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Melanoma vaccine strategy shows promise in laboratory experiments

fessor Brian Czerniecki, M.D., Ph.D., is working to prepare yet another type of immune cell, called a dendritic cell, to present the BRAFV600E peptide to killer T cells. Dendritic cells have as their primary job the presentation of foreign materials to the immune system, and the expectation is that dendritic cells presenting the BRAFV600E peptide would trigger the killer T cells even more effectively than the monocyte cells used in the current study. Indeed, such prepared dendritic cells might serve as the basis for a treatment vaccine that could be taken into human clinical trials.

Herlyn is senior author on the Cancer Research study. The lead author is Rajasekharan Somasundaram, also at Wistar. The additional Wistar coauthors are Rolf Swoboda, Laura Caputo, and Laszlo Otvos (now at Temple University). The remaining coauthors are Barbara Weber, Patricia Volpe, Patricia van Belle, Susan Hotz, David E. Elder, Lynn Schuchter, DuPont Guerry, and Brian J. Czerniecki of the University of Pennsylvania, and Francesco M. Marincola with the National Institutes of Health.


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Source:The Wistar Institute


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