Navigation Links
Mechanism identified for promising neurological drug

negative. "In blocking PARP-1, you block DNA repair," he cautions. "That will likely be true of minocycline. And in blocking DNA repair you conceivably increase the risk of cancer. In clinical trials where people are taking minocycline for months at a time, I think that investigators need to take this into consideration ?although for someone with a serious neurodegenerative disease like ALS, it could be a reasonable tradeoff. But you want to have your eyes open."

Another implication has to do with gender differences: PARP-1 stimulates an inflammatory response much more strongly in males than in females, "across all species that have been looked at," says Swanson. "It's unclear why that's true. But again, that means we need to look at whether minocycline has the same effects on women as in men. And as far as I know, that's not being looked at."

The study results also have a potential positive implication directly bearing on research that Swanson is currently conducting on possible ways to prevent brain cell death and promote new brain cell growth after stroke. "It turns out that both of these effects can be accomplished by blocking PARP-1 activation after stroke," he says. "Up to this time, we've been doing that with bona fide PARP inhibitors. We intend now to look at minocycline in the same vein."


'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Mechanism for the captation of nutrients in plants- unknown to date
2. Mechanism regulating tooth shape formulation found
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism for neurodenegerative diseases linked to transport proteins
6. Mechanisms involved with tumor relapse identified
7. Mechanism of nicotines learning effects explored
8. Source of molecular triggers in cutaneous T cell lymphoma identified
9. Key molecule in plant photo-protection identified
10. Critical role in programmed cell death identified
11. Asthma gene clusters identified
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mechanism identified for promising neurological drug

(Date:12/22/2014)... , Dec. 22, 2014 Research ... has announced the addition of the ... report to their offering. ... insight provides an overview of the global ... aims to control and monitor piracy by ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and ... addition of the "Micro Market Monitor: North America ... http://photos.prnewswire.com/prnh/20130307/600769 ... grow at a CAGR of 3.6% from 2014 to ... in this market, Canada is ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 ... than the iPhone 5S, Samsung introduces for the ... The Galaxy S5 home button presents ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... Pittsburgh of UPMC have identified a potential target ... trachomatis, the most prevalent sexually transmitted bacterial infection ... Toni Darville, MD, chief of the Division of ... strain of Chlamydia that, when investigated in an ...
... artificial heart-valve replacements face several repeat operations as they ... and must be traded for bigger ones. Researchers at ... growing valves created in the lab from a patients ... published September 11, they describe making pulmonary valves through ...
... critical to how successful treatment can be. Therefore, the ... field, where every small step is of great importance. ... Cellular Proteomics, Uppsala University researchers describe a technique that the ... bodys cells and tissues, and our knowledge of the human ...
Cached Biology News:Study by Pittsburgh researchers identifies possible vaccine target for chlamydia 2A step toward tissue-engineered heart structures for children 2
(Date:12/24/2014)... Sigma-Aldrich Corporation (NASDAQ: SIAL ... the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in ... 2014, thereby completing the U.S. HSR Act antitrust ... the Company by Merck KGaA, Darmstadt, Germany.  ... to closing the transaction, which remains subject to ...
(Date:12/22/2014)... 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, with ... announced positive topline safety and tolerability results ... SYN-004, the Company,s investigational oral beta-lactamase enzyme ... (C. difficile) infection, antibiotic-associated diarrhea and ...
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) — ... online medical bill review and advocacy service, has signed ... FREE WellCard Savings discount health services marketplace. ... was more than they expected to pay. As part ... care costs, WellCard Savings is pleased to offer medical ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Gastrotomy Closure Considered Largest Hurdle in Adoption of Incisionless ... Translumenal Endoscopic Surgery (NOTES), SAN CLEMENTE, Calif., Dec. ... field of Incisionless Surgery, today announced that,its EndoSurgical Operating ... a gastrotomy (an incision in the stomach wall) during,a ...
... Protocol Assessment for Reviroc, AMSTERDAM, December 19 ... completed an End of Phase II meeting for ... Reviroc is under,development for elimination of cancer cells ... end-stage blood cancer patients. The FDA,agreed that the ...
... Inc., (Amex:,ADL), today announced that its subsidiary, Jade ... nutraceutical,diagnostic, consumer healthcare and personal care products, is ... Personal Care Center in Hangzhou,China. The state-of-the-art facility ... flagship JPGreen Health and Personal Care Center., ...
Cached Biology Technology:USGI Medical Demonstrates First System for Gastrotomy Closure in NOTES 2Kiadis Pharma Reports Successful End of Phase II Meeting With FDA for Reviroc 2AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2