Navigation Links
Metal-containing compounds show promise as HIV weapon

A molecule consisting of two "cages" of metallic atoms bound to carbon has shown great promise in preliminary tests of becoming a new weapon in the anti-HIV arsenal, researchers at UT Southwestern Medical Center report. The molecule - called metallacarborane - and its variants appear to fight HIV protease, an enzyme critical in the virus' life cycle. Protease inhibitors are some of the key drugs used to fight HIV/AIDS, but they have side effects, and viruses can develop resistance to them.

"This molecule has all the characteristics of a good starting point for a new class of compounds," said Dr. Zbyszek Otwinowski, associate professor of biochemistry at UT Southwestern and an author on the study, which appears in the Proceedings of the National Academy of Sciences and is currently available online.

Researchers from UT Southwestern, the Czech Republic and Germany studied the structure and inhibition properties of the basic molecule as well as several variants with chains of other atoms hanging off them. The researchers found that at very low concentrations, the new molecules inhibit protease in infected cultured human cells with no obvious toxicity toward the cells.

The 12-pointed, cagelike molecule of boron bound to carbon, called carborane, has been known for more than 50 years but just recently came to the attention of researchers in the Czech Republic as a possible AIDS drug, Dr. Otwinowski said.

The Czech group bound the metallacarboranes they were studying to the proteases, then brought the diffraction data to UT Southwestern to have the structures interpreted. The structures were determined by a process called X-ray crystallography, in which the crystals are bombarded with X-rays, and then the patterns made when the component atoms deflect the rays are deciphered.

The metallacarboranes appeared to occupy the portion of the protease used to hold key proteins in place as part of the infective cycle of HIV, preventing the
'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Seaweed yields new compounds with pharmaceutical potential
7. Phenolic compounds may explain Mediterranean diet benefits
8. Marijuana-like compounds suppress the immune response
9. Legume compounds may help cancer treatment
10. Microbes transform safest PBDEs into more harmful compounds
11. Harvard scientists identify compounds that stimulate stem cell growth in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Metal containing compounds show promise HIV weapon

(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
(Date:8/28/2014)... to alert the world to Global Warming, has called ... stored underground. He says that Carbon Capture, combined with ... to avoid global warming getting out of control over ... York) made the call during his presentation to the ... are meeting to discuss Carbon Capture and Storage. ...
(Date:8/28/2014)... action is needed to ensure safeguards are in place ... PLOS ONE , researchers from Monash University, Stellenbosch ... combining results from different studies - to look at ... to determine whether they actually protect biodiversity. , ... an area from human exploitation made common sense, however, ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Protected areas proven to protect biodiversity 2
... way to fight obesity-related illness has been uncovered, thanks ... Western Reserve University School of Medicine. The collaborators, ... and Cornell University, discovered the essential nutrient vitamin E ... obesity. "The implications of our findings could have a ...
... A research team led by Cornell University,s Creative Machines ... to witness virtual creatures evolving their squishy, muscle-like features in ... concepts from developmental biology and how nature builds complex animals ... of bizarre, simulated robots that evolve a diverse series of ...
... disease affecting a person,s ability to coordinate and control ... in a finger will eventually lead to difficulty in ... without assistance. Since the 1950s research has shown that ... dopamine in their brains, which is involved in sending ...
Cached Biology News:Vitamin E identified as potential weapon against obesity 2Vitamin E identified as potential weapon against obesity 3New research examines connection between inflammatory stimulus and Parkinson's disease 2New research examines connection between inflammatory stimulus and Parkinson's disease 3
(Date:8/29/2014)... According to a new market report published by ... was valued at USD 3,754.6 million in 2012 and is ... a CAGR of 5.9% from 2013 to 2019. , Nearly ... afflicted by bone and joint disorders, and this number is ... and will continue to increase the demand for orthobiologics. Other ...
(Date:8/29/2014)... 29, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... financial results for the six months ended June ... in Canadian dollars and presented under International Financial ... Highlights , Announced top-line results related ... endpoint for subjects enrolled in the Phase 2 ...
(Date:8/29/2014)... 29, 2014 Three Lawrence Livermore ... Hydrogen Production R&D Award for their ... water using sunlight. , Shared with collaborators from ... University of Nevada, Las Vegas (UNLV), the award ... of photoelectrochemical solar-hydrogen production and corrosion processes. , ...
(Date:8/29/2014)... MA (PRWEB) August 29, 2014 A ... in the biotech start-up dense realm of Boston-Cambridge, is ... and able investors. James Sherley, the Director of Boston’s ... increasing the local and national visibility of his company ... September 2013. , In addition to a social media ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4
... demonstrates company,s commitment to sustainabilityLAS VEGAS, April 22 ... commitment to protecting tomorrow today through its sustainability ... Region for Bayer CropScience, presented Tom Lovelace, United ... million endowment over the next four years to ...
... Cohen to be inducted into National Academy of Sciences for ... Sir Philip Cohen of Scotland,s University of Dundee ... (NAS) during its 146th annual meeting on Saturday, April 25 ... in original scientific research. Sir Philip is one of only ...
... (Pink Sheets: MNCN), an innovative, global wellness solutions company, ... (BPS), operating under the MPS-BioPharm name (MPS), received both ... to utilize MPS, Equity by Design ... fit and purpose related to design, constructability and cleanliness. ...
Cached Biology Technology:Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 2Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 3Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 4United States Recognizes Leading Scottish Scientist for Disease Research 2Mach One BioPharm Process Operating Group Receives Contract From American Beef Processors 2Mach One BioPharm Process Operating Group Receives Contract From American Beef Processors 3
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... Life Science FLA-8000 Fluorescent Image Analyzer features ... single laser imaging system. This powerful new ... with fluorescent dyes or radioisotopes at resolutions ... laboratories. Speed, image quality and flexibility make ...
...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
Biology Products: