Navigation Links
Mechanisms involved with tumor relapse identified

Researchers at Virginia Commonwealth University’s Massey Cancer Center studying the interaction between the immune system and cancer cells have identified interferon gamma as one of the signaling proteins involved with tumor relapse.

The findings may help researchers develop tailored vaccines and other immunotherapeutic strategies to fight a number of cancers. Immunotherapy involves the manipulation of the immune system ?by introducing an antibody or lymphocytes, or immunization with a tumor vaccine ?to recognize and eradicate tumor cells.

Using a transgenic mouse model of breast cancer, researchers found that interferon gamma, a cytokine or chemical messenger that is produced by cells of the immune system upon activation, plays a role in tumor relapse. In humans, interferon gamma is also produced by white blood cells of the immune system in response to invasion by pathogens or tumors in order to protect the host against infection or cancers. Production of interferon gamma by lymphocytes against tumors is considered a sign of good prognosis; however, recent study findings indicate that this may not be the case. The findings were reported in the March 2007 issue of the European Journal of Immunology, the official journal of the European Federation of Immunological Societies.

"By understanding the molecular mechanisms involved with tumor relapse, we can create tailored vaccines that can induce specific types of immune responses in patients, rather than inducing a broad range of immune responses - some of which may be detrimental or may induce tumor relapse," said lead investigator, Masoud H. Manjili, D.V.M., Ph.D., a member scientist with the Massey Cancer Center.

"Ultimately, we hope to offer a new polypeptide vaccine approach that induces tumor killing without causing HER-2/neu loss. Loss of HER-2/neu is a mechanism that tumors utilize to escape the immune-mediated destruction," he said.

Since 2000, Manjili and his col
'"/>

Source:Virginia Commonwealth University


Page: 1 2

Related biology news :

1. UCSD research reveals mechanism involved with type of fatal epilepsy
2. Researchers discover key gene involved in bark beetle pheromone production
3. High-powered gene profiles provide clues to genes involved in common form of lung cancer
4. Molecular steps involved in the creation of gene-silencing microRNAs identified
5. Hunt for human genes involved in cell division under way
6. Genes involved in biofilms
7. Genes involved in cell growth and cell division identified
8. Scientists identify gene involved in stem cell self-renewal in planaria
9. Key molecular signaling switch involved in allergic disease identified
10. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
11. Pleasure and pain: Study shows brains pleasure chemical is involved in response to pain too
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mechanisms involved with tumor relapse identified

(Date:8/21/2014)... researchers at Louisiana Tech University has developed ... 3D printers and materials to fabricate custom ... chemotherapeutic compounds for targeted drug delivery. , ... research faculty from Louisiana Tech,s biomedical engineering ... filament extruders that can make medical-quality 3D ...
(Date:8/20/2014)... pregnant teenagers in Rochester, NY, nearly half engaged in ... cornstarch, vacuum dust, baby powder and soap, and other ... such teens had significantly lower iron levels as compared ... Pregnant teens, regardless of pica, are at higher risk ... and anemia. Low iron in pregnant teens raises the ...
(Date:8/20/2014)... are visible in in this image of the Para ... these were most likely intentionally set in order to ... forest or stand of trees where the land is ... include conversion of forestland to farms, ranches, or urban ... green of the Amazon Rainforest in the middle of ...
Breaking Biology News(10 mins):Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Pica in pregnant teens linked to low iron 2
... trees that once characterized expansive tracts of tropical rainforest ... Just how big a role these winged gardeners play ... at Chicago and several Latin American universities are about ... laboratory in Mexico's gulf coast state of Veracruz. , ...
... plants such as corn, soybeans and sunflowers into fuel ... biodiesel generates, according to a new Cornell University and ... energy benefit to using plant biomass for liquid fuel," ... Cornell. "These strategies are not sustainable." , Pimentel and ...
... structural details of a family of mysterious objects called ... of bacteria. The discovery was published Aug. 5 in ... at how microcompartments are built, and what the pieces ... chemistry and biochemistry, and a member of the UCLA-DOE ...
Cached Biology News:Birds and bats sow tropical seeds 2Birds and bats sow tropical seeds 3Ethanol and biodiesel from crops not worth the energy 2New discovery blurs distinction between human cells and those of bacteria 2New discovery blurs distinction between human cells and those of bacteria 3
(Date:8/21/2014)... 2014 Mathematic studies at the Program for ... funded by the Jeffrey Epstein VI Foundation , have ... visually identified for elimination. These aggressive cells are the driver ... a topological map of what to look for when examining ... while tumor cells can be extracted from biopsy, it,s very ...
(Date:8/21/2014)... Sofia, Bulgaria (PRWEB) August 21, 2014 ... was released today by Ontotext . Now ... and semantic analysis of structured and unstructured data is ... of the cost of enterprise technology. Organizations that do ... approaches for data management can use S4 since there ...
(Date:8/20/2014)... licensed to biotechnology firms has revealed early bottlenecks ... roadblocks, the researchers suggest that better communication of ... lead to faster commercialization down the road. , ... in university laboratories and licensed to biotechnology firms. ... have a high failure rate. But a new ...
(Date:8/20/2014)... Mass. , Aug. 20, 2014  Decision Resources Group finds ... , Russia , India ... $1.6 billion in 2013, roughly equal to the size of ... however, the BRIC market will experience much faster growth as a ... aging population. Other key findings from Decision Resources Group,s ...
Breaking Biology Technology:Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3
... ROCKVILLE, Md., Jan. 9, 2012  Neuralstem, Inc. (NYSE Amex: ... Richard Garr will present at the 2012 Biotech Showcase ... Garr will serve on the Therapeutic Focus Panel entitled, ... Alliance for Regenerative Medicine (ARM) Insight Track. Garr will ...
... WOBURN, Mass., Jan. 9, 2012 Advanstar|CBI recently announced ... and Access Programs. The Forum takes place March 6-7, ... includes leading experts from Eli Lilly, Genentech, AstraZeneca, Shire ... Patient Assistance Pavilion participant Needy Meds recently interviewed PAP,s ...
... Jan. 9, 2012   Veracyte, Inc ., a ... molecular cytology, today announced that Palmetto GBA, a ... coverage for the company,s Afirma Gene Expression Classifier ... that Veracyte,s genomic test is now accessible to ...
Cached Biology Technology:Neuralstem President and CEO to Update Ongoing ALS and NSI-189/Major Depressive Disorder Trials at 2012 Biotech Showcase 2Neuralstem President and CEO to Update Ongoing ALS and NSI-189/Major Depressive Disorder Trials at 2012 Biotech Showcase 3Veracyte Announces Medicare Coverage for Its Afirma® Gene Expression Classifier for Improved Thyroid Nodule Diagnosis 2Veracyte Announces Medicare Coverage for Its Afirma® Gene Expression Classifier for Improved Thyroid Nodule Diagnosis 3
synphilin-1 (V-19)...
... contains the basic components required for the ... and recombinant canine Monocyte Chemotactic Protein 1 ... Each kit contains sufficient materials to run ... that the following conditions are met:2 ...
... MaV203 Competent Yeast Cells are designed for ... 1). S. cerevisiae strain MaV203 contains deletions ... for use with GAL4-based two-hybrid systems. The ... for selection of ProQuest bait and prey ...
Anti-Cullin-1 Host: rabbit polyclonal Species Reactivity: human, mouse Applications: IHC(P), WB, IP Storage: 4C...
Biology Products: