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Metal-containing compounds show promise as HIV weapon

proteases from working.

Other advantages are that the compounds are stable and can be modified in many ways by attaching other strings of atoms to them. Further research may reveal that one modified version may be more stable or less toxic than another, for example.These compounds were also found to bind to the protease in a different location than the current class of protease inhibitors, so they may be effective against HIV strains that have become resistant to that class.

Dr. Pavlina Rezacova, postdoctoral researcher in biochemistry at UT Southwestern, also participated in the study, as did researchers from the Academy of Sciences of the Czech Republic; the Institute of Chemical Technology and Charles University in the Czech Republic; the University of Heidelberg in Germany.


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Source:UT Southwestern Medical Center


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