s event is Mobility at the Crossroads of ...
Breaking Biology News(10 mins):How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3UMN researchers find animal model for understudied type of muscular dystrophy 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... noninvasive, polarized light microscope invented at the Marine Biological ... breakthrough in embryonic stem-cell research aimed at developing medical ... of Oregon Health & Science University reported the ... in the November 22 issue of Nature. While embryonic ...
... a traumatic brain injury and using club drugs have in ... a similar chemical chain reaction in the brain, leading to ... A series of studies at UF over the past ... also called MDMA, and other forms of methamphetamine lead to ...
... Boulder, CO, USA - Topics include: onset of plate ... climate system; cause of the end-Permian mass extinction; Olduvai ... ancient mantle plume and the break-up of Rodinia; relationship ... composition and eruption forecasting; and cause of the end ...
Cached Biology News:Oosight microscope enables embryonic stem cell breakthrough 2Oosight microscope enables embryonic stem cell breakthrough 3Oosight microscope enables embryonic stem cell breakthrough 4Club drugs inflict damage similar to traumatic brain injury 2Club drugs inflict damage similar to traumatic brain injury 3December GEOLOGY and GSA TODAY media highlights 2December GEOLOGY and GSA TODAY media highlights 3December GEOLOGY and GSA TODAY media highlights 4December GEOLOGY and GSA TODAY media highlights 5December GEOLOGY and GSA TODAY media highlights 6December GEOLOGY and GSA TODAY media highlights 7December GEOLOGY and GSA TODAY media highlights 8December GEOLOGY and GSA TODAY media highlights 9December GEOLOGY and GSA TODAY media highlights 10
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... 2014 Three Lawrence Livermore researchers ... Hydrogen Production R&D Award for their research ... using sunlight. , Shared with collaborators from the ... of Nevada, Las Vegas (UNLV), the award recognizes ... photoelectrochemical solar-hydrogen production and corrosion processes. , These ...
(Date:8/29/2014)... 2014 A major challenge before new ... dense realm of Boston-Cambridge, is gaining visibility that can ... Sherley, the Director of Boston’s Adult Stem Cell Technology ... national visibility of his company an important priority since ... addition to a social media marketing campaign ...
(Date:8/28/2014)... SAN DIEGO, California, USA (PRWEB) August 28, 2014 ... at the Department of Physics and Optical Science and ... at the University of North Carolina at Charlotte, and ... has been elected to serve as the 2015 Vice ... photonics. , SPIE 2014 President Philip Stahl announced recent ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... often been regarded as the economic motor of the European ... of Scandinavia, to the east of the U.K. and France, ... the east European countries of Poland, the Czech Republic and ... not only one of Europes largest populations but considering ...
... of Healthcare Expected - Connecting Information For Better, ... (NYSE: GE), through its GE Medical Systems division, ... , ,The merger is one of the ... healthcare information industry and is expected to accelerate ...
... success of biotechnology in Illinois and the Midwest? We could ... companies in Illinois ,Increase in new emerging companies ... the financial markets ,Increase in market cap of the ... and indirectly ,Number of new life science patents produced ...
Cached Biology Technology:German Life Science Oktoberfest Comes to the Midwest 2German Life Science Oktoberfest Comes to the Midwest 3German Life Science Oktoberfest Comes to the Midwest 4German Life Science Oktoberfest Comes to the Midwest 5German Life Science Oktoberfest Comes to the Midwest 6GE Acquires Instrumentarium 2Finding a Yardstick For Local Biotech Improvement and Success 2Finding a Yardstick For Local Biotech Improvement and Success 3
... Molecular Probes is pleased to ... for the ultrasensitive detection of primary ... at Indiana University, the ATTO-TAG reagents ... o-phthaldialdehyde (OPA), naphthalene-2,3-dicarboxaldehyde (NDA) and anthracene-2,3-dicarboxaldehyde, ...
Troponin I (22B11)...
... ultra low temperature freezers offer a ... storage of biological samples with high ... separate inner doors ensure excellent warming ... ,Application oriented accessories simplify tracking ...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
Biology Products: