Navigation Links
Metal-containing compounds show promise as HIV weapon

A molecule consisting of two "cages" of metallic atoms bound to carbon has shown great promise in preliminary tests of becoming a new weapon in the anti-HIV arsenal, researchers at UT Southwestern Medical Center report. The molecule - called metallacarborane - and its variants appear to fight HIV protease, an enzyme critical in the virus' life cycle. Protease inhibitors are some of the key drugs used to fight HIV/AIDS, but they have side effects, and viruses can develop resistance to them.

"This molecule has all the characteristics of a good starting point for a new class of compounds," said Dr. Zbyszek Otwinowski, associate professor of biochemistry at UT Southwestern and an author on the study, which appears in the Proceedings of the National Academy of Sciences and is currently available online.

Researchers from UT Southwestern, the Czech Republic and Germany studied the structure and inhibition properties of the basic molecule as well as several variants with chains of other atoms hanging off them. The researchers found that at very low concentrations, the new molecules inhibit protease in infected cultured human cells with no obvious toxicity toward the cells.

The 12-pointed, cagelike molecule of boron bound to carbon, called carborane, has been known for more than 50 years but just recently came to the attention of researchers in the Czech Republic as a possible AIDS drug, Dr. Otwinowski said.

The Czech group bound the metallacarboranes they were studying to the proteases, then brought the diffraction data to UT Southwestern to have the structures interpreted. The structures were determined by a process called X-ray crystallography, in which the crystals are bombarded with X-rays, and then the patterns made when the component atoms deflect the rays are deciphered.

The metallacarboranes appeared to occupy the portion of the protease used to hold key proteins in place as part of the infective cycle of HIV, preventing the
'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Seaweed yields new compounds with pharmaceutical potential
7. Phenolic compounds may explain Mediterranean diet benefits
8. Marijuana-like compounds suppress the immune response
9. Legume compounds may help cancer treatment
10. Microbes transform safest PBDEs into more harmful compounds
11. Harvard scientists identify compounds that stimulate stem cell growth in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Metal containing compounds show promise HIV weapon

(Date:9/17/2014)... a new crime unit designed to fight food fraud ... horse meat being passed off as beef scientists ... adulteration. They describe their approach, which represents a vast ... Agricultural and Food Chemistry . , Hans-Ulrich Humpf and ... economic problem. But they also say that adding, for ...
(Date:9/16/2014)... for Children,s Environmental Health at the Mailman School of ... between childhood asthma and prenatal exposure to two phthalates ... appear online in the journal Environmental Health Perspectives ... pregnancy to higher levels of the chemicals, butylbenzyl phthalate ... and 78 percent increase in risk of developing asthma ...
(Date:9/16/2014)... September, 2014)More than $100 trillion in cumulative public ... carbon dioxide (CO2)a 40 percent reduction of urban ... the world expands public transportation, walking and cycling ... by the University of California, Davis, and the ... , Further, an estimated 1.4 million early deaths ...
Breaking Biology News(10 mins):Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 2Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 4Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 5
... Wireless ... for Emergency Responders, WALL, N.J., Oct. 15 BIO-key ... and wireless public safety solutions, today announced that,it will be ... Chiefs of Police (IACP) Conference and,Exposition, October 15-17 at the ...
... (AD) is a progressive neurodegenerative disorder characterized by ... amyloid plaques and neurofibrillary tangles. Neuronal and synaptic ... occur in specific brain areas involved in memory ... cerebral deposition of A" plays a seminal role ...
... to ramp up testosterone production appears to drive male ... comes with an evolutionary cost. Big fluctuations in testosterone ... their own young, scientists have learned. In ... Indiana University Bloomington, University of Virginia and University of ...
Cached Biology News:BIO-key International Showcasing Innovative Public Safety Solutions at 2007 IACP Conference 2BIO-key International Showcasing Innovative Public Safety Solutions at 2007 IACP Conference 3Paradigm shift in Alzheimers's research: new treatments 2Paradigm shift in Alzheimers's research: new treatments 3Paradigm shift in Alzheimers's research: new treatments 4Testosterone turns male juncos into blustery hunks -- and bad dads 2Testosterone turns male juncos into blustery hunks -- and bad dads 3
(Date:9/17/2014)... 17, 2014 BioClinica®, Inc., a leading provider ... announced three of its experts are speaking at the ... Management to be held September 28 to October 1 ... Company also announced the innovative Compass technology, ... clinical trials acquired earlier this year, is up for ...
(Date:9/17/2014)... 2014 Intarcia Therapeutics, Inc. today ... study of the cost and predictability of non-adherence in ... Annual Meeting of the European Association for the Study ... Christian Frois , Ph.D., of Analysis Group, Inc. presented ... Intarcia-sponsored, retrospective studies to characterize the prevalence of non-adherence ...
(Date:9/17/2014)... SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), a life ... products for advanced microarray diagnostics, today announced that its ... the United States on the OTCQX ... 17, 2014 on the OTCQX under the symbol SQIDF.  ... Venture Exchange under its existing symbol SQD. ...
(Date:9/17/2014)... California , 17 de septiembre de ... ("la compañía"), principal proveedor mundial de soluciones ... las ciencias de la vida, anunció hoy ... de logística global con sede en Rótterdam, ... base de clientes Europa en rápido crecimiento. ...
Breaking Biology Technology:BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... to Accelerate Workflow, CHICAGO, Nov. 27 ... the MAMMOMAT(R) Novation S, a new,digital mammography ... at the 93rd Scientific Assembly and Annual ... (RSNA) from Nov. 25 to 30 at,McCormick ...
... of Health, Labor and Welfare (MHLW), for the revolutionary ... ... the blood, IRVINE, Calif., Nov. 27 Masimo, the ... today announced approval of the Masimo Rad-57 Pulse CO-Oximeter,bringing the ...
... UCLA,s California NanoSystems Institute, the David Geffen School of ... have modeled the structure of the largest cellular particle ... drug delivery. , The research study, ... as a drug-therapy vehicle, appears in the Nov. 27 ...
Cached Biology Technology:Siemens Unveils New Digital Mammography System for Optimized Screening 2Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 2Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 3Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 4Researchers outline structure of largest nonvirus particle ever crystallized 2
Peptide-affinity Purified Polyclonal Antibody to Purinergic Receptor P2Y12...
Purified anti-PXR...
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Purified anti-DNA-PKcs Phosphorylated (Thr2609)...
Biology Products: