Navigation Links
Mechanism of nicotine's learning effects explored

While nicotine is highly addictive, researchers have also shown the drug to enhance learning and memory—a property that has launched efforts to develop nicotine-like drugs to treat cognitive deficits in Alzheimer’s and Parkinson’s diseases, schizophrenia, and attention-deficit/hyperactivity disorder.

A key problem in designing such drugs has been that little was known about the detailed mechanism by which nicotine exerts its learning-enhancing effects.

Now, researchers have discovered important details of how nicotine adjusts the signaling properties of neuronal wiring to enhance memory. Such signaling properties include the strength of the connections by which one neuron triggers another. Huibert Mansvelder and colleagues reported their findings in the April 5, 2007, issue of the journal Neuron, published by Cell Press.

The researchers made their discoveries by analyzing the electrophysiological properties of neurons in slices of mouse brain, as they treated the slices with nicotine or with drugs that prevent nicotine’s action. Specifically, the researchers studied the neurons of the prefrontal cortex, which contain centers for learning and memory.

Researchers had known that nicotine enhances learning by activating receptors for the neurotransmitter acetylcholine. Such neurotransmitters are the chemical signals that one neuron launches at another to trigger a nerve impulse in the receiving neuron.

In their studies, Mansvelder and colleagues found that by activating acetylcholine receptors, nicotine affects a process called “spike-timing-dependent potentiation?that governs changes in strength of signaling connections among neurons. What’s more, the researchers traced this effect to nicotine’s action on specific kinds of neurons, called GABAergic neurons, in the learning centers. In turn, the effects on GABAergic neurons affected signaling between neurons mediated by the key substance calcium.

The researchers a lso discovered key details of the mechanisms by which nicotine excites different kinds of “interneurons?in the prefrontal cortex. Interneurons are the way-stations for neuronal impulses, passing neuronal signals from one neuron to another.


'"/>

Source:Cell Press


Related biology news :

1. Mechanism for the captation of nutrients in plants- unknown to date
2. Mechanism regulating tooth shape formulation found
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism identified for promising neurological drug
6. Mechanism for neurodenegerative diseases linked to transport proteins
7. Mechanisms involved with tumor relapse identified
8. Dissecting the machinery of nicotines reward
9. New research identifies gene important for nicotines effects on the brain
10. Structure-building cell signals also may influence learning and memory
11. Building a protein name dictionary from full text: a machine learning term extraction approach
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
(Date:10/6/2017)... ... 06, 2017 , ... On Tuesday, October 24th, ABC² (Accelerate ... first-ever adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. ... open to the public, but registration is required. , WHAT: ABC² Brain ...
Breaking Biology Technology: